A5100758185- Marine Bivalve and Aquaculture Studies
- Aquaculture Nutrition and Growth
- Reproductive biology and impacts on aquatic species
- Sperm and Testicular Function
- Ocean Acidification Effects and Responses
- Optical Network Technologies
- Marine Biology and Environmental Chemistry
- SARS-CoV-2 and COVID-19 Research
- Reproductive Biology and Fertility
- Iron oxide chemistry and applications
- Advanced Photonic Communication Systems
- Marine and fisheries research
- Physiological and biochemical adaptations
- Aquaculture disease management and microbiota
- Cholesterol and Lipid Metabolism
- Cephalopods and Marine Biology
- biodegradable polymer synthesis and properties
- Bone health and osteoporosis research
- Marine Biology and Ecology Research
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- Photonic and Optical Devices
- Hip and Femur Fractures
- Parasite Biology and Host Interactions
- Drug Transport and Resistance Mechanisms
Ji Hua Laboratory
2023-2025
Nankai University
2024-2025
Beijing Academy of Science and Technology
2024-2025
Tsinghua University
2025
Sun Yat-sen University
2023-2024
Peking University
2017-2024
Army Medical University
2019-2024
University of Electronic Science and Technology of China
2014-2024
South Australian Research and Development Institute
2015-2024
Jilin Agricultural University
2023-2024
SARS-CoV-2 is responsible for the current COVID-19 pandemic. On basis of our analysis hepatitis C virus and coronavirus replication, molecular structures activities viral inhibitors, we previously demonstrated that three nucleotide analogues (the triphosphates Sofosbuvir, Alovudine, AZT) inhibit SARS-CoV RNA-dependent RNA polymerase (RdRp). We also a library additional terminate synthesis catalyzed by RdRp, well-established drug target COVID-19. Here, used extension experiments to...
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by extracellular senile plaques and intracellular neurofibrillary tangles in the brain. Amyloid-β peptides (Aβ) are considered to play critical role onset progression of AD. Apigenin (4',5,7-trihydroxyflavone) pharmacologically active agent. Even though some evidence suggests that it has potential neuroprotective effects, no preexisting study reported any therapeutic effects apigenin AD models. In present study, we...
Natural occurring ferrihydrite (Fh) nanoparticles have varying degrees of crystallinity, but how Fh crystallinity affects its transformation behavior remains elusive. Here, we investigated the Fe(II)-catalyzed with different (i.e., Fh-2h, Fh-12h, and Fh-85C). X-ray diffraction patterns Fh-85C exhibited two, five, six peaks, respectively, indicating order crystallinity: Fh-2h < Fh-12h Fh-85C. lower has a higher redox potential, corresponding to faster Fe(II)-Fh interfacial electron transfer...
Prognostic factors aid in the stratification and treatment of cancer. This study evaluated prognostic importance tumor infiltrating immune cell patients with oral squamous carcinoma.Profiles cells clinicopathological data were available for 78 OSCC a median follow-up 48 months. The intensity CD8, CD4, T-bet, CD68 CD57 positive assessed by immunohistochemistry. Chi-square test was used to compare markers expression parameters. Univariate multivariate COX proportional hazard models assess...
Biogeographic distributions are driven by cumulative effects of smaller scale processes. Thus, vulnerability animals to thermal stress is the result physiological sensitivities body temperature ( T b ), microclimatic conditions, and behavioural thermoregulation. To understand interactions among these variables, we analysed tolerances three species intertidal snails from different latitudes along Chinese coast, estimated potential in microhabitats at each site. We then empirically determined...
Ferrihydrite (Fh) is generally associated with dissolved organic matter (DOM) in natural environments due to a strong sorption affinity at circumneutral pH and its high specific surface area. In suboxic conditions, aqueous Fe(II) (Fe(II)aq) can catalyze transformation of Fh into more stable crystalline Fe(III) phases, but how DOM influences the kinetics pathway still unclear. Using citrate as surrogate, we have examined 1 mM Fe(II)aq 0-60 μM 7.2. We focus on quantifying time-dependent...
Abstract SARS‐CoV‐2, a member of the coronavirus family, has caused global public health emergency. Based on our analysis hepatitis C virus and replication, molecular structures activities viral inhibitors, we previously reasoned that FDA‐approved drug EPCLUSA (Sofosbuvir/Velpatasvir) should inhibit coronaviruses, including SARS‐CoV‐2. Here, using model polymerase extension experiments, demonstrate active triphosphate form Sofosbuvir is incorporated by low‐fidelity polymerases SARS‐CoV...
Abstract SARS-CoV-2 is responsible for COVID-19, resulting in the largest pandemic over a hundred years. After examining molecular structures and activities of hepatitis C viral inhibitors comparing virus coronavirus replication, we previously postulated that FDA-approved drug EPCLUSA (Sofosbuvir/Velpatasvir) might inhibit SARS-CoV-2. We subsequently demonstrated Sofosbuvir triphosphate incorporated by relatively low fidelity SARS-CoV RNA-dependent RNA polymerases (RdRps), serving as an...
Transformation of metastable Fe(III) oxyhydroxides is a prominent process in natural environments and can be significantly accelerated by the coexisting aqueous Fe(II) (Fe(II)aq). Recent evidence points to solution mass transfer labile (Fe(III)labile) as primary intermediate species general importance. However, mechanistic aspect that remains unclear dependence phase outcomes on identity oxyhydroxide precursor. Here, we compared coupled evolution species, solid phases, Fe(III)labile...
African swine fever (ASF) is a devastating infectious disease of pigs caused by the virus (ASFV), which poses great danger to global pig industry. Many viral proteins can suppress with interferon signaling evade host's innate immune responses. Therefore, development an effective vaccine against ASFV has been dampened. Recent studies have suggested that L83L gene may be integrated into host genome, weakening system, but underlying mechanism unknown. Our study found negatively regulates...
Hepatocellular carcinoma (HCC) is one of the most common cancers, with high mortality. Chemotherapy main treatment options for HCC. However, toxicity and poor specificity chemotherapeutic drugs have limited their clinical application. In this study, dual-ligand liposomes modified glycyrrhetinic acid (GA) cyclic arginine–glycine–aspartic (cRGD) (GA/cRGD-LP) were designed to target GA receptor αvβ3 integrin, respectively. The aim was develop a highly selective targeted drug delivery system...
Abstract Poly(ethylene terephthalate) (PET), extensively employed in bottles, film, and fiber manufacture, has generated persistent environmental contamination due to its non‐degradable nature. The resolution of this issue requires the conversion waste PET into valuable products, often achieved through depolymerization monomers. However, laborious purification procedures involved extraction monomers pose challenges constraints on complete utilization PET. Herein, a strategy is demonstrated...
Microdroplet chemistry has attracted much attention owing to its ability accelerate otherwise slow reactions and trigger thermodynamically forbidden reactions. The cause of this unique behavior is the intrinsic properties droplets, such as spontaneously generated electric field on droplet surface. However, some have argued that generation methods provided energy reactions, different interfaces droplets contact also played important roles; therefore, it activation or environment, not...
Mass mortality is often observed in cultured oysters during the period following spawning summer season. To examine underlying causes leading to this phenomenon, thermotolerance of Pacific oyster Crassostrea gigas was assessed using pre- and postspawning that were sequentially treated with sublethal (37 degrees C) lethal heat shocks (44 C). The effects examined on a range immune metabolic parameters addition rate. A preventative 37 C significantly reduced after exposure second shock 44 C,...
Abstract SARS-CoV-2, a member of the coronavirus family, is responsible for current COVID-19 pandemic. Based on our analysis hepatitis C virus and replication, molecular structures activities viral inhibitors, we previously demonstrated that three nucleotide analogues inhibit SARS-CoV RNA-dependent RNA polymerase (RdRp). Here, using extension experiments, have active triphosphate form Sofosbuvir (a key component FDA approved drug EPCLUSA), incorporated by SARS-CoV-2 RdRp, blocks further...
ABSTRACT The periwinkle snail Echinolittorina malaccana, for which the upper lethal temperature is near 55°C, one of most heat-tolerant eukaryotes known. We conducted a multi-level investigation – including cardiac physiology, enzyme activity, and targeted untargeted metabolomic analyses that elucidated spectrum adaptations to extreme heat in this organism. All systems examined showed intensity-dependent responses. Under moderate stress (37–45°C), depressed activity entered state metabolic...
Pacific oysters (Crassostrea gigas) and Mediterranean mussels (Mytilus galloprovincialis) are commercially important marine bivalves that frequently coexist have overlapping feeding ecologies. Like other invertebrates, their gut microbiota is thought to play an role in supporting health nutrition. Yet, little known regarding the of host environment driving these communities. Here, bacterial assemblages were surveyed from seawater aspirates farmed C. gigas co-occurring wild M....
Microdroplet chemistry is now well-known to be able remarkably accelerate otherwise slow reactions and trigger impossible reactions. The uniqueness of the microdroplet attributable either air–water interface or solid–liquid interface, depending on medium that in contact with. To date, importance might have been confirmed, but contribution from seems elusive due lack method for generating contactless microdroplets. In this study, we used a droplet atomization with acoustic levitation. Upon...