A5101925996- Acute Myeloid Leukemia Research
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- S100 Proteins and Annexins
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Circular RNAs in diseases
- Biomarkers in Disease Mechanisms
- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- Protein Kinase Regulation and GTPase Signaling
- Genomics, phytochemicals, and oxidative stress
- Genetic and phenotypic traits in livestock
- Retinoids in leukemia and cellular processes
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- Acute Lymphoblastic Leukemia research
- Viral-associated cancers and disorders
- Peptidase Inhibition and Analysis
- Immune cells in cancer
Xinjiang Production and Construction Corps
2025
Third Affiliated Hospital of Southern Medical University
2024
Harbin Medical University
2021-2022
Third Affiliated Hospital of Harbin Medical University
2021-2022
University of Miami
2016-2021
Sylvester Comprehensive Cancer Center
2016-2021
Hunan Cancer Hospital
2020
Central South University
2020
Colorectal Surgical Associates
2010-2011
Abstract Protein arginine methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of residues in histones H3 and H4, marks that are generally associated with transcriptional repression. However, we found PRMT5 inhibition or depletion led to more genes being downregulated than upregulated, indicating can also act as a activator. Indeed, global level histone H3K27me3 increases deficient cells. Although does not directly affect PRC2 enzymatic activity, methylation by abrogates its...
S100A4 protein, a member of the S100 superfamily calcium-binding proteins, is frequently observed in various types human cancers, including colorectal cancer (CRC). Our previous investigations have demonstrated that overexpression associated with lymph node metastasis and poor prognosis CRC; however, its biological roles CRC remain unclear. In present study, we compared expression at mRNA protein levels six cell lines, found roughly coincided their invasiveness. Using RNA interference,...
AML1-ETO (AE) is a fusion transcription factor, generated by the t(8;21) translocation, that functions as leukemia promoting oncogene. Here, we demonstrate TATA-Box Binding Protein Associated Factor 1 (TAF1) associates with K43 acetylated AE and this association plays pivotal role in proliferation of AE-expressing acute myeloid (AML) cells. ChIP-sequencing indicates significant overlap TAF1 binding sites. Knockdown alters chromatin, affecting expression genes are activated or repressed AE....
Significance Double plant homeodomain finger 2 (DPF2) is a regulator of myeloid differentiation and implicated in range human cancers, including acute myelogenous leukemia. Recruitment DPF2 to chromatin has been shown alter the expression target genes inhibit differentiation. Here, we present crystal structure tandem domain comprehensive structure-guided biochemical vivo analyses. Combined, our data delineate determinants DPF2’s recruitment establish its regulatory role hematopoietic...
Circular RNAs (circRNAs) have been found to be important mediators of many biological processes in the growth and metastasis various cancers. However, potential roles most circRNAs progression bladder cancer remain unclear. In this research, we investigate role circKIF4A (hsa_circ_0007255) development cancer. Detected by qRT-PCR analysis, was significantly upregulated tissues cell lines. We conducted CCK-8, colony-formation, transwell mouse xenograft assays explore function Functionally,...
The resistance to occult mastitis in dairy cows is a multifaceted trait influenced by variety of genetic and environmental factors, posing significant challenges its prevention treatment. In this study, cohort 389 Holstein was selected for investigation. genes NOD2, CXCR1, SPP1 LF, which are implicated mastitis, were genotyped utilizing the efficient cost-effective Kompetitive Allele-Specific PCR (KASP) technology. Additionally, study analyzed association between various single nucleotide...
Myelodysplastic syndromes (MDS) are hematopoietic stem and progenitor cell (HSPC) malignancies characterized by ineffective hematopoiesis an increased risk of leukemia transformation. Epigenetic regulators recurrently mutated in MDS, directly implicating epigenetic dysregulation MDS pathogenesis. Here, we identified a tumor suppressor role the acetyltransferase p300 clinically relevant models driven mutations TET2, ASXL1, SRSF2. The loss enhanced proliferation self-renewal capacity...
To develop lymph node metastasis (LNM)-associated biomarkers for colorectal cancer (CRC) using quantitative proteome analysis.Differences in protein expression between primary CRC with LNM (LNM CRC) and without (non-LNM were assessed methyl esterification stable isotope labeling coupled 2D liquid chromatography followed by tandem mass spectrometry (2D-LC-MS/MS). The relationship to clinicopathological parameters prognosis of candidate was examined an independent sample set.Forty-three...
Abstract The activity of Rho family GTPase protein, RAC1, which plays important normal physiological functions, is dysregulated in multiple cancers. RAC1 expressed both estrogen receptor alpha (ER)-positive and ER-negative breast cancer (BC) cells. However, ER-positive BC more sensitive to inhibition. We have determined that reducing activity, using siRNA or EHT 1864 (a small molecule Rac inhibitor), leads rapid ER protein degradation. interacts with within the complex localizes chromatin...
The Dll4-Notch signaling pathway plays a crucial role in the regulation of angiogenesis and is promising therapeutic target for diseases associated with abnormal angiogenesis, such as cancer ophthalmic diseases. Here, we find that polyethylenimine (PEI), cationic polymer widely used nucleic acid transfection reagents, can Notch ligand Dll4. By immunostaining immunoblotting, demonstrate PEI significantly induces clearance cell-surface Dll4 facilitates its degradation through lysosomal...