A5002689283- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Influenza Virus Research Studies
- Virus-based gene therapy research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Herpesvirus Infections and Treatments
- Poxvirus research and outbreaks
- Rabies epidemiology and control
- Disaster Response and Management
- Viral gastroenteritis research and epidemiology
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- SARS-CoV-2 and COVID-19 Research
Chinese Academy of Agricultural Sciences
2023-2025
Jilin Agricultural University
2023-2024
Yangzhou University
2023-2024
Institute of Special Animal and Plant Sciences
2024
Jilin Academy of Agricultural Sciences
2024
Shihezi University
2023-2024
The Ebola virus (EBOV) is a member of the Orthoebolavirus genus, Filoviridae family, which causes severe hemorrhagic diseases in humans and non-human primates (NHPs), with case fatality rate up to 90%. development countermeasures against EBOV has been hindered by lack ideal animal models, as requires handling biosafety level (BSL)-4 facilities. Therefore, accessible convenient models are urgently needed promote prophylactic therapeutic approaches EBOV. In this study, recombinant vesicular...
Introduction The Crimean-Congo hemorrhagic fever virus (CCHFV), the most geographically widespread tick-borne virus, is endemic in Africa, Eastern Europe and Asia, with infection resulting mortality up to 30% of cases. Currently, there are no approved vaccines or effective therapies available for CCHF. CCHFV should only be manipulated BSL-4 laboratory, which has severely hampered basic seroprevalence studies. Methods In present study, two antibody detection methods forms an enzyme-linked...
Clade 2.3.4.4 H5Nx avian influenza viruses (AIVs) have circulated globally and caused substantial economic loss. Increasing numbers of humans been infected with H5N6 AIVs in recent years. Only a few human vaccines licensed to date. However, the live attenuated virus vaccine exhibited potential being recombinant wild-type A (IAV). Therefore, we developed chimeric cold-adapted based on H5 AIVs. These demonstrate advantage non-recombinant IAVs future study. The findings our current study reveal...
Rabies, caused by the Rabies virus (RABV), is a highly fatal zoonotic disease. Existing rabies vaccines have demonstrated good immune efficacy, but complexity of immunization procedures and high cost has impeded elimination RABV, particularly in post-COVID-19 era. There pressing need for safer more effective that streamline vaccination protocols reduce expense. To meet this need, we developed potential vaccine candidate called ALVAC-RABV-VLP, utilizing CRISPR/Cas9 gene editing technology....
Ebola virus disease (EVD) is an acute viral hemorrhagic fever causing thousands of deaths. The large outbreak in 2014–2016 posed significant threats to global public health, requiring the development multiple medical measures for control. Sudan (SUDV) and Zaire (EBOV) are responsible severe occasional deadly outbreaks West Africa Middle Africa. This study shows that bivalent bacterium-like particles (BLPs)-based vaccine, SUDV-EBOV BLPs (S/ZBLP + 2 P), generated by mixing SUDV-BLPs EBOV-BLPs...