A5100708910- Head and Neck Cancer Studies
- Proteins in Food Systems
- Biochemical effects in animals
- Liver Disease Diagnosis and Treatment
- Food composition and properties
- Nanoplatforms for cancer theranostics
- Inhalation and Respiratory Drug Delivery
- Lipid Membrane Structure and Behavior
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Cytomegalovirus and herpesvirus research
- Salivary Gland Tumors Diagnosis and Treatment
- Liver physiology and pathology
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Vibrio bacteria research studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Phytochemicals and Antioxidant Activities
- Hepatitis B Virus Studies
- Phytochemistry and Bioactivity Studies
- Metabolomics and Mass Spectrometry Studies
- Inflammasome and immune disorders
Sichuan Normal University
2025
Zhejiang University of Technology
2023-2025
Nanjing University of Chinese Medicine
2023-2025
Jiangnan University
2024
China Pharmaceutical University
2023-2024
Nanjing Agricultural University
2024
Guangzhou Medical University
2018-2024
Second Affiliated Hospital of Zhejiang University
2021-2023
Seoul National University Bundang Hospital
2023
Seoul National University
2023
Ferroptosis is a novel form of programmed cell death impelled by iron-dependent lipid peroxidation, which may be potential strategy for cancer therapy. Here we demonstrated the first time that Resveratrol (RSV), traditional Chinese medicine (TCM) chemical monomer, could effectually inhibit growth colon cells through ROS-dependent ferroptosis pathway. Mechanistically, RSV evoked increase reactive oxygen species and peroxidation in colorectal cells, eventually lead to ferroptosis. Furthermore,...
Zein, a class of alcohol-soluble prolamines in maize endosperm, is mainly composed α-zein, β-zein, and γ-zein. It has been recognized as structural protein for various gluten-free systems since it can form gluten-like viscoelastic network. The formation zein network make up the defect doughs caused by lack gluten. To most functionality foods, important to clearly elucidate fundamental properties In this article, these have discussed, analyzed summarized from relationship between zein,...
Bupleurum chinense(B. chinense) is a plant that widely distributed globally and has strong pharmacological effects. Though the chloroplast(cp) genome of B. chinense been studied, no reports regarding mitochondrial(mt) have published yet.The mt B.chinense was assembled functionally annotated. The circular 435,023 bp in length, 78 genes, including 39 protein-coding 35 tRNA 4 rRNA were Repeat sequences analyzed sites at which RNA editing would occur predicted. Gene migration observed to between...
The outbreak of SARS-CoV-2 (SARS2) has caused a global COVID-19 pandemic. spike protein SARS2 (SARS2-S) recognizes host receptors, including ACE2, to initiate viral entry in complex biomechanical environment. Here, we reveal that tensile force, generated by bending the cell membrane, strengthens recognition ACE2 and accelerates detachment spike's S1 subunit from S2 rapidly prime fusion machinery. Mechanistically, such mechano-activation is fulfilled force-induced opening rotation...
Acetaminophen induced acute liver injury (ALI) has a high incidence and is serious medical problem, but there lack of effective treatment. The enterohepatic axis one the targets recent attention due to its important role in diseases. Disulfiram (DSF) multitarget drug that been proven play variety diseases can affect intestinal flora, whether it alleviate ALI not clear. We utilised bacterial 16S rRNA gene profiling, antimicrobial treatments, faecal microbiota transplantation tests explore DSF...
The global prevalence of allergic rhinitis (AR) remains high, posing challenges due to its chronic nature and propensity for recurrence. Gut microbiota dysbiosis contributes immune dysregulation, impacting AR pathogenesis. Limosilactobacillus reuteri (L. reuteri) has great potential in regulating function alleviate symptoms. However, the specific active components mechanisms underlying therapeutic effects remain incompletely clarified. This study aimed explore L. metabolites alleviating AR....
Pulmonary fibrosis (PF) is characterized by dense collagen and mucus barriers that significantly limit drug delivery to the lungs. Clearing barrier can enhance efficiency. Nevertheless, heterogeneity of states among patients poses a challenge. Therefore, real-time monitoring clearance status essential for PF personalized therapy. Herein, sequential theranostic platforms are proposed targeting magnetic resonance imaging (MRI) guide small interfering RNA (siRNA) delivery. First,...
This study investigated the hypoglycemic and renal protective effects of scutellarin (SCU) in db/db mice elucidated underlying mechanisms. The oral administration metformin hydrochloride (Met) at 120 mg/kg SCU 25, 50, 100 over an eight-week period had effects, demonstrated by decreases body weight, blood glucose, food water intake, glycated hemoglobin activity augmented insulin levels pyruvate kinase serum mice. alleviated dyslipidemia decreasing triglycerides total cholesterol enhancing...
Osteoporosis is a metabolic disease characterized by reduced osteoblast differentiation and proliferation.Oxidative stress plays role in the pathogenesis of osteoporosis.Aucubin (AU), an iridoid glycoside, was previously shown to promote differentiation.We investigated effects AU on MG63 human osteoblast-like cells treated with dexamethasone (Dex) or hydrogen peroxide (H 2 O ) induce oxidative damage.AU protected against apoptosis, promoted increased expression cytokines associated...
Background/Aim: Chitosan-based functional materials have attracted considerable attention worldwide for applications in wound healing, especially skin due to their efficiency hemostasis, anti-bacterial, and regeneration. Various chitosan-based products been developed healing applications, but most of these face limitations either efficacy or cost-effectiveness. Therefore, there is a need develop unique material that can handle all concerns be utilized acute chronic wounds. This study...
Abstract Purpose This research was conducted to investigate the potential of short-chain fatty acids (SCFAs) in protecting organs from heat stress-induced injuries and gut microbiota modulation. Methods Sprague–Dawley rats were randomly assigned various groups including a control group, room temperature training hyperthermia SCFAs pretreatment recipients received feces HT group. After strenuous at high temperatures, levels plasma enzymes AST, ALT, BUN, Cr evaluated. The changes fecal...
Glioblastoma multiforme (GBM), a highly invasive and prognostically challenging brain cancer, poses significant hurdle for current treatments due to the existence of blood-brain barrier (BBB) difficulty maintain an effective drug accumulation in deep GBM lesions.
Abstract Alphaherpesviruses are large dsDNA viruses with an ability to establish persistent infection in hosts, which rely partly on their evade host innate immune responses, notably the type I IFN response. However, relevant molecular mechanisms not well understood. In this study, we report UL42 proteins of alphaherpesvirus pseudorabies virus (PRV) and HSV 1 (HSV1) as a potent antagonist IFN-I–induced JAK-STAT signaling pathway. We found that ectopic expression porcine macrophage CRL human...