A5044375127- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- Viral gastroenteritis research and epidemiology
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- Radiation Therapy and Dosimetry
- Molecular Biology Techniques and Applications
- Animal Virus Infections Studies
- Inflammatory Myopathies and Dermatomyositis
- Circular RNAs in diseases
- Ovarian cancer diagnosis and treatment
- Inflammatory Biomarkers in Disease Prognosis
- Ethics in Clinical Research
- Economic and Financial Impacts of Cancer
- Hepatitis Viruses Studies and Epidemiology
- Biomedical Ethics and Regulation
China-Japan Friendship Hospital
2024-2025
Peking University
2025
Nanjing Medical University
2024
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Yebio Bioengineering (China)
2021-2023
Jilin Agricultural University
2021-2023
Hainan Medical University
2020-2023
Haukeland University Hospital
2023
Huazhong University of Science and Technology
2022
Abstract Cancer is a hyper-proliferative disease. Whether the proliferative state originates from cell-of-origin or emerges later remains difficult to resolve. By tracking de novo transformation normal hematopoietic progenitors expressing an acute myeloid leukemia (AML) oncogene MLL-AF9, we reveal that cell cycle rate heterogeneity among granulocyte–macrophage (GMPs) determines their probability of transformation. A fast intrinsic these provide permissiveness for transformation, with fastest...
Abstract Background Vitamin D deficiency is associated with a variety of chronic metabolic diseases. Limited evidence regarding vitamin exists within the Chinese population. The present study aims to examine association between serum concentrations and cardiometabolic risk factors in young middle-aged, urban population Methods cross-sectional relationships 25-hydroxyvitamin [25(OH)D] indices adiposity (e.g., body mass index, waist circumference, fasting plasma glucose, etc.) were evaluated...
Objective The coronavirus disease pandemic brought unknown challenges to patients with idiopathic inflammatory myopathy, who are often heavily immunosuppressed and have comorbidities. We aimed investigate the outcomes risk factors of in Chinese myopathy during Omicron wave. Methods This observational study included visited China-Japan Friendship Hospital. Data on baseline characteristics disease-related information were collected through medical records surveys, subsequently analysed....
Bovine viral diarrhea caused by bovine virus (BVDV) is an important disease in cattle, resulting significant economic losses to the cattle industry worldwide. In order develop effective vaccine against BVDV infection, we constructed a dendritic cell (DC)-targeting oral probiotic (pPG-E2-DCpep/LC W56) using Lactobacillus casei as antigen delivery carrier express glycoprotein E2 fused with DC-targeting peptide, and immunogenicity of orally administered was evaluated mice model. Our results...
MicroRNAs (miRNAs) are a family of non-coding RNAs approximately 21 nucleotides in length that play pivotal roles at the post-transcriptional level animals, plants and viruses. These molecules silence their target genes by degrading transcription or suppressing translation. Studies have shown miRNAs involved biological responses to variety biotic abiotic stresses. Identification these targets can aid understanding regulatory processes. Recently, prediction methods based on machine learning...
The impact of pregnancy on the clinical course acute hepatitis B (AHB) is still largely unclear, mainly because most studies have not included matched controls. This study was conducted to investigate features and outcome AHB in using Consecutive inpatients who were admitted Jinan Infectious Disease Hospital, Jinan, between January 2006 December 2010 evaluated followed. Demographic data, manifestations, results laboratory tests compared pregnant patients age sex non-pregnant at admission,...
Nuclear factor I (NFI) family is emerging found playing oncogenic or tumor-suppressive potential in cancers. However, the function and underlying mechanisms of NFIC, progression Lung Squamous Cell Carcinoma (LUSC) remain unclear. Therefore, this study aims to probe into NFIC development LUSC. In present study, we reported that was low expressed human LUSC tissues cell lines. inhibited proliferation promoted apoptosis vitro vivo. Moreover, also migration invasion. Furthermore, there were...
To date, anticancer immunotherapy has presented some clinical benefits to most of advanced mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) colorectal cancer (CRC) patients. In addition MSI status, we aimed reveal the potential predictive value adenomatous polyposis coli (APC) gene mutations in CRC A total 238 Chinese patients was retrospectively identified and analyzed for features alternations APC-mutant type (MT) APC-wild-type (WT) groups. Clinical responses were...
Purpose Immune checkpoint blockade has led to a significant improvement of patient survival in metastatic colorectal cancer (CRC) with DNA mismatch repair-deficiency (dMMR)/microsatellite instability-high (MSI-H). However, not all these patients are sensitive monoimmunotherapy. We firstly presented case series advanced dMMR/MSI-H CRCs treating PD-1 inhibitor-based chemoradioimmunotherapy (CRIT). Methods and Materials assessed the short-term efficacy safety CRIT CRCs, also did next-generation...
Although PD-L1 expression is a crucial predictive biomarker for immunotherapy, it can be influenced by many factors.A total of 248 Chinese patients with lung adenocarcinoma was retrospectively identified. Data clinical features, gene alternations, signaling pathways and immune signatures analyzed among negative group (TPS < 1%, n = 124), intermediate (1% ≤ TPS 50%, 93), high ≥ 38). Clinical outcomes different groups were also evaluated from public database.Firstly, tumor mutation burden...
Radiation-induced lung injury is a well-described complication of nuclear accidents, marrow-transplant pretreatment and thoracic radiotherapy. The mechanism complex no special therapy for it available at present. To study radiation pulmonary following heavy ion radiotherapy tumors, Kunming mice were randomly divided into 4 groups: normal control 2, 6 Gy irradiation groups which underwent whole-body exposure to 235 MeV/u (12)C(6+) administered the Heavy Ion Research Facility in Lanzhou...
Metastatic gallbladder carcinoma (GBC) is one of the most aggressive malignancies. As GBC usually diagnosed with distant metastases, only a few patients can receive R0 resection and relapse rate remains high. Programmed cell death protein 1 (PD-1) blockade therapy has provided encouraging long-term outcomes in subset many cancers. However, data on efficacy PD-1 are very limited.We herein reported stage IVB patient localized primary tumor lymph node metastasis. Except for unresectable...
The role of prodromal fever in the clinical course acute hepatitis B virus (HBV) infection is still largely unclear. This study was conducted to investigate factors associated with and its development liver failure (ALF) patients (AHB).Inpatients AHB diagnosed between January 2006 December 2010 were evaluated followed. Clinical manifestations, results laboratory tests, outcomes compared without fever. diagnosis based on discrete onset symptoms, jaundice, abnormal function detection...
Objectives: Extracranial carotid artery (ECCA) atherosclerosis is well known to be associated with cardiovascular diseases. This study aims investigate the difference of ECCA between patients xanthelasma and control subjects in normolipidaemia. Methods: Carotid (CA) 41 (8 males 33 females) normolipidaemia, defined as levels cholesterol below 6.21 mmol/l triglyceride 2.26 mmol/l, recruited from Department Dermatology was compared that 85 age- gender-matched subjects. The extent severity CA...
Immunotherapy alone or chemo-immunotherapy has recently been recommended for treating advanced lung carcinoma in patients without driver mutations. However, the efficacy of immunotherapy and molecular mechanism large-cell cancer (LCLC) remains unclear. Here, we reported a rare case multiple fulminant postoperative body mouth metastases LCLC with combination immunotherapy. Initially, patient was diagnosed as early stage underwent radical resection right lower lobe. Just one month later,...
Patau syndrome is a rare congenital malformation due to the presence of an extra chromosome 13. In this paper, we report generation induced pluripotent stem cell line from fibroblasts isolated chorionic villi early spontaneously aborted foetus with syndrome. The villus retains original trisomy 13 karyotype, expresses pluripotency markers and induces teratoma formation in NOD-SCID mice. This model should serve as tool study