A5090125999- Rabies epidemiology and control
- Microbial Community Ecology and Physiology
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Viral Infections and Immunology Research
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- Venomous Animal Envenomation and Studies
- Viral-associated cancers and disorders
- Animal Disease Management and Epidemiology
- Genomics and Phylogenetic Studies
- interferon and immune responses
- Cellular transport and secretion
- Erythrocyte Function and Pathophysiology
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Hemoglobinopathies and Related Disorders
- Poxvirus research and outbreaks
- Virology and Viral Diseases
- Photosynthetic Processes and Mechanisms
- Circular RNAs in diseases
Jilin University
2014-2025
Nanjing University of Chinese Medicine
2017-2024
Beijing Academy of Agricultural and Forestry Sciences
2022-2024
Institute of Grassland Research
2022-2023
Beijing Forestry University
2021-2022
Nanjing Traditional Chinese Medicine Hospital
2021
Hebei Medical University
2020
Nanjing Medical University
2009-2012
Interleukin-8 (IL-8) possesses tumorigenic and proangiogenic properties, is overexpressed in many human cancer types. However, only few studies have demonstrated the mechanisms of action IL‑8 regarding ability to promote proliferation inhibit apoptosis prostate cancer. Here, aim present study was investigate effects on cell line determine possible underlying its effect. In this study, shown be significantly upregulated compared with paired normal control tissues. The data showed that...
Abstract Bovine enterovirus, a member of the Enterovirus genus in Picornaviridae family, causes severe digestive and respiratory illnesses cattle. These threaten healthy development cattle industry. Innate immunity plays critical role resisting viral infections, but viruses also use various strategies to evade or counteract host’s immune system. The mechanisms by which bovine enteroviruses host response promote their replication remain unclear. This study used HY12 strain enterovirus as...
The etiology of glioma remains unclear so far. Human herpesvirus 6 (HHV-6) might be associated with glioma, but there is no direct evidence to support this. High percentages HHV-6 DNA and protein were detected in tissue from gliomas, compared normal brain tissue. In addition, a strain HHV-6A was isolated the fluid specimens cysts. levels interleukin (IL-6), 8 (IL-8), tumor necrosis factor α, transforming growth β (TGF-β) cyst HHV-6–positive patients glioma. Furthermore, infection promoted...
Breast cancer is one of the most frequently occurring cancers in women. In recent years, Dendrobium candidum has played a part antihyperthyroidism and anticancer drugs. This study aims to examine antitumor effect D. on breast cancer.Human cell line MCF-7 normal epithelial MCF10A were used observe effects treatment human cancer. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was employed proliferation cells. Western blot analysis reverse transcription polymerase...
Abstract Although the expression of thousands host long noncoding RNAs (lncRNAs) can be regulated by viral infection, number lncRNAs with experimentally verified function is limited. In this study, lncRNA TSPOAP1‐AS1 was significantly induced influenza A virus (IAV) infection in a dose‐ and time‐dependent manner. Polyinosine‐polycytidylic acid (poly (I:C)), synthetic analog double‐stranded RNA, also increased expression. RNA fractionation revealed that nucleocytoplasmic lncRNA, an...
Background: Honokiol is one of the main bioactive constituents traditional Chinese herbal drug Magnolia bark (Cortex Magnoliae officinalis , Hou Po). The aim this study was to probe its anti-type 2 diabetes mellitus effects and underlying mechanism. Methods: Type diabetic mouse model established by intraperitoneally injecting with streptozotocin. Fasting blood glucose, body weight, lipid profile were measured. subcutaneous adipose tissue, skeletal muscle, liver isolated as well homogenized....
The degradation of chlorophyll is great significance to plant growth. b reductase NOL (NYC1-like) in charge catalyzing the and maintaining stability photosystem. However, molecular mechanisms NOL-mediated degradation, senescence, photosynthesis its functions other metabolic pathways remain unclear, especially warm-season turfgrass. In this study, ZjNOL was cloned from Zoysia japonica. It highly expressed senescent leaves. Subcellular localization investigation showed localized chloroplast...
Rabies is a fatal zoonotic disease that poses threat to public health. virus (RABV) excreted in the saliva of infected animals, and primarily transmitted by bite. The role salivary glands propagation significant, but has been less studied pathogenic mechanisms RABV. To identify functionally important genes glands, we used RNA sequencing (RNA-seq) establish analyze mRNA expression profiles parotid tissue with two RABV strains, CVS-11 PB4. biological functions differentially expressed (DEGs)...
Enteroviruses are the causative agents associated with several human and animal diseases, posing a significant threat to health. As one of host immune defense strategies, innate immunity plays crucial role in defending against invading pathogens, where utilizes variety mechanisms inhibit or eliminate pathogen. Here, we report new strategy for repress enterovirus replication by 78 kDa glucose-regulated protein (GRP78), also known as heat shock family A member 5 (HSPA5). The GRP78 recognizes...
Rabies virus (RABV) is highly lethal and triggers severe neurological symptoms. The neuropathogenic mechanism remains poorly understood. Ras-related C3 botulinum toxin substrate 1 (Rac1) a Rho-GTPase that involved in actin remodeling has been reported to be closely associated with neuronal dysfunction. In this study, by means of combination pharmacological inhibitors, small interfering RNA, specific dominant-negatives, we characterize the crucial roles dynamic regulatory function Rac1 RABV...
Background: The transcription factor GATA-2 is predominantly expressed in hematopoietic stem and progenitor cells counteracts the erythroid-specific GATA-1 , to modulate proliferation differentiation of cells. During cell differentiation, exhibits dynamic expression patterns, which are regulated by multiple factors. Methods: Stable LSD1-knockdown lines were established growing murine erythroleukemia (MEL) or mouse embryonic together with virus particles, presence Polybrene ® at 4 µg/mL, for...
Zoysia japonica is an important warm-season turfgrass used worldwide. Although the draft genome sequence and a vast amount of next-generation sequencing data have been published, current annotation complete mRNA structure remain incomplete. Therefore, to analyze full-length transcriptome Z. japonica, we PacBio single-molecule long-read method in this study.First, generated 37,056 high-confidence non-redundant transcripts from 16,005 gene loci. Next, 32,948 novel transcripts, 913 loci, 8035...
The pattern recognition receptor retinoic acid-inducible gene I (RIG-I) reportedly plays a key role in sensing influenza A virus (IAV) infection and activating type interferon (IFN) response. MCP-1-induced protein 1 (MCPIP1) can directly degrade cytokine mRNAs, such as IL-6, IL-12, IL-1β, IL-2, by functioning an RNase. Here, we initially observed that MCPIP1 exhibited supportive functions later the course of IAV A549 cells, negatively regulated IAV-induced RIG-I-dependent innate antiviral...
Pennisetum species have importance in foraging, agriculture, energy-production, the environment, and landscaping. To promote preservation utilization of ornamental resources, we developed simple sequence repeat (SSR) markers from setaceum cv. ‘Rubrum’ transcriptome verified their conservation 38 sources. Our sequencing efforts generated 58.91 Gb clean data containing 55,627 unigenes. We functionally annotated 30,930 unigenes, with functions enriched translation ribosomal structure...
Abstract Human herpesvirus 6 (HHV‐6) is a beta‐herpesvirus capable of infecting cells from different origin. In this study, infection with HHV‐6A human embryonic fibroblasts (HEFs) was performed. Infected showed obvious cytopathic effects (CPE). PCR and immunohistochemical tests also confirmed that HEFs are susceptible to infection. The biological on were studied. decreased proliferation as measured by [ 3 H] thymidine incorporation cell counting. Further analysis demonstrated leads cycle...
ABSTRACT Bovine enterovirus (BEV) consisting of species E (EV-E) and F (EV-F) is the causative agent associated with respiratory gastrointestinal diseases in cattle. Here, we reported characterization, genetic diversity, recombination novel BEV strains isolated from major cattle-raising regions China during 2012–2018. Twenty-seven were successfully characterized. Molecular characterization demonstrated that majority these (24/27) EV-E, while only few (3/27) EV-F. Sequence analysis revealed...