A5087731268- Plant Virus Research Studies
- MicroRNA in disease regulation
- Plant-Microbe Interactions and Immunity
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Clostridium difficile and Clostridium perfringens research
- Hepatitis B Virus Studies
- High Entropy Alloys Studies
- Sesquiterpenes and Asteraceae Studies
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- S100 Proteins and Annexins
- Plant Stress Responses and Tolerance
- CRISPR and Genetic Engineering
- Plant Disease Resistance and Genetics
- Plant Parasitism and Resistance
- Gut microbiota and health
- Plant Molecular Biology Research
- Hepatitis C virus research
- Polysaccharides and Plant Cell Walls
- Allelopathy and phytotoxic interactions
- Liver Disease Diagnosis and Treatment
- Proteins in Food Systems
- RNA Research and Splicing
- Medicinal Plants and Bioactive Compounds
Inner Mongolia University
2024
Sichuan Agricultural University
2021-2024
Zhengzhou University
2024
Advanced Technology & Materials (China)
2024
Heilongjiang University of Chinese Medicine
2023
Sutherland Hospital
2023
St George Hospital
2023
Royal Prince Alfred Hospital
2023
St. George Hospital
2023
Peking Union Medical College Hospital
2023
In the human brain, microRNAs (miRNAs) from microRNA-376 (miR-376) cluster undergo programmed “seed” sequence modifications by adenosine-to-inosine (A-to-I) editing. Emerging evidence suggests a link between impaired A-to-I editing and cancer, particularly in high-grade gliomas. We hypothesized that disruption of alters expression genes regulating glioma tumor phenotypes. By sequencing miR-376 cluster, we show overall miRNA frequencies were reduced Specifically gliomas, miR-376a* accumulated...
Calcium signaling is essential for environmental responses including immune responses. Here, we provide evidence that the evolutionarily conserved protein BONZAI1 (BON1) functions together with autoinhibited calcium ATPase10 (ACA10) and ACA8 to regulate signals in Arabidopsis. BON1 a plasma membrane localized negatively regulates expression of receptor genes positively stomatal closure. We found interacts autoinhibitory domains ACA10 ACA8, aca10 loss-of-function (LOF) mutants have an...
Viral infection affects the pattern of plant miRNA expression. It has been presumed that reduction miR171 and several other miRNAs influences viral symptoms in plants. We here experimentally demonstrate association osa-miR171b with rice stripe virus (RSV) rice. Inhibition caused stunting reduced chlorophyll content leaves similar to symptoms. Overexpression by an artificial extended vegetative growth enhanced accumulation leaves. Tillers were thicker, panicles longer more spikelets plants...
In plants, autophagy is involved in responses to viral infection. However, the role of host factors mediating suppress viruses poorly understood. A previously uncharacterized plant protein, NbP3IP, was shown interact with p3, an RNA-silencing suppressor protein encoded by Rice stripe virus (RSV), a negative-strand RNA virus. The potential roles NbP3IP RSV infection were examined. degraded p3 through pathway, thereby affecting silencing suppression activity p3. Transgenic overexpression...
Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is a promising therapeutic target for cancer therapy. In this work, we presented the structure-guided design of 5,6-fused bicyclic allosteric SHP2 inhibitors, leading to identification pyrazolopyrazine-based TK-642 as highly potent, selective, orally bioavailable inhibitor (SHP2
RNA silencing is an evolutionarily conserved antiviral mechanism, through which virus-derived small interfering RNAs (vsiRNAs) playing roles in host defence are produced virus-infected plant. Deep sequencing technology has revolutionized the study on interaction between virus and plant analysis of vsiRNAs profile. However, comparison vsiRNA profiles different tissues from a same been rarely reported. In this study, leaves fruits Lagenaria siceraria plants infected with Cucumber green mottle...
Ferredoxin 1 (FD1) accepts and distributes electrons in the electron transfer chain of plants. Its expression is universally downregulated by viruses its roles plant immunity have been brought into focus over past decade. However, mechanism which regulate FD1 remains to be defined. In a previous report, we found that Nicotiana benthamiana (NbFD1) was following infection with potato virus X (PVX) NbFD1 regulates callose deposition at plasmodesmata play role defense against PVX infection. We...
AGD2-LIKE DEFENCE RESPONSE PROTEIN 1 (ALD1) triggers plant defence against bacterial and fungal pathogens by regulating the salicylic acid (SA) pathway an unknown SA-independent pathway. We now show that Nicotiana benthamiana ALD1 is involved in a virus ethylene also participates ALD1-mediated resistance. NbALD1 was up-regulated plants infected with turnip mosaic (TuMV). Silencing of facilitated TuMV infection, while overexpression or exogenous application pipecolic (Pip), downstream product...
Studies have shown that microRNAs (miRNAs) mediate posttranscriptional regulation of target genes and participate in various physiological pathological processes, including peripheral nerve injury. However, it is hard to select key miRNAs with essential biological functions among a large number differentially expressed miRNAs. Previously, we collected injured sciatic stumps at multiple time points after crush injury, examined gene changes different stages (acute, sub-acute, post-acute),...
MicroRNAs (miRNAs) play essential roles in plant development. There is increasing evidence that changed expression of miRNAs virus-infected plants contributes to the development viral symptoms. Here, we analysed altered Nicotiana benthamiana response Potato virus X (PVX) by Illumina Solexa sequencing. One 21 significantly affected, nbe-miR166h-p5, was closely associated with Using Tobacco rattle virus-based miRNA suppression (VbMS) system, found nbe-miR166h-p5 caused leaves turn dark green...
Abstract Minerals are stored in the aleurone layer and embryo during maize seed development, but how they affect endosperm development activity is unclear. Here, we cloned gene underlying classic kernel mutant shrunken4 (sh4) found that it encodes YELLOW STRIPE-LIKE oligopeptide metal transporter ZmYSL2. sh4 kernels had a shrunken phenotype with developmental defects starchy cells. ZmYSL2 showed iron zinc Xenopus laevis oocytes. Analysis using specific antibody indicated predominately...
Abstract Background Multiple genetic and epigenetic regulatory mechanisms are crucial in the development tumorigenesis process. Transcriptional regulation often involves intricate relationships networks with post-transcriptional molecules, impacting spatial temporal expression of genes. However, synergistic relationship between transcription factors N6-methyladenosine (m6A) modification regulating gene expression, as well their influence on underlying occurrence progression non-small cell...
S-100β, which is capable of exerting neurotrophic effects on cultured neurones and promoting the survival motor in vivo, has recently been found distinct rat hindbrain. Here we report that as well being present satellite Schwann cells, also sensory ganglia (dorsal root ganglion, trigeminal, petrosal, jugular nodose ganglia) but absent from superior cervical ganglion. In ganglia, many were immunoreactive, while staining intensity varied among neurones. Neuronal S-100β appeared developing rats...
Abstract Motivations: Biclustering is a clustering method that simultaneously clusters both the domain and range of relation. A challenge in multiple sequence alignment (MSA) sequences often intended to reveal groups conserved functional subsequences. Simultaneously, grouping can impact alignment; precisely kind dual situation biclustering address. Results: We define representation MSA problem enabling application algorithms. develop computer program for local MSA, BlockMSA, combines with...
Abstract Activation of neuronal nicotinic acetylcholine receptors (nAChRs) modulates the induction long‐term potentiation (LTP): a possible cellular mechanism learning. To investigate effect nicotine on synaptic plasticity in chronically lead‐exposed rats, field excitatory postsynaptic potentials and paired‐pulse facilitation (PPF) were recorded CA1 area hippocampal slices from 23–30‐day‐old rats. The results showed following. (1) Nicotine (1 µ m ) facilitated LTP by weak tetanic stimulation...
The breakthrough in derivation of human-induced pluripotent stem cells (hiPSCs) provides an approach that may help overcome ethical and allergenic challenges posed numerous medical applications involving human cells, including neural stem/progenitor (NSCs). Considering the great potential NSCs targeted cancer gene therapy, we investigated this study tumor tropism hiPSC-derived attempted to enhance by manipulation biological activities proteins are involved regulating migration toward cells....