A5051068634- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Acupuncture Treatment Research Studies
- Venous Thromboembolism Diagnosis and Management
- Ferroptosis and cancer prognosis
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- RNA modifications and cancer
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Smoking Behavior and Cessation
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Cardiac Arrest and Resuscitation
- Optical Coherence Tomography Applications
- Flavonoids in Medical Research
- Myofascial pain diagnosis and treatment
- Adipose Tissue and Metabolism
- Ginseng Biological Effects and Applications
- Shoulder Injury and Treatment
- Lipid metabolism and disorders
- Genomics and Phylogenetic Studies
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
Inner Mongolia University
2023-2025
China Association of Acupuncture-Moxibustion
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
State Key Laboratory of Cardiovascular Disease
2021-2024
Fu Wai Hospital
2023-2024
Ruijin Hospital
2021-2024
Chinese University of Hong Kong
2024
Guangzhou University of Chinese Medicine
2024
Shanghai Jiao Tong University
2004-2022
Hefei Institutes of Physical Science
2022
Background: Bladder cancer (BCa) is a prevalent urologic malignancy that shows poor prognosis.Abnormal metabolism and its key genes play critical role in BCa progression.In this study, the played by PhosphoGlycerol Dehydrogenase (PHGDH), an important molecule of serine metabolism, was investigated with regard to regulation ferroptosis BCa.Methods: The tissues 90 patients were analyzed RNA-sequencing for differential pathways genes.Western blot, qPCR, IHC used determine PHGDH expression cell...
Importance Tongxinluo, a traditional Chinese medicine compound, has shown promise in vitro, animal, and small human studies for myocardial infarction, but not been rigorously evaluated large randomized clinical trials. Objective To investigate whether Tongxinluo could improve outcomes patients with ST-segment elevation infarction (STEMI). Design, Setting, Participants Randomized, double-blind, placebo-controlled trial was conducted among STEMI within 24 hours of symptom onset from 124...
Background Contrast‐induced acute kidney injury ( CI‐AKI ) is one of the most serious complications in patients who undergo percutaneous coronary intervention PCI ), especially those with syndrome. It has been shown that inflammation may play an important role pathophysiology . Hypothesis Inflammatory factors a predominant prediction emergency Methods Patients underwent from 2013 to 2015 were consecutively enrolled and divided into non– groups. Logistic analysis was used identify risk...
ABSTRACT Background Multiple epigenetic regulatory mechanisms are crucial in tumorigenesis and development. However, the synergistic relationship between N6‐methyladenosine (m6A) histone modifications regulating gene expression of gastric cancer (GC) requires further investigation. Results Here, based on microarray, RNA‐seq, survival analysis data, m6A methyltransferase METTL16 was identified as a potential tumorigenic factor GC. The silence suppresses malignant phenotype GC cells, NF‐κB...
Only a few randomized trials have analyzed the clinical outcomes of elderly ST-segment elevation myocardial infarction (STEMI) patients (≥ 75 years old). Therefore, best reperfusion strategy has not been well established. An observational study focused on was performed in this population.Based national registry STEMI patients, in-hospital with different strategies were compared. The primary endpoint defined as death. Secondary endpoints included recurrent infarction, ischemia driven...
Previous studies of contrast-induced acute kidney injury (CI-AKI) were mostly based on selective percutaneous coronary intervention (PCI) cases, and risk factors CI-AKI after emergency PCI are unclear. The aim this study was to explore the in a Chinese population undergoing PCI.A total 1061 consecutive patients during January 2013 June 2015 enrolled divided into non-CI-AKI group. Univariable multivariable analyses used identify patients. defined as an increase serum creatinine ≥25% or ≥0.5...
Abstract Background Multiple genetic and epigenetic regulatory mechanisms play a vital role in tumorigenesis development. Understanding the interplay between different modifications its contribution to transcriptional regulation cancer is essential for precision medicine. Here, we aimed investigate N6-methyladenosine (m6A) histone lung adenocarcinoma (LUAD). Results Based on data from public databases, including chromatin property (ATAC-seq, DNase-seq), methylated RNA immunoprecipitation...
Acute ST-segment elevation myocardial infarction (STEMI) remains a serious life-threatening event. Despite coronary revascularization, patients might still suffer from poor outcomes caused by no-reflow and ischemic/reperfusion injury. Tongxinluo (TXL), traditional Chinese medicine, has been preliminarily demonstrated to reduce We further hypothesize that TXL treatment is also effective in reducing clinical end points for the with STEMI. The CTS-AMI trial prospective, randomized,...
A Gram-positive, aerobic, neutrophilic and rod-shaped bacterium, strain Shh49T, was isolated from a deep-sea sediment sample collected the East Pacific polymetallic nodule region. The able to grow within temperature range of 4–35 °C tolerated up 7.5 % (w/v) NaCl. Strain Shh49T characterized chemotaxonomically by having MK-12 MK-13 as predominant isoprenoid quinones, anteiso-C15 : 0, iso-C15 iso-C16 0 anteiso-C17 major fatty acids ornithine cell-wall diamino acid. genomic DNA G+C content 66.8...
A Gram-negative, aerobic, motile, halophilic bacterium, designated strain BC7(T), was isolated from a salt mine in north-western China and subjected to polyphasic taxonomic characterization. The isolate able grow the presence of 0.5-20 % (w/v) NaCl at pH 6.0-9.0 4-48 degrees C; optimum growth observed with 3 7.0 30 C. Cells were long rods, 0.8-1.2 microm wide 4.0-6.0 long. major fatty acids C(18 : 1)omega7c, C(16 0) 0)omega7c. DNA G+C content 65.5 mol%. Phylogenetic analysis based on 16S...
Polymorphisms in platelet receptor genes may influence function. This study aimed to assess the impact of five polymorphisms encoding receptors on risk ischemic and bleeding events ST-elevation myocardial infarction (STEMI) patients after percutaneous coronary intervention (PCI). 503 consecutive Chinese with STEMI an uneventful PCI exposed standard dual antiplatelet therapy for 12 months were enrolled. receptors, GPIa (ITGA2, 807C > T, rs1126643), GPVI (GP6, 13254T C, rs1613662), PAR-1 (F2R,...
Background: To explore the immediate effects and mechanism of acupuncture on craving after tobacco cessation based fractional amplitude low-frequency fluctuation (fALFF). Methods: This was a functional magnetic resonance imaging (fMRI) study. Forty participants were recruited divided into smoking group non-smoking group, 20 cases in each one. The requested to quit 24 hours before fMRI scan. scan process – Between two scans, applied at Lieque (LU 7), Hegu (LI 4), Baihui (GV 20), Zusanli (ST...
This was a prospective multicenter observational study, aiming to explore the effects of acupuncture on smoking cessation in Hong Kong. From March 2010 August 2015, total 5202 smokers were recruited based inclusion criteria and treated with for 8 weeks. As result, 2940 subjects finished study drop-out rate 43.48%. The self-reported 7-day point abstinence 34.00% Week 18.40% 52. exhaled carbon monoxide level number cigarettes smoked per day reduced significantly after treatment. time relapse...
Abstract Background Multiple genetic and epigenetic regulatory mechanisms are crucial in the development tumorigenesis process. Transcriptional regulation often involves intricate relationships networks with post-transcriptional molecules, impacting spatial temporal expression of genes. However, synergistic relationship between transcription factors N6-methyladenosine (m6A) modification regulating gene expression, as well their influence on underlying occurrence progression non-small cell...