A5103028625- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
- Noise Effects and Management
- Urban Green Space and Health
- Advanced Proteomics Techniques and Applications
- Analytical Chemistry and Sensors
- Adipose Tissue and Metabolism
- Health, Environment, Cognitive Aging
- Histone Deacetylase Inhibitors Research
- Retinoids in leukemia and cellular processes
- Genomics, phytochemicals, and oxidative stress
- Cardiovascular Health and Risk Factors
- Caveolin-1 and cellular processes
- Pesticide Exposure and Toxicity
- Ubiquitin and proteasome pathways
- Nuclear Physics and Applications
- Cancer-related molecular mechanisms research
- Optical Coherence Tomography Applications
- Computational Drug Discovery Methods
- Immune cells in cancer
- Plant biochemistry and biosynthesis
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Peking Union Medical College Hospital
2025
Zhejiang Chinese Medical University
2022-2024
Qiqihar Medical University
2020-2024
Wuhan University
2022-2024
Harbin Medical University
2020-2023
Xi’an Jiaotong-Liverpool University
2023
Third Affiliated Hospital of Harbin Medical University
2020-2023
Beihang University
2021
Cisplatin (DDP) resistance poses a significant challenge in the treatment of ovarian cancer. Studies have shown that combination certain polysaccharides derived from plants with DDP is an effective approach to overcoming drug some cancers. Angelica sinensis (Oliv.) Diels has been used for centuries China treat gynecological ailments. Numerous studies indicate polysaccharide (ASP), extract sinensis, can inhibit various forms However, impact ASP on cancer remains unexplored. Through both vitro...
Evidence regarding the combined effects of green space and air pollutants on hypertension remains limited complex. This study aims to investigate varying greenness under different pollution levels in China, using data from wave 2018 China Health Retirement Longitudinal Study (CHARLS) involving 17 468 adults (aged ≥ 45 years). As a result, prevalence rate was 42.04%. Logistic regression analyses revealed positive associations between concentrations at city level prevalent negative NDVI...
Introduction: Observational studies have linked loneliness or social isolation (SI) to ischemic heart disease (IHD), but results are inconsistent. Moreover, modifiable risk factors mediating the causal effects remain unclear. Hypothesis: and SI causally increase IHD risk, with metabolic behavioral acting as key mediators. Methods: Using genetic instruments derived from summary-level Genome-Wide Association Studies data of European ancestry, we performed a bidirectional two-sample Mendelian...
Convergent evidence links traditional brominated flame retardants (BFRs) exposure to weight gain, while the obesogenic potency of new BFRs (NBFRs) remain largely unknown. Aiding by luciferase-reporter gene assay, present study revealed only pentabromoethylbenzene (PBEB), an alternative for penta-BDEs, binds with retinoid X receptor α (RXRα) but not peroxisomeproliferator γ (PPARγ) among seven testing NBFRs. An apparent induction adipogenesis in 3T3-L1 cells was observed at nanomolar PBEB,...
Artemisia annua L. (A. annua), a Traditional Chinese Medicine (TCM) that has been utilized in China for centuries, is known its potential anticancer properties. However, the main components and mechanism of action A. on endometrial carcinoma have not reported. We used TCMSP database to identify active their corresponding gene targets. then obtained targets specific cancer from The Cancer Genome Atlas (TCGA) GeneCards databases. common three databases were selected, "component-target" network...
Lysine acetylation is a post-translational modification that regulates diversity of biological processes, including cancer development.Here, we performed the quantitative acetylproteomic analysis three primary cervical tissues and corresponding adjacent normal by using label-free proteomics approach.We identified total 928 lysine sites from 1547 proteins, in which 495 to 296 proteins were quantified. Further, 41 differentially expressed 30 obtained compared with (Fold change > 2 P < 0.05), 1...
Environmental chemical exposures have been associated with metabolic outcomes, and typically, their binding to nuclear hormone receptors is considered the molecular initiating event (MIE) for a number of outcomes. However, more studies are needed understand influence such on cell membrane-bound adiponectin (AdipoRs), which critical regulators.
Triphenyl phosphate (TPhP) is mostly residual in fat-rich foodstuff and ingestion the main route for adolescents' exposure. As a typical metabolic disruptor, however, sex-specific effect of TPhP-high fat diet (HFD) co-exposure adolescent remains unknown. This study revealed that HFD exacerbated systematic inflammation insulin insensitivity female mice at pubertal stage after exposure to 25 mg/kg TPhP or above. Notably, pattern sexual selective disruption caused by was irrespective examined...
Abstract Background Early extubation is a critical procedure for fast-track and enhanced recovery after surgery (ERAS) in cardiac adult patients. It might improve patients postoperative recovery. Many factors have been suggested anesthetic management improved, but early remains major challenge. This study aims to create nomogram prediction of early-extubation Method We reviewed medical records 442 consecutive undergoing elective surgeries from April 2023 July 2023. Factors were identified by...
Abstract Background Angelica sinensis (Oliv.) Diels has been used for centuries in Chinese traditional medicine to treat gynecological ailments. Numerous studies indicate that polysaccharide (ASP), an extract from sinensis, can inhibit various forms of cancer. Nevertheless, the therapeutic potential ASP treating ovarian cancer remains largely unexplored. Methods The study investigated cell proliferation and invasion, as well effects a combination DDP after tumor formation nude mice. Tumor...
Ethnopharmacological relevance In China, Angelica sinensis (Oliv.) Diels has been used to treat gynecological diseases for tens of thousands years, and many studies have shown that angelica polysaccharide (ASP), an extract sinensis, inhibitory effects on different types cancer. However, the therapeutic effect ASP ovarian cancer is rarely reported. Aim study order explore whether can cooperate with cisplatin (DDP) inhibit proliferation SKOV3/DDP cells which are cisplatin-resistant reverse...
Abstract Background: Cervical cancer remains a major cause of cancer-related death in women, especially developing countries. Previously, we identified that acetylation levels chloride intracellular channel 1 (CLIC1) at lysine 131 were increased cervical tissues by using the label-free proteomics approach. The aim this study was further to determine role CLIC1 expression and its cancer. Methods: implications on prognosis analyzed Gene Expression Profiling Interactive Analysis (GEPIA)...