A5078446896- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Advanced Nanomaterials in Catalysis
- Virology and Viral Diseases
- Advanced biosensing and bioanalysis techniques
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- Rabies epidemiology and control
- Pharmaceutical and Antibiotic Environmental Impacts
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Extracellular vesicles in disease
- Bone Tissue Engineering Materials
- Bacteriophages and microbial interactions
- Mosquito-borne diseases and control
- Biosensors and Analytical Detection
- Nanoparticle-Based Drug Delivery
- Microbial infections and disease research
- Respiratory viral infections research
- CAR-T cell therapy research
- Click Chemistry and Applications
- Influenza Virus Research Studies
- Carbon and Quantum Dots Applications
Southern Medical University
2022-2025
Nanfang Hospital
2022-2025
Chinese Academy of Agricultural Sciences
2021-2024
Yangzhou University
2024
Jilin Agricultural University
2024
Jilin University
2022-2023
Jilin Academy of Agricultural Sciences
2022
Abstract Intrinsic or acquired radioresistance remained an important challenge in the successful management of cancer. Herein, a novel “smart” multifunctional copper‐based nanocomposite (RCL@Pd@CuZ) to improve radiotherapy (RT) sensitivity is designed and developed. In this nanoplatform, DSPE‐PEG‐RGD modified on liposome surface enhanced tumor targeting permeability; capsaicin inserted into phospholipid bilayer improved hypoxic conditions microenvironment (TME) by inhibiting mitochondrial...
ABSTRACT Canine distemper virus (CDV) poses a severe threat to both domesticated and wild animals, including multiple carnivores. With the continued expansion of its host range, there is an urgent need for development safer more effective vaccine. In this study, we developed subunit vaccines based on bacterium-like particle (BLP) delivery platform containing BLPs-F BLPs-H, which display CDV F H glycoprotein antigens, respectively, using antigen-protein anchor fusions produced by recombinant...
Abstract Tumor recurrence and wound infection present significant challenges to patient recovery following surgery, underscoring the need for effective therapeutic strategies improve prognosis by mitigating these complications. This study introduces novel synthesis methods honeycomb‐like CuMnOx nanozymes CuO 2 nanoflowers with multienzymatic activity pH‐responsive properties. The enzymatic activities of can be regulated pH changes in tumor or microenvironments, while overcome limitation...
The coronavirus disease 2019 pandemic has caused more than 532 million infections and 6.3 deaths to date. reactive neutralizing fully human antibodies of severe acute respiratory syndrome 2 (SARS-CoV-2) are effective detection tools therapeutic measures. During SARS-CoV-2 infection, a large number will be produced. Most isolated from frequently encoded by convergent heavy-chain variable genes. However, viruses can mutate rapidly during replication the resistant variants easily survive evade...
Rabies is a fatal neurological zoonotic disease caused by the rabies virus (RABV), and approved post-exposure prophylaxis (PEP) procedure remains unavailable in areas with inadequate medical systems. Although strategies have been proposed for PEP postinfection treatment (PIT), because of complexity procedures limited curative outcome, developing an effective strategy holy grail research. Herein, facile approach involving photothermal therapy (PTT) photothermally triggered immunological...
The emergence of SARS-CoV-2 variants stresses the continued need for broad-spectrum therapeutic antibodies. Several monoclonal antibodies or cocktails have been introduced clinical use. However, unremitting emerging showed reduced neutralizing efficacy by vaccine induced polyclonal In our study, and F(ab’) 2 fragments with strong affinity produced after equine immunization RBD proteins affinity. Notably, specific IgG broad high activity against parental virus, all concern (VOCs), including...
Therapeutic antibodies-F(ab')2 obtained from hyperimmune equine plasma could treat emerging infectious diseases rapidly because of their high neutralization activity and output. However, the small-sized F(ab')2 is eliminated by blood circulation. This study explored PEGylation strategies to maximize half-life anti-SARS-CoV-2 specific F(ab')2. Equine were combined with 10 KDa MAL-PEG-MAL in optimum conditions. Specifically, there two strategies: Fab-PEG Fab-PEG-Fab, bind a PEG or PEG,...
To study antimicrobial resistance and virulence genes of Klebsiella pneumoniae Raoultella strains isolated from captive giant pandas. Non-duplicate fecal samples were collected 128 pandas during 2017–2019. All microbial tested for drug susceptibility using BD verification panels. Four extended-spectrum β-lactamase genes, nine six capsular serotype detected PCR. 42 K . different Antibiotic rates 1.9%–23.5%, except ampicillin, 7.8% the isolates multidrug-resistant to 7–10 antibiotic classes....
Rabies, caused by the Rabies virus (RABV), is a highly fatal zoonotic disease. Existing rabies vaccines have demonstrated good immune efficacy, but complexity of immunization procedures and high cost has impeded elimination RABV, particularly in post-COVID-19 era. There pressing need for safer more effective that streamline vaccination protocols reduce expense. To meet this need, we developed potential vaccine candidate called ALVAC-RABV-VLP, utilizing CRISPR/Cas9 gene editing technology....
Bladder cancer is a common malignancy of the urinary system and development noninvasive therapeutic methods imperative to avoid radical cystectomy, which results in poor quality life for patients.
SARS-CoV-2 is a novel coronavirus that has caused global pandemic. To date, 504,907,616 people have been infected and developed disease 2019 (COVID-19). A rapid simple diagnostic method needed to control this In study, visual nucleic acid detection combining reverse transcription loop-mediated isothermal amplification vertical flow visualization strip (RT-LAMP-VF) was successfully established could detect 20 copies/μl of RNA transcript within 50 min at 61°C. This assay had no...
The emergence of Zika virus (ZIKV) infection, which is unexpectedly associated with congenital defects, has prompted the development safe and effective vaccines. gram-positive enhancer matrix-protein anchor (GEM-PA) display system emerged as a versatile highly platform for delivering target proteins In this article, we developed bacterium-like particle vaccine ZI-△-PA-GEM based on GEM-PA system. fusion protein ZI-△-PA, contains prM-E-△ ZIKV (with stem-transmembrane region deletion) PA3, was...
Background: Vaccines provide the most ideal protection against COVID-19, but variants of concern are highly transmissible and less sensitive to vaccine-elicited antibodies. We aimed determine T2D patients whether could mount an equal immune response COVID-19 vaccine compared with healthy individuals.Methods: measured antibody levels in serum samples from a cohort 100 participants after 2 doses inactivated virus using serological tests neutralisation assays, mechanistic insights into dampened...
In this study, we report the complete genome sequence of a multidrug-resistant Escherichia coli strain recovered from fecal sample captive giant panda in China. Antimicrobial susceptibility testing was performed. Genomic DNA E. DC71 sequenced using Nanopore PromethION sequencer instrument (Oxford Technologies, UK) and MGI High-throughput Sequencing MGISEQ-2000 platforms. The clean reads were de novo assembled SPAdes v3.11. annotated analyzed multilocus typing, serotyping, plasmid replicons,...
Abstract Background: In 2011, a new influenza virus, named Influenza D Virus (IDV), was isolated from pigs, and then cattle, presenting influenza-like symptoms. IDV is one of the causative agents Bovine Respiratory Disease (BRD), which causes high morbidity mortality in feedlot cattle worldwide. To date, molecular mechanisms pathogenicity are unknown. Recent outbreaks along with serological genetic evidence infection humans, have raised concerns regarding zoonotic potential this virus. virus...