A5100774925- Proteoglycans and glycosaminoglycans research
- Alzheimer's disease research and treatments
- Probiotics and Fermented Foods
- Dermatology and Skin Diseases
- Lymphoma Diagnosis and Treatment
- Silkworms and Sericulture Research
- Chronic Lymphocytic Leukemia Research
- Insect and Arachnid Ecology and Behavior
- Escherichia coli research studies
- Wnt/β-catenin signaling in development and cancer
- Allergic Rhinitis and Sensitization
- Glycosylation and Glycoproteins Research
- Insect and Pesticide Research
- Carbohydrate Chemistry and Synthesis
- Machine Learning and Data Classification
- Legume Nitrogen Fixing Symbiosis
- Oral microbiology and periodontitis research
- Cutaneous lymphoproliferative disorders research
- Food Allergy and Anaphylaxis Research
- Essential Oils and Antimicrobial Activity
- Silk-based biomaterials and applications
- Barrier Structure and Function Studies
- Plant-Microbe Interactions and Immunity
- Lung Cancer Treatments and Mutations
- Animal Nutrition and Physiology
Hefei University of Technology
2023-2025
Zhejiang University
2017-2024
First Affiliated Hospital Zhejiang University
2020-2024
Shaanxi University of Science and Technology
2024
Nanjing University
2024
University of South Florida
2019-2023
USF Health Byrd Alzheimer's Institute
2022
Chinese Academy of Sciences
2017-2022
Kunming Institute of Zoology
2017-2022
Fujian Agriculture and Forestry University
2019-2021
The Zika virus (ZIKV) has two lineages, Asian and African, their impact on developing brains not been compared. Dengue (DENV) is a close family member of ZIKV co-circulates with ZIKV. Here we performed intracerebral inoculation embryonic mouse dengue 2 (DENV2), found that DENV2 sufficient to cause smaller brain size due increased cell death in neural progenitor cells (NPCs) neurons. Compared the currently circulating lineage (MEX1-44), grows slower, causes less neuronal death, fails...
Abstract Prion‐like transcellular spreading of tau in Alzheimer's Disease (AD) is mediated by binding to cell surface heparan sulfate (HS). However, the structural determinants for tau–HS interaction are not well understood. Microarray and SPR assays structurally defined HS oligosaccharides show that a rare 3‐ O ‐sulfation (3‐ ‐S) significantly enhances binding. In Hs3st1 −/− (HS ‐sulfotransferase‐1 knockout) cells, reduced ‐S levels diminished both internalization tau. culture, addition...
BackgroundFilaggrin, which is encoded by the filaggrin gene (FLG), an important component of skin's barrier to external environment, and genetic defects in FLG strongly associate with atopic dermatitis (AD). However, not all patients AD have mutations.ObjectiveWe hypothesized that these might possess other expression processing contributing disruption AD, therefore we present novel therapeutic targets for this disease.ResultsWe describe relationship between mechanistic target rapamycin...
This article documents the Qingdao Long-term Care Medical Insurance (LTCMI) program and analyzes its recipient demographics, costs of expansion potential drivers costs. About 10% program's clients received institutional care, while rest care at home or in other residential locations. More than 60% recipients were aged 80 years older. Analysis exit (mostly due to mortality) patterns from long-term system suggests that rates correlated with being older time joining, gender, types...
The present study examined dynamic interhemispheric structural and functional connectivity in mild traumatic brain injury (mTBI) patients with longitudinal observations from early subacute to chronic stages within 1 year of injury. Forty-two mTBI 42 matched healthy controls underwent clinical neuropsychological evaluations, diffusion tensor imaging, resting-state magnetic resonance imaging. All were initially evaluated 14 d post-injury (T-1) at 3 months (T-2) 6-12 (T-3) follow-ups. Separate...
Visible genetic markers are critical to gene function studies using genome editing technology in insects. However, there is no report about visible phenotypic Apis mellifera, which extremely influences the application of genomic honey bees. Here, we cloned and characterized Amyellow-y A. mellifera. Stage expression profiles showed that was highly expressed 2-, 4-day-old pupae, newly emerged bees, a high level detected leg, thorax, wing sting. To understand its functional role pigmentation,...
Apolipoprotein E (ApoE)'s ϵ4 alle is the most important genetic risk factor for late onset Alzheimer's Disease (AD). Cell-surface heparan sulfate (HS) a cofactor ApoE/LRP1 interaction and prion-like spread of tau pathology between cells. 3-O-sulfo (3-O-S) modification HS has been linked to AD through its with tau, enhanced levels 3-O-sulfated 3-O-sulfotransferases in brain. In this study, we characterized ApoE/HS interactions wildtype ApoE3, AD-linked ApoE4, AD-protective ApoE2...
Abstract Objective The purpose of this study was to assess the composition oral microbial flora adults with rampant caries in China provide guidance for treatment. Patients and methods Sixty human salivary supragingival plaque samples were collected. They characterized into four groups: patients Sjogren’s syndrome (RC-SS) or high-sugar diet (RC-HD), common dental (DC), healthy individuals (HP). 16S rRNA V3-V4 region bacterial DNA detected by Illumina sequencing. PCoA based on OTU Bray–Curtis...
Objective: HIV-1 infection is associated with alterations of several vascular endothelial functions including adhesion molecule expression, growth, and permeability. The bases these errors are not known, but might involve secretion the derived transcription factor `Tat-1'. This study investigated Tat-1 mediated barrier changes second message regulation this phenomenon. Methods: We exposed human umbilical vein cell monolayers to (0–150 ng/ml) for up 48 h measured resulting in monolayer also...
The type III secretion system (T3SS) is the main machinery for Pseudomonas savastanoi and other gram-negative bacteria to invade plant cells. HrpR HrpS form a hetero-hexamer, which activates expression of HrpL, induces all T3SS genes by binding 'hrp box' in promoters. However, individual molecular mechanism or has not been fully understood. Through chromatin immunoprecipitation coupled high-throughput DNA sequencing, we found that HrpR, HrpS, HrpL had four, 47, 31 targets on genome,...
Exploring whether and how mutation of silk protein contributes to subsequent re-allocation nitrogen, impacts on the timing gland degradation, is important understand biology. Rapid development wide application genome editing approach in silkworm provide us an opportunity address these issues. Using CRISPR/Cas9 system, we successfully performed Bmfib-H. The loss-of-function mutations caused naked pupa thin cocoon mutant phenotypes. Compared with wild type, posterior showed obviously degraded...
ABSTRACT Objective : To examine how cell‐substrate adhesion is regulated during barrier changes produced by exposure to inflammatory mediators. Methods Lung microvascular endothelial monolayers were treated with test agents ± blockers, and was measured transendothelial resistance; assessed surface area conservation after trypsin treatment of monolayers. Protein phosphorylation distribution assayed immunoblotting fluorescent microscopy, respectively. Results H 2 O , histamine, bradykinin,...
Exopolysaccharides produced during green olive fermentation reduce the attachment of ETEC K88 to IPEC-J2 cells, suggesting their potential in prevention or treatment diarrhoea.
Many plant bacterial pathogens including Pseudomonas species, utilize the type III secretion system (T3SS) to deliver effector proteins into cells. Genes encoding T3SS and its effectors are repressed in nutrient-rich media but rapidly induced after bacteria enter a or transferred nutrient-deficient media. To understand how genes regulated, we screened for P. savastanoi pv. phaseolicola (Psph) mutants displaying diminished induction of avrPto-luc, reporter genes, Arabidopsis. A mutant...