A5100656598- Epigenetics and DNA Methylation
- Craniofacial Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Mosquito-borne diseases and control
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Temporomandibular Joint Disorders
- Cancer-related molecular mechanisms research
- Virology and Viral Diseases
- Cleft Lip and Palate Research
- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
- Circular RNAs in diseases
- dental development and anomalies
- Viral Infections and Vectors
- Microtubule and mitosis dynamics
- Developmental Biology and Gene Regulation
- Chemokine receptors and signaling
- Biomarkers in Disease Mechanisms
- Cerebral Venous Sinus Thrombosis
- Transgenic Plants and Applications
- Cancer-related gene regulation
- RNA Research and Splicing
- Head and Neck Cancer Studies
- Autophagy in Disease and Therapy
University of Southern California
2017-2025
Kunming Medical University
2020-2023
Yunnan University
2022
Second People's Hospital of Yunnan Province
2022
Wenzhou Medical University
2020
First Affiliated Hospital of Wenzhou Medical University
2020
University of Georgia
2015-2016
University of Colorado Anschutz Medical Campus
2012-2014
University of Colorado Denver
2012-2014
Howard Hughes Medical Institute
2012-2014
A dual role of the C9ORF72/SMCR8-containing complex in autophagy initiation and autophagic flux.
Zika virus (ZIKV) infection of pregnant women can result in fetal brain abnormalities. It has been established that ZIKV disrupts neural progenitor cells (NPCs) and leads to embryonic microcephaly. However, the fate other cell types developing their contributions ZIKV-associated abnormalities remain largely unknown. Using intracerebral inoculation mouse brains, we found postnatal growth restriction including In addition cycle arrest apoptosis NPCs, causes massive neuronal death axonal...
Neural progenitor cells (NPCs) have distinct proliferation capacities at different stages of brain development. Lin28 is an RNA-binding protein with two homologs in mice: Lin28a and Lin28b. Here we show that Lin28a/b are enriched early NPCs their expression declines during neural differentiation. single-knockout mice reduced NPC proliferation, enhanced cell cycle exit a smaller brain, whereas lacking both alleles one Lin28b allele display similar but more severe phenotypes. Ectopic results...
How self-renewal versus differentiation of neural progenitor cells is temporally controlled during early development remains ill-defined. We show that mouse Lin41 (mLin41) highly expressed in and its expression declines differentiation. Loss mLin41 function mice causes reduced proliferation premature embryonic cells. was recently implicated as the E3 ubiquitin ligase mediates degradation Argonaute 2 (AGO2), a key effector microRNA pathway. However, our mechanistic studies indicate not...
The Zika virus (ZIKV) has two lineages, Asian and African, their impact on developing brains not been compared. Dengue (DENV) is a close family member of ZIKV co-circulates with ZIKV. Here we performed intracerebral inoculation embryonic mouse dengue 2 (DENV2), found that DENV2 sufficient to cause smaller brain size due increased cell death in neural progenitor cells (NPCs) neurons. Compared the currently circulating lineage (MEX1-44), grows slower, causes less neuronal death, fails...
Temporomandibular joint (TMJ) osteoarthritis with pain is a highly prevalent disorder affecting patients' quality of life. A comprehensive understanding cell type diversity and its dynamics in painful TMJ (TMJOA) lacking. Here, we utilized an inflammatory TMJOA mouse model via intra-articular injection CFA. mice exhibited cartilage remodeling, bone loss, synovitis, increased (OA) score, orofacial pain, recapitulating hallmark symptoms patients. Single-cell transcriptomic profiling the was...
Neural progenitor cells (NPCs) undergo rapid proliferation during neurulation. This growth generates a high demand for mRNA translation in timing-dependent manner, but its underlying mechanism remains poorly understood. Lin28 is an RNA-binding protein with two paralogs, Lin28a and Lin28b, mammals. Mice Lin28b deletion exhibit no developmental defects, whereas we previously reported that led to microcephaly. Here found Lin28a/b double knockout (dKO) mice displayed neural tube defects (NTDs)...
Introduction: The side effects of conventional therapy for acute deep vein thrombosis (DVT) are severe, with inflammatory reactions playing a pivotal role. It is particularly important to explore new ways treatment by targeting factors. Methods: A targeted microbubble contrast agent was prepared using the biotin-avidin method. 40 DVT model rabbits were established and divided into four groups according different regimens. coagulation indexes, TNF-α, D-dimer content experimental animals...
Laryngeal squamous cell carcinoma (LSCC) is one of the most common laryngeal tumors, and its incidence increasing yearly; however, whether lymph node dissection should be performed during surgery remains unclear. We retrospectively analyzed clinical pathological data 246 cases LSCC developed a nomogram for prediction metastasis (LNM) LSCC. The predictive performance consistency model were evaluated using coefficient (C-index) calibration curve, respectively. Among LSCC, 52 had with...
Temporomandibular joint (TMJ) pain and osteoarthritis (OA) are common debilitating disorders that impair patients' quality of life. The mechanisms driving diseases-related poorly understood, current treatments fail to provide effective long-term therapeutic effects. Additionally, assessment in research, particularly orofacial pain, poses several challenges complicate studies both clinical basic science settings. Therefore, we have established an inflammatory TMJ mouse model via...
Disruption of global ribosome biogenesis selectively affects craniofacial tissues with unclear mechanisms. Craniosynostosis is a congenital disorder characterized by premature fusion cranial suture(s) loss suture mesenchymal stem cells (MSCs). Here we focused on ribosomopathy disease gene Snord118, which encodes small nucleolar RNA (snoRNA), to genetically disturb in MSCs using mouse and human induced pluripotent cell (iPSC) models. Snord118 depletion exhibited p53 activation, increased...
The Zika virus (ZIKV) is a flavivirus currently endemic in North, Central, and South America. It now established that the ZIKV can cause microcephaly additional brain abnormalities. However, mechanism underlying pathogenesis of developing remains unclear. Intracerebral surgical methods are frequently used neuroscience research to address questions about both normal abnormal development function. This protocol utilizes classical techniques describes allow one model ZIKV-associated human...
Abstract Heterozygous loss-of-function mutations of TCF12 and TWIST1 can each cause craniosynostosis neurodevelopmental delay in humans. Twist1-Tcf12 interaction plays an important role regulating suture development. Although the molecular cellular mechanisms underlying neurocognitive dysfunctions Twist1 +/- mice have been studied, less information on Tcf12 these defects is available. To investigate functional mechanism skull brain development, we analyzed shape Wnt1-Cre;Mesp1-Cre;Tcf12...
Background. This study investigated whether vascular endothelial necroptosis is involved in deep vein thrombosis (DVT) and how IL-17B facilitates signaling. Methods. The DVT mouse model was induced by ligation of the IVC. cross-sectional area thrombus increases occupied entire venous lumen at 48 h after ligation. Meanwhile, increased expression p-RIP3/RIP3 most pronounced ligation, p-MLKL/MLKL peaked 72 h. Results. Based on Illumina sequencing KEGG pathway analyses, activated RIP3/MLKL...
Venous thromboembolism (VTE) is the comorbidity of deep vein thrombosis (DVT) and pulmonary embolism (PE); it an urgent public health problem. The primary cause venous endothelial dysfunction caused by vascular injury inflammation or overexpressed procoagulant factors. Previous studies have shown that cell apoptosis involved in thrombosis, causing wall damage. pro-inflammatory cytokine interleukin-17 (Il-17A) induces promotes thrombosis. However, remains unclear whether other IL-17 family...