A5079370510- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- HIV Research and Treatment
- Adolescent and Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Maternal Mental Health During Pregnancy and Postpartum
- HIV/AIDS drug development and treatment
- Adolescent Sexual and Reproductive Health
- Family Support in Illness
- Palliative Care and End-of-Life Issues
- Religion, Spirituality, and Psychology
- Grief, Bereavement, and Mental Health
- Pharmacological Effects and Toxicity Studies
- Bipolar Disorder and Treatment
- Cognitive Functions and Memory
- Homelessness and Social Issues
- Gestational Diabetes Research and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Impact on Reproduction
- Attention Deficit Hyperactivity Disorder
- Pregnancy and Medication Impact
- Age of Information Optimization
- Religion, Society, and Development
- Hemoglobinopathies and Related Disorders
- Poverty, Education, and Child Welfare
Swiss HIV Cohort Study
2024
Children's Diagnostic & Treatment Center
2014-2023
Baylor College of Medicine
2017
Harvard University
2015
St. Jude Children's Research Hospital
2001-2013
Northwestern University
2013
Tulane University
2008-2013
University of Fort Lauderdale
2013
Memphis Health Center
2013
SleepMed
2011
Mental health problems (MHPs) among children with perinatal HIV infection have been described prior to and during the highly active antiretroviral therapy (HAART) era. Yet child, caregiver socio-demographic factors associated MHPs are not fully understood. We examined prevalence of older adolescents exposure, including both perinatally HIV-infected (PHIV +) HIV-exposed but uninfected (PHEU) youth. Our aims were identify impact by comparing PHIV + PHEU youth delineate risk MHPs, in order...
The influence of disease severity on cognitive and adaptive functioning in perinatally HIV-infected youth with (PHIV+/C) without (PHIV+/NoC) a previous AIDS-defining illness (Centers for Disease Control Prevention Class C event), compared HIV-exposed but uninfected (PHEU) is not well understood.This was cross-sectional analysis PHIV+/C (n = 88), PHIV+/NoC 270) PHEU 200) aged 7-16 years, from multisite prospective cohort study. Youth caregivers completed the Wechsler Intelligence Scale...
The purpose of this research was to test the effectiveness a model family/adolescent-centered advance care planning for adolescents living with HIV and their families increasing congruence quality communication while decreasing decisional conflict.Ours 2-group, randomized, controlled trial in 2 hospital-based outpatient clinics Washington Memphis from 2006 2008. Participants (N = 38 dyads) included medically stable aged 14 21 years HIV/AIDS surrogates/families > or =21 years. Three 60-...
OBJECTIVE: Nonadherence to antiretroviral therapy among children/youth with HIV often is associated disease progression. This study examined the agreement between child and caregiver perceptions of barriers adherence factors these barriers. METHODS: Children/youth perinatally acquired their parents/caregivers (n = 120 dyads) completed a questionnaire about 19 potential child’s regimen. Agreement 2 reports was measured via kappa statistic. Factors were assessed by using multiple logistic...
It is unknown if religiousness/spirituality influences end-of-life treatment preferences among adolescents. Investigators assessed whether moderates the relationship between an advance care planning intervention and 85 primarily African-American adolescents living with HIV/AIDS in outpatient-hospital-based HIV-specialty clinics United States. Adolescents aged 14–21 years their families were randomized to three-weekly-60-minute sessions either: (survey, goals of conversation, directive); or...
We aimed to retrospectively assess the efficacy of pill-swallowing training provided as a clinical intervention referred pediatric patients with HIV in relation improved adherence and subsequent related health outcomes. The primary goal this study was demonstrate participation is associated medication documented by routine pharmacy pill counts. Secondary objectives were corresponding improvements clinically observed biologic indicators adherence, specifically, immunologic functioning (CD4+...
To develop, adapt, and ensure feasibility, acceptability, safety of the Family/Adolescent-Centered (FACE) Advance Care Planning intervention.Two-group, randomized, controlled trial in two hospital-based outpatient clinics Washington, D.C. Memphis, Tennessee, from 2006 to 2008 was conducted. Participants (n = 38 dyads) included medically stable adolescents aged 14 21 years with HIV/AIDS surrogates/families over age 20. Three 60- 90-minute sessions were conducted via a semistructured family...
This study evaluated effects of perinatal exposure to antiretroviral (ARV) medications on neurodevelopment HIV-exposed, uninfected infants.HIV-exposed, infants (age 9-15 months) enrolled in Surveillance Monitoring for Antiretroviral Therapy Toxicities, a multisite prospective surveillance study, completed the Bayley Scales Infant and Toddler Development-Third Edition (Bayley-III), assessing cognition, language, motor skills, social-emotional development adaptive behavior. Linear regression...
To identify factors associated with nonadherence and unsuppressed viral load across adolescence among youth perinatally acquired HIV.Longitudinal study at 15 US clinical sites.Self-reported antiretroviral medication (any missed dose, past week) (HIV RNA > 400 copies/ml) were assessed annually. Individual, caregiver, social, structural identified by age (years): 8-11 (preadolescence), 12-14 (early adolescence), 15-17 (middle 18-22 (late adolescence/young adulthood), utilizing multivariable...
Patients with severe sickle cell anemia (SCA) may benefit from therapeutic intervention hydroxyurea (HU), chronic red transfusion (CT), or stem transplantation (SCT). Determination of best treatment is complicated by the tradeoff between each treatment's risks and benefits lack data comparing them to determine efficacy. We explored factors that influenced making decisions regarding interventions examined relations preference health-related quality life (HRQOL).Children SCA their parents...
The objective of this study is to determine if pediatric advance care planning (pACP) increases adolescent/family congruence in end-of-life (EOL) treatment preferences longitudinally. Adolescents aged 14-21 years with HIV/AIDS and their families were randomized (N = 105 dyads) three-60-minute sessions scheduled one week apart: either the pACP intervention (survey administered independently, facilitated conversation adolescent family present, completion legal directive document present) or an...
To evaluate achievement in youth with perinatally acquired HIV (PHIV) compared HIV-exposed uninfected peers (HEU) and to examine differential effects of on cognition-achievement concordance.Cognition were assessed using standardized measures. Intelligence quotient-derived predicted scores subtracted from observed calculate discrepancy values. Linear regression models used compare discrepancies between PHIV HEU, adjusting for demographic covariates.295 167 HEU youth; 71% black, 48% male, mean...
The purpose of the study is to describe allocation responsibility for illness management in families children and adolescents perinatally infected with HIV.A total 123 youth (ages 8-18) caregivers completed family medication adherence questionnaires as part a substudy Pediatric AIDS Clinical Trials Group protocol 219c.Approximately one-fourth reported being fully responsible taking medications. A smaller percentage full responsibility. Older older higher degree medication-related tasks,...
Objective To apply a social ecological model to explore the psychosocial factors prospectively associated with longitudinal adherence antiretroviral treatment in youth perinatally infected HIV. Methods Randomly selected youth, age 8 <19 years old, completed cognitive testing and questionnaires at baseline as part of multisite protocol (N = 138). A validated caregiver-report measure was 24 48 weeks after baseline. Results In multivariate analysis, awareness HIV status, caregiver not fully...
Early antiretroviral therapy (ART) limits proviral reservoirs, a goal for human immunodeficiency virus type 1 (HIV-1) remission strategies. Whether this is an immediate or long-term effect of virologic suppression (VS) in perinatal infection unknown. We quantified HIV-1 DNA longitudinally up to 14 years peripheral blood mononuclear cells (PBMCs) among 61 perinatally HIV-1–infected youths the Pediatric HIV/AIDS Cohort Study who achieved VS at different ages. Participants group (n = 13) were...
Preliminary test of a manualized, measurement-guided treatment for depression adolescents and young adults in care at 4 sites the Adolescent Trials Network HIV/AIDS Interventions. The US were randomly assigned to either 24-week, combination cognitive behavioral therapy medication management algorithm (COMB) tailored youth living with HIV (YLWH) or as usual (TAU). Youth TAU had access therapists needed. COMB-site clinicians trained manualized intervention participated supervision calls...
Studies from multiple countries have suggested impaired immunity in perinatally human immunodeficiency virus (HIV)-exposed uninfected children (HEU), with elevated rates of all-cause hospitalization and infections. We estimated compared the incidence infection-related first 2 years life among HEU HIV-unexposed (HUU) United States. Among HEU, we evaluated associations maternal HIV disease-related factors during pregnancy risk child hospitalization.
Youth perinatally HIV infected (PHIV) or exposed, but uninfected (PHEU), are aging into adolescence and adulthood with multiple complex risk factors for mental health (MH) problems poor MH treatment utilization. Our aims were to estimate prevalence of diagnoses, clinically significant symptoms, utilization among youth PHIV PHEU youth, 10–22 years old. We also aimed identify correlates diagnoses Analyses data from standardized interviews, behavioral assessments, chart review 551 revealed that...
Background: Parent/caregiver or child/youth self-report and pill counts are commonly used methods for assessing adherence to antiretroviral therapy among children youth with HIV. The purpose of this study was compare these different one another viral load. Methods: Randomly selected parent/caregiver dyads were interviewed using several measures an announced count performed. Adherence assessment compared their relative validity assessed by comparison the child's load close time interview...
Background: Perinatal HIV (PHIV) infection may place youth at risk for impairments in executive functioning (EF). We examined associations of EF with infection, disease severity and other factors among PHIV perinatally HIV-exposed, uninfected (PHEU). Methods: Within the US-based Pediatric HIV/AIDS Cohort Study, 354 200 PHEU completed a standardized measure (Children's Color Trails Test, CCTT) and/or caregivers questionnaire measuring everyday (Behavior Rating Inventory Executive Function,...
Perinatally acquired HIV (PHIV) confers risk for neurocognitive impairment, which potentially affects school performance and functional independence of infected children. In this study, we examined the associations 2 key domains, memory executive function (EF), with academic adaptive skills among youth PHIV perinatally HIV-exposed but uninfected (PHEU) youth. Participants ages 9 to <19 years enrolled in Pediatric HIV/AIDS Cohort Study's Memory Executive Functioning Study completed...