A5100385433- Alzheimer's disease research and treatments
- Advanced Nanomaterials in Catalysis
- Autophagy in Disease and Therapy
- Gut microbiota and health
- Phytochemicals and Antioxidant Activities
- Neuroinflammation and Neurodegeneration Mechanisms
- Amoebic Infections and Treatments
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Heme Oxygenase-1 and Carbon Monoxide
- Surgical Sutures and Adhesives
- Cancer Immunotherapy and Biomarkers
- Multiple and Secondary Primary Cancers
- Fermentation and Sensory Analysis
- Adipose Tissue and Metabolism
- Older Adults Driving Studies
- Pain Mechanisms and Treatments
- Nanoplatforms for cancer theranostics
- Erythrocyte Function and Pathophysiology
- Urban Transport and Accessibility
- Hemoglobinopathies and Related Disorders
- Minimally Invasive Surgical Techniques
- Food Drying and Modeling
- Gallbladder and Bile Duct Disorders
- Smoking Behavior and Cessation
Second Affiliated Hospital of Nanchang University
2024-2025
Nanchang University
2015-2025
Northeast Agricultural University
2020-2025
Nanjing Medical University
2024-2025
First Affiliated Hospital of Henan University
2022-2024
Henan Bioengineering Technology Research Center
2022-2024
Central South University
2024
Huazhong University of Science and Technology
2024
Affiliated Hospital of Hangzhou Normal University
2024
Songshan Lake Materials Laboratory
2023-2024
(1) Alzheimer's disease (AD) is a neurodegenerative disorder, and it now widely accepted that neuroinflammation plays key role in its pathogenesis. Eriodictyol (Eri) homoeriodictyol (Hom), dihydroflavonoids extracted from variety of plants, have been confirmed to display relationship with neuroprotection. (2) Methods: An AD mouse model was constructed by intracerebroventricular (ICV) injection the Aβ
Background: Observational studies have reported that arm fat, left leg and trunk fat masses different effects on polycystic ovarian syndrome (PCOS). However, the causal relationship between them remains unknown. Materials Methods: A two-sample Mendelian randomization (MR) study was conducted by utilizing pooled data from largest Genome-Wide Association Study (GWAS). Random effect inverse variance weighted (IVW) method, median (WM), MR-Egger regression analysis were main statistical methods...
Although significant progress has been made in cancer immunotherapy recent years, its overall efficacy remains limited a large number of patients. The interaction between the tumor microenvironment (TME) and CD8+ T cells is one core topics research. can play an anti-tumor role by recognizing killing virus-infected or mutated cells. However, TME, as compresses immune cells, function them impaired, studies have found that relying on PD-1 alone not enough to resist Therefore, blocking Tim-3...
In many solid tumours, including gastric cancer (GC), the beginning and progression of tumour are closely correlated with microbiome. Here, we show changes in microbiota their influence on immune regulation promotion GC through 16s rRNA sequencing single cell RNA sequencing. Streptococcus lutetiensis (S. lutetiensis) was found to be enriched tissues patients. Further analysis using single-cell flow cytometry showed that S. notably affects antitumour immunity by suppressing IL17 signalling...
Changes in nutrient content and bioactivity are important indicators to evaluate the quality of products. Berries rich antioxidant anthocyanins, which prone degradation during drying. The effects different variables on stability anthocyanins berry puree microwave assisted foam-mat drying (MFD) was investigated by path analysis kinetics analysis. experimental results showed that mainly occurred last stage. temperature moisture have both direct indirect anthocyanin stability. coefficient...
Eleven new pyridone alkaloids, penicipyridones A–K (1–11), and three tetramic acids, tolypocladenols D–F (12–14), were isolated from rice media cultures of the marine-derived fungus Penicillium oxalicum QDU1. Their structures, including absolute configurations, determined by comprehensive analyses spectroscopic data, electronic circular dichroism (ECD) calculations, single-crystal X-ray diffraction data. Interestingly, several undergo interconversions between hydroxy methoxy groups at C-4 in...
Subcellular biomineralization systems with cellular intervention functions have shown great potential in cancer theranostic applications. However, the lack of subcellular specificity, high ion concentrations, and long incubation time required for still limit its vivo therapeutic efficacy. Herein, we report a mitochondria-targeted polymer–gold complex (TPPM-Au) to realize mitochondrial biometallization, which involves analogous mechanisms during biomineralization, treatment vivo. The...
Abstract Futoquinol (Fut) is a compound extracted from Piper kadsura that has nerve cell protection effect. However, it unclear whether Fut protective effects in Alzheimer's disease (AD). In this study, we aimed to explore the therapeutic effect of AD and its underlying mechanism. UPLC‐MS/MS method was performed quantify hippocampus mice brain. The cognition ability, neuronal mitochondria damage, levels Aβ 1–42 , 1–40 p‐Tau, oxidative stress, apoptosis, immune cells, inflammatory factors...
Dihydromyricetin (DHM) is a natural dihydroflavonol compound with quite number of important pharmacological properties. However, its low solubility in water and poor stability aqueous environment, have compromised drug efficacy DHM, thus hindering clinical use. The present study was to develop DHM-loaded gastric floating sustained-release tablet (DHM-GFT) improve the bioavailability DHM. DHM-GFT prepared via powder direct compression. formulation optimized terms ability release rate....
Alzheimer's disease (AD) is a progressive with long duration and complicated pathogenesis. Thymidine (Thy) 2'-deoxyuridine (2'-De) are pyrimidines nucleotides that associated nervous system diseases. However, it remains unclear whether Thy 2'-De exert neuroprotective effects in AD. Therefore, this study was conducted to explore the interventional mechanisms of on Aβ25-35-induced brain injury. Donepezil (Do, 10 mg/kg/d), (20 mg/kg/d) were administered for 4 weeks after injection Aβ25-35...
To investigate the effects of β-sitosterol (B-SIT) and underlying mechanisms action in an ovalbumin-induced rat model asthma.The pathological morphological changes lung tracheal tissues were observed by H&E, PAS, Masson's staining. The levels IgE, TNF-α, IFN-γ bronchoalveolar lavage fluid (BALF) those IL-6, TGF-β1, IL-10 serum measured ELISA. relative expression IL-5, IL-13, IL-21, CD11c, CD80, CD86 mRNA tissue examined RT-qPCR. Flow cytometry was performed to assess immune cells, including...
Camellia oil is a traditional Chinese medicine and nutritional food, it one of the best health foods for prevention Alzheimer's disease (AD). The aim this study was to investigate therapeutic effects camellia in AD terms intestinal microbiota lipid metabolism. To assess changes mouse behavior, brain pathology, gut microbiota, PPARs receptors metabolism related proteins tissue, immune cells, levels inflammation brain. integrated results show may improve memory impairment mice by mediating...
Rationale: T-cell-redirecting bispecific antibodies (bsAbs) and trispecific (tsAbs) designed to recognize different epitopes or antigens have emerged as promising cancer therapies.Current approaches are all include another antibody specific the site of primary antibody, molecular structures generally established.However, dimensions target molecule epitope location play a key role in efficiency immunological synapse (IS) formation subsequent activities, therefore connection flexibility these...
Macrophages promote early host responses to infection by releasing pro-inflammatory cytokines, and they are crucial combat amoebiasis, a disease affecting millions of people worldwide. elicit following direct cell/cell interaction Entamoeba histolytica , inducing NLRP3 inflammasome activation with high-output IL-1β/IL-18 secretion. Here, we found that trophozoites could upregulate peroxiredoxins (Prx) expression abundantly secrete Prxs when encountering cells. The C-terminal Prx was...
To improve the texture quality of blue honeysuckle berry (BHB) snack under continuous microwave puffing and obtain suitable process parameters, effects technology such as intensity, ventilation velocity, time, on objective indexes in terms temperature, moisture content, expansion ratio, porosity, hardness, brittleness BHB were investigated via response surface method pore distribution analysis. The results showed that intensity time had highest for indexes. formation depended structure...
Purpose To assess changes in optical quality and visual function children after 3 months of wearing orthokeratology (OK) lenses. Methods A total 25 myopic aged 8–12 years were recruited completed the follow-up study. Optical quality, corneal morphology assessed at baseline follow-ups 1 OK parameters mainly included modulation transfer (MTF) cutoff, objective scattering index (OSI), Strehl ratio (SR) predicted acuities (PVAs). Visual was by acuity, monocular contrast sensitivity (CSF) across...
The protozoan parasite
Rapid and intelligent identification of prostate cancer (PCa) is critical for early diagnosis. Herein, a convenient, reliable, strategy proposed to screen PCa individuals through indirectly quantifying sarcosine (Sar), an indicator PCa, in clinical urine samples. Success achieved by integrating oxidase (SOX) as specific recognition unit; nanozyme-assisted multicolor visualization platform signal reporter. With the Fe-MOFs peroxidase, synergetic action SOX response gold nanorods (Au NRs)...