A5045165852- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Autophagy in Disease and Therapy
- Facial Trauma and Fracture Management
- Disaster Response and Management
- COVID-19 epidemiological studies
- Reconstructive Surgery and Microvascular Techniques
- Hepatitis B Virus Studies
- Vascular Procedures and Complications
- Respiratory viral infections research
- Toxoplasma gondii Research Studies
Jilin University
2019-2024
Chinese Academy of Agricultural Sciences
2023-2024
Institute of Special Animal and Plant Sciences
2023-2024
Xi'an Jiaotong University
2023
Academy of Military Medical Sciences
2019-2021
Jilin Medical University
2020
The Ebola virus (EBOV) is a member of the Orthoebolavirus genus, Filoviridae family, which causes severe hemorrhagic diseases in humans and non-human primates (NHPs), with case fatality rate up to 90%. development countermeasures against EBOV has been hindered by lack ideal animal models, as requires handling biosafety level (BSL)-4 facilities. Therefore, accessible convenient models are urgently needed promote prophylactic therapeutic approaches EBOV. In this study, recombinant vesicular...
Sudan virus (SUDV) causes severe lethal hemorrhagic fever in humans and nonhuman primates. The most effective economical way to protect against ebolavirus disease is prophylactic vaccination. However, there are no licensed vaccines prevent SUDV infections. In this study, a bacterium-like particle (BLP)-based vaccine displaying the extracellular domain of glycoprotein (eGP) was developed based on gram-positive enhancer matrix-protein anchor (GEM-PA) surface display system. Expression...
Since its first emergence in 2012, cases of infection with Middle East respiratory syndrome coronavirus (MERS-CoV) have continued to occur. At the end January 2020, 2519 laboratory confirmed a case-fatality rate 34.3% been reported. Approximately 84% human reported tropical region Saudi Arabia. The MERS-CoV has highlighted need for rapid and accurate assay triage patients suspected timely manner because lack an approved vaccine or effective treatment prevent control potential outbreaks. In...
The frequent emergence of SARS-CoV-2 variants thwarts the prophylactic and therapeutic countermeasures confronting COVID-19. Among them, Delta variant attracts widespread attention due to its high pathogenicity fatality rate compared with other variants. However, new variants, studies on have been gradually weakened ignored. In this study, a replication-competent recombinant virus carrying S protein was established based vesicular stomatitis (VSV), which presented safe alternative model for...
Ebola disease is a lethal viral hemorrhagic fever caused by ebolaviruses within the Filoviridae family with case fatality rates of up to 90%. Monoclonal antibody (mAb) based therapies have shown great potential for treatment EVD. However, emerging ebolavirus isolates and negative effect decoy protein (secreted glycoprotein, sGP) on therapeutic efficacy antibodies highlight necessity developing novel counter threat Ebola. Here, 11 fully human mAbs were isolated from transgenic mice immunized...
Bax-interacting factor-1 (Bif-1) is a multifunctional protein involved in apoptosis, autophagy, and mitochondrial morphology. However, the associations between Bif-1 viruses are poorly understood. As discrete isoforms selectively expressed exert corresponding effects, we evaluated effects of neuron-specific/ubiquitous on rabies virus (RABV) proliferation. First, infection with RABV CVS-11 strain significantly altered expression mouse neuroblastoma (N2a) cells, knockdown turn promoted...
Ebola virus disease (EVD) is an acute viral hemorrhagic fever causing thousands of deaths. The large outbreak in 2014–2016 posed significant threats to global public health, requiring the development multiple medical measures for control. Sudan (SUDV) and Zaire (EBOV) are responsible severe occasional deadly outbreaks West Africa Middle Africa. This study shows that bivalent bacterium-like particles (BLPs)-based vaccine, SUDV-EBOV BLPs (S/ZBLP + 2 P), generated by mixing SUDV-BLPs EBOV-BLPs...
To investigate the accuracy and reliability of augmented reality (AR) technique in locating perforating vessels posterior tibial artery during repair soft tissue defects lower limbs with perforator flap.Between June 2019 2022, flap was used to skin around ankle 10 cases. There were 7 males 3 females an average age 53.7 years (mean, 33-69 years). The injury caused by traffic accident 5 cases, bruising heavy weight 4 machine 1 case. size wound ranged from cm×3 cm 14 cm×7 cm. interval between...
Since its first emergence in 2012, cases of infection with Middle East respiratory syndrome coronavirus (MERS-CoV) have continued to occur. In this study, we present two nucleic acid visualization assays that target the MERS-CoV UpE and N genes as a panel combines reverse transcription recombinase polymerase amplification closed vertical flow strip (RT-RPA-VF). The limit detection was 1.2×10^1 copies/μl for assay 1.2 assay. exhibited no cross-reactivity multiple CoVs, including bat severe...