A5101919869- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Circular RNAs in diseases
- Cancer-related gene regulation
- Nitric Oxide and Endothelin Effects
- Nanoplatforms for cancer theranostics
- Optical Coherence Tomography Applications
- Microbial Metabolic Engineering and Bioproduction
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Ear Surgery and Otitis Media
- Cancer, Stress, Anesthesia, and Immune Response
- MXene and MAX Phase Materials
- Radiopharmaceutical Chemistry and Applications
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cardiac Ischemia and Reperfusion
- Cutaneous Melanoma Detection and Management
- Neuropeptides and Animal Physiology
- melanin and skin pigmentation
- PARP inhibition in cancer therapy
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Nottingham University Hospitals NHS Trust
2023-2025
Southern Medical University
2025
Zhujiang Hospital
2025
Zhengzhou Normal University
2025
National Heart Lung and Blood Institute
2025
Tsinghua University
2024
China Academy of Art
2024
Shandong University
2012-2024
Liaoning Technical University
2024
Acute myocardial infarction (MI) is the leading cause of death worldwide. Exogenous delivery nitric oxide (NO) to infarcted myocardium has proven be an effective strategy for treating MI due multiple physiological functions NO. However, reperfusion blood flow ischemic tissues accompanied by overproduction toxic reactive oxygen species (ROS), which can further exacerbate tissue damage and compromise therapeutic efficacy. Here, injectable hydrogel synthesized from chitosan modified...
Abstract Nitric oxide (NO) is a short-lived signaling molecule that plays pivotal role in cardiovascular system. Organic nitrates represent class of NO-donating drugs for treating coronary artery diseases, acting through the vasodilation systemic vasculature often leads to adverse effects. Herein, we design nitrate-functionalized patch, wherein nitrate pharmacological functional groups are covalently bound biodegradable polymers, thus transforming small-molecule into therapeutic...
Cancer cells outcompete tumor-infiltrating T lymphocytes (TILs) for glucose uptake, manipulating a glucose-deprived tumor microenvironment (TME) with high accumulation of lactate, which impairs CD8+ TIL effector function, however supports the immune suppression regulatory (Treg) cells. Aerobic glycolysis inhibition coupled mitochondrial dysfunction in cancer may reprogram TME to destabilize Treg and, more importantly, facilitate cell activation and cytotoxic killing. Here, sono-metabolic...
In contrast to cytoplasmic localization of spliced mRNAs, many lncRNAs are localized in the nucleus. To investigate mechanism, we used lncRNA MEG3 as a reporter and mapped potent nuclear retention element (NRE), deletion this led striking export from nucleus cytoplasm. Insertion NRE resulted well mRNA. We further purified RNP assembled on vitro identified proteins by mass spectrometry. Screen using siRNA revealed depletion U1 snRNP components SNRPA, SNRNP70 or SNRPD2 caused significant...
Metastatic castration-resistant prostate cancer (mCRPC) is one of the main contributors to death patients. To date, detailed molecular mechanisms underlying mCRPC are unclear. Given crucial role epithelial–mesenchymal transition (EMT) in metastasis, we aimed analyse expression and function Transforming growth factor-beta (TGF-β) signal-associated protein named Sox5 mCRPC. The levels were analysed by western blot, immunohistochemistry immunofluorescence. Luciferase reporter assays chromatin...
This study investigated the hypoglycemic and renal protective effects of scutellarin (SCU) in db/db mice elucidated underlying mechanisms. The oral administration metformin hydrochloride (Met) at 120 mg/kg SCU 25, 50, 100 over an eight-week period had effects, demonstrated by decreases body weight, blood glucose, food water intake, glycated hemoglobin activity augmented insulin levels pyruvate kinase serum mice. alleviated dyslipidemia decreasing triglycerides total cholesterol enhancing...
Here, we undertaked a comprehensive investigation into the geometric structures, spectral and electronic properties of MB2n− (M=V, Cr, Ni; n=8-12) clusters. Initially, employing first-principles calculations alongside CALYPSO structure search algorithm, optimized global minimum structures for B2n− A comparative analysis elucidated that incorporation transition metal atoms induces complete structural rearrangement pure boron clusters, leading to formation drum-like cage-like respectively....
Abstract Ferroptosis is a recently proposed type of programmed cell death, associated with variety diseases including tumors. Researchers have thereby presented nanoplatforms to mediate ferroptosis for anti-cancer therapy. However, the development ferroptosis-based nanotherapeutics was hindered by limited penetration depth in tumors, poor active pharmaceutical ingredient loading content (API) and systemic toxicity. Herein, self-propelled nanoinducers composed two endogenous proteins, glucose...
Rationale: Glioblastoma multiforme (GBM) is the most aggressive primary malignant brain tumor in adults, characterized by high invasiveness and poor prognosis. Glioma stem cells (GSCs) drive GBM treatment resistance recurrence, however, molecular mechanisms activating intracranial GSCs remain unclear. Extracellular vesicles (EVs) are crucial signaling mediators regulating cell metabolism can cross blood-brain barrier (BBB). This study aimed to elucidate how EV cargo contributes GSC state...
The plasminogen activator system is critically involved in tumor progression regulation. Aberrant activation of urokinase‐type (uPA) induces proteolytic degradation cellular membranes and the extracellular matrix, thereby promoting invasion metastasis. Consequently, uPA has emerged as a promising diagnostic therapeutic target. Herein, we designed evaluated three cyclic peptide‐based radioligands ([⁶⁴Cu]CAP‐1, [⁶⁴Cu]CAP‐2, [⁶⁴Cu]CAP‐3) potential PET tracers for visualization murine models,...
Lipoprotein lipase (LPL) carries out the lipolytic processing of triglyceride-rich lipoproteins (TRL) along luminal surface capillaries. LPL activity is regulated by angiopoietin-like proteins (ANGPTL3, ANGPTL4, ANGPTL8), which control delivery TRL-derived lipid nutrients to tissues in a temporal and spatial fashion. This regulation mediates partitioning adipose tissue striated muscle according nutritional status. A complex between ANGPTL3 ANGPTL8 (ANGPTL3/8) inhibits oxidative tissues, but...
Xeroderma pigmentosum group A (XPA)-binding protein 2 (XAB2) is a multi-functional that plays critical role in processes including transcription, transcription-coupled DNA repair, pre-mRNA splicing, homologous recombination and mRNA export. Microarray analysis on gene expression XAB2 knockdown cells reveals many genes with significant change function mitotic cell cycle regulation. Fluorescence-activated scanner confirmed depletion led to arrest G2/M phase, mostly at prophase or prometaphase....
Castration-resistant prostate cancer (CRPC) with neuroendocrine differentiation (NED) is a lethal disease for which effective therapies are urgently needed. The mechanism underlying development of CRPC NED, however, remains largely uncharacterized. In this study, we explored and characterized the functional role neurotensin (NTS) in cell line animal models NED. NTS was acutely induced by androgen deprivation (PCa) activated downstream signaling leading to NED through activation receptor 1...
Cell therapy by autologous mesenchymal stem cells (MSCs) is a clinically acceptable strategy for treating various diseases. Unfortunately, the therapeutic efficacy largely affected low quality of MSCs collected from patients. Here, we showed that gene expression patients with diabetes was differentially regulated compared to healthy controls. Then, were genetically engineered catalyze an NO prodrug release intracellularly. Compared extracellular conversion, intracellular delivery effectively...
Melanoma is a malignant tumor.The acquisition of stemness by melanoma cells aggravates the transformation, which can be regulated microRNAs (miRNAs, miR).MiR-363-3p key tumor-related miRNA, but its role in and still unknown.Presently, miR-363-3p induced hypoxia inducible factor (HIF)-2α has positive cell stemness.The levels HIF-2α are upregulated lines.Overexpression significantly increased miR-363-3p.However, both knockdown inhibition decreased markers (CD133, CD271, Jarid1B...
Abstract Background Radiation therapy (RT) with androgen deprivation (ADT) is an effective to suppress the locally advanced prostate cancer (PCa). However, we unexpectedly found that RT could also induce receptor splice variant 7 (ARv7) expression decrease radiosensitivity . Methods The study was designed target ARv7 Quercetin or ARv7-shRNA leads enhancing and increasing radiation sensitivity better PCa involved modulation of circNHS/miR-512-5p/XRCC5 signaling. Results Mechanism studies...