A5100374224- Lung Cancer Research Studies
- Cervical Cancer and HPV Research
- Lung Cancer Treatments and Mutations
- Helicobacter pylori-related gastroenterology studies
- Antifungal resistance and susceptibility
- Animal Disease Management and Epidemiology
- Head and Neck Cancer Studies
- Parasitic Diseases Research and Treatment
- Gut microbiota and health
- HER2/EGFR in Cancer Research
- Virology and Viral Diseases
- Viral Infections and Vectors
- Animal Nutrition and Physiology
- Viral gastroenteritis research and epidemiology
- Cancer-related molecular mechanisms research
- Respiratory viral infections research
- Essential Oils and Antimicrobial Activity
- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Animal Virus Infections Studies
- Cytokine Signaling Pathways and Interactions
- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Infectious Disease Case Reports and Treatments
- Innovative Educational Techniques
Jilin Agricultural University
2022-2024
Affiliated Hospital of Guizhou Medical University
2023
Guiyang Medical University
2023
Chongqing University
2023
West China Hospital of Sichuan University
2023
Chongqing Medical University
2019-2023
First Affiliated Hospital of Nanchang University
2022-2023
Nanchang University
2022-2023
University of Rochester Medical Center
2023
Eastman Chemical Company (United States)
2023
Abstract Background The gut microbiota is a critical factor in the regulation of host health, but relationship between differential resistance hosts to pathogens and interaction microbes not yet clear. Herein, we investigated potential correlation piglets their disease using single-cell transcriptomics, 16S amplicon sequencing, metagenomics, untargeted metabolomics. Results Porcine epidemic diarrhea virus (PEDV) infection leads significant changes piglets. Notably, Landrace pigs lose quickly...
Backgrounds Gut microbiota plays a critical role in the onset and development of depression, but underlying molecular mechanisms are unclear. This study was conducted to explore relationships between gut host’s metabolism depression. Methods Chronic social defeat stress (CSDS) model depression established using C57BL/6 male mice. Fecal samples were collected from CSDS group control measure microbial metabolites. Meanwhile, tryptophan metabolism-related metabolites hippocampus also analyzed....
ABSTRACT Canine distemper virus (CDV) poses a severe threat to both domesticated and wild animals, including multiple carnivores. With the continued expansion of its host range, there is an urgent need for development safer more effective vaccine. In this study, we developed subunit vaccines based on bacterium-like particle (BLP) delivery platform containing BLPs-F BLPs-H, which display CDV F H glycoprotein antigens, respectively, using antigen-protein anchor fusions produced by recombinant...
The Systemic Inflammatory Response Index (SIRI) is a promising inflammatory marker; however, the relationship between SIRI and latent tuberculosis infection (LTBI), as well its association with mortality rates, remains unclear. present study aimed to explore associations of LTBI all-cause mortality. We conducted prospective cohort using data from National Health Nutrition Examination Survey (NHANES) cycles 2011 2012. explored prevalence Multiple logistic regression models. used Multivariate...
Placental abruption is a serious obstetric complication, which poses threat to the life of mother and child. A high degree clinical judgment operational skills are required by medical staff in handling such cases. However, traditional teaching methods often cannot provide enough response real experience, cases placental practice relatively rare, causes students lacking ability deal with. With development virtual simulation technology, construction experimental platform for has become an...
The oral mucosal vaccine has great potential in preventing a series of diseases caused by porcine circovirus type 2 ( PCV2 ) infection. This study constructed recombinant Bacillus subtilis RB with Capsid protein Cap on its spore surface and cotB as fusion partner. immune properties the strain were evaluated mouse model. IgA intestinal contents IgG serum detected enzyme-linked immunosorbent assay (ELISA). results demonstrated that spores could activate strong specific humoral responses. In...
Objective The reports of the recreational use nitrous oxide (N 2 O) and its related neuropathy are increasing. However, it is unclear whether specific clinical characteristics associated with overall neurological impairments among these individuals. Methods We retrospectively included 20 hospitalized patients N O-related complaints between January 2016 March 2021 at West China Hospital Sichuan University. Detailed demographic, features, lab tests, imaging data were collected. A functional...
Rhodococcus equi is a conditionally pathogenic bacterium widely distributed in soil, water, and marine environments, which can cause respiratory infections, pleurisy, blood even bone marrow infections immunocompromised people, particularly patients with acquired immunodeficiency syndrome (AIDS). This case report describes patient initially suspicion of tuberculosis (TB) as an outpatient TB clinic. However, laboratory findings identified R. his sputum sample based on positive acid-fast stain,...
Abstract Background Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (mHS) deficiency is an autosomal recessive inborn error of metabolism, which will give rise to failure ketogenesis in liver during illness or fasting. It a very rare disease with only few patients reported worldwide, most had good prognosis after proper therapies. Case presentation We report 9-month-old boy mHS presenting unusually severe and persistent acidosis diarrhea reduced oral food intake. The metabolic...
Abstract Background: Although existing mycological tests (bronchoalveolar lavage [BAL] galactomannan [GM], serum GM, (1,3)-β-D-glucan [BDG], and fungal culture) are widely used for diagnosing invasive pulmonary aspergillosis (IPA) in non-hematological patients with respiratory diseases, their clinical utility this large population is actually unclear. We aimed to resolve uncertainty by evaluating the diagnostic accuracy of explore efficacy novel sputum-based Aspergillus assays. Methods:...
The carriage of Candida albicans in children's oral cavities is associated with a higher risk for early childhood caries, so controlling this fungus life essential preventing caries. In prospective cohort 41 mothers and their children from 0-2 years age, study addressed 4 main objectives: 1) Evaluate vitro the antifungal agent susceptibility isolates mother-child cohort, 2) Compare between children; 3) Assess longitudinal changes collected years; 4) Detect mutations C. resistance...
This trial evaluated how dietary-accommodated pomelo peel powder (PPP) affected average daily feed intake (ADFI) and gain (ADG), diarrhea, antioxidation, colonic microbial in weaned piglets. Thirty piglets at 28 d were divided into three groups: a basal diet (CON); CON containing 75 mg/kg chlortetracycline (CTC); 8 g/kg (PPP). had period of days. Piglets supplemented with PPP higher ADFI ADG than CTC (p < 0.05). The diarrhea rate was lower the 3rd 4th weeks Serum superoxide dismutase...
Listeria monocytogenes, is a Gram-positive facultative intracellular bacterium without spores. It can cause invasive diseases such as septicemia, meningitis, and encephalitis, has high mortality rate. This report on recent case of neurolisteriosis isolated from cerebrospinal fluid sample patient with diabetes chronic heart failure in our hospital. The initially received the combined treatment cephalosporin meropenem (both 1.0 g every 8 hours). We identified pathogenic organism L....
Parvimonas micra is a type of Gram-positive anaerobic cocci widely distributed in the oral cavity, gastrointestinal tract, respiratory and female reproductive system mucosa. It conditional pathogen that can cause infections human wounds, other areas as well sepsis. In this case report, patient's immune was compromised by various underlying diseases pulmonary infection, which led to entry P. infection into bloodstream. slow-growing organism (When bloodstream occurs, flagging an bottle blood...
Porcine rotavirus (PoRV) poses a threat to the development of animal husbandry and human health, leading substantial economic losses. The VP6 protein, most abundant component virus particles, is also virus's core structural protein. Initially, we developed an antibiotic-resistance-free, environmentally friendly expression vector, asd-araC-PBAD-alr (AAPA), constructed recombinant Lactobacillus plantarum (L. plantarum) strains induced by arabinose express VP6-pFc fusion proteins. Subsequently,...
Abstract The objective of this research was to evaluate and compare the pharmacokinetic profiles safety lisinopril/hydrochlorothiazide (10 mg/12.5 mg) tablets in test reference formulations administered participants both fasting postprandial states bioequivalence 2 products healthy Chinese volunteers. This study employed a single‐center, randomized, open‐label, single‐dose dosing trial involving cumulative 96 adult (60 group 36 group). Each comprised sequence sets, 2‐week washout period...