A5005639902- Cancer Immunotherapy and Biomarkers
- PARP inhibition in cancer therapy
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Brain Metastases and Treatment
- Advanced X-ray Imaging Techniques
- Venous Thromboembolism Diagnosis and Management
- Bacteriophages and microbial interactions
- Mycobacterium research and diagnosis
- Immunotherapy and Immune Responses
- Antimicrobial Peptides and Activities
- Viral Infections and Vectors
- Radiopharmaceutical Chemistry and Applications
- Respiratory viral infections research
- Antibiotic Resistance in Bacteria
- Viral Infections and Outbreaks Research
- CAR-T cell therapy research
- Asthma and respiratory diseases
China-Japan Friendship Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
XinHua Hospital
2016-2024
Chinese Academy of Agricultural Sciences
2022-2024
Jilin University
2022-2024
Taiyuan University of Technology
2024
Beijing Normal University
2024
Peking University Shenzhen Hospital
2017-2024
Southern Medical University
2014-2023
Nanfang Hospital
2014-2023
Although tumor mutation burden (TMB) has been well known to predict the response immune checkpoint inhibitors (ICI), lack of randomized clinical trial data restricted its application. This study aimed explore significance and feasibility biomarker combination based on TMB copy-number alteration (CNA) for prognosis each prediction ICI therapy in metastatic pan-cancer milieu.Non-ICI-treated MSK cohort was used analysis. Three independent immunotherapy cohorts, including non-small cell lung...
Microsatellite instability (MSI) has been approved as a pan-cancer biomarker for immune checkpoint blockade (ICB) therapy.However, current MSI identification methods are not available all patients.We proposed an ensemble multiple instance deep learning model to predict microsatellite status based on histopathology images, and interpreted the pathomics-based with multi-omics correlation.Methods: Two cohorts of patients were collected, including 429 from The Cancer Genome Atlas (TCGA-COAD) 785...
Abstract Chemotherapy and radiotherapy predominantly improve the clinical outcomes of patients with human papillomavirus (HPV)-related head neck squamous cell carcinoma (HNSCC). Whether this superiority goes on when treated immune checkpoint inhibitors is still unclear. This study sought to determine predictive value potential mechanisms HPV status for treatment programmed death 1 (PD-1)/ligand 1(PD-L1) inhibitors. We conducted an integrated analysis relationships between PD-L1, tumor...
Summary The development of chemoresistance may reduce the efficacy chemotherapeutic drugs for treating hepatocellular carcinoma (HCC). In present study, effects apigenin on intensifying chemosensitivity HCC cells and an xenograft model in response to 5‐fluorouracil (5‐FU) were investigated. Sub‐toxic concentrations (4 μ mol/L) significantly enhanced cytotoxicity 5‐FU (100 g/mL) cells. vivo , combined treatment with (20 mg/kg, five times/week 3 weeks) mg/kg 5 consecutive days) inhibited...
Heavy metals (HMs) are environmental pollutants that pose a threat to human health and have been accepted cause various diseases, including cancer developmental disorders. DNA replication stress has identified be associated with such diseases. However, the effect of HMs exclusively on is still not well understood. In this study, induced by thirteen was assessed using simplified in-vitro model. Two parameters, Cte/Ctc reflecting cycle threshold value alteration Ke/Kc linear phase slope...
Abstract Contradictory characteristics of elevated mutational burden and a “cold” tumor microenvironment (TME) coexist in liver kinase B1 (LKB1)–mutant non–small cell lung cancers (NSCLC). The molecular basis underlying this paradox strategies tailored to these historically difficult treat are lacking. Here, by mapping the single-cell transcriptomic landscape genetically engineered mouse models with Kras versus Kras/Lkb1-driven tumors, we detected impaired tumor-intrinsic IFNγ signaling...
Abstract Background Immune checkpoint inhibitor (ICI) therapy combined with conventional therapies is being broadly applied in non-small cell lung cancer (NSCLC) patients. However, the risk of interstitial pneumonitis (IP) following a regimen incompletely characterized. Methods A total 46,127 NSCLC patients were extracted for disproportionality analyses IP from Food and Drug Administration’s Adverse Event Reporting System (FAERS) database. 1108 who received ICI treatment at Nanfang Hospital...
Background: Studies have suggested that histone modification has a positive impact on various aspects associated with the progression of COPD. Histone deacetylase 2 (HDAC2) suppresses proinflammatory gene expression through deacetylation core histones. Objective: To investigate effect chemokines in type II alveolar epithelial cells (AEC II) rat COPD model and regulation HDAC2 by curcumin comparison corticosteroid. Materials methods: The was established cigarette smoke exposure confirmed...
We report an efficient Mo Kα x-ray source produced by interaction of femtosecond Ti: sapphire laser pulses with a solid Molybdenum target working at 1 kHz repetition rate. The generated intensity reaches to 4.7 × 1010 photons sr−1 s−1, corresponding average power 0.8 mW into 2π angle. spatial resolution this is measured be 26 lp/mm. With the high flux and characteristics, resolving in-line radiography was realized on test objects large size biological samples within merely half minute. This...
Fo Shou San (FSS) is an ancient paired-herb decoction, used in China to treat blood deficiency, stasis, stroke, and ischemic cerebral vascular disease for about one thousand years. The mechanisms associated with these properties, however, are not completely understood. Gut bacteria, gut bacterial lipopolysaccharides (LPS), alkaline phosphatase (AP), lipid peroxidation common biochemical signaling that takes place on gut-liver-brain axis. Growing evidences have revealed (LPS) enter the...
(1) Background: Antibiotic resistance in bacteria is an urgent global threat to public health. Migratory birds can acquire antibiotic-resistant and pathogenic from the environment or through contact with each other spread them over long distances. The objectives of this study were explore relationship between migratory transmission drug-resistant Escherichia coli. (2) Methods: Faeces swab samples collected for isolating E. coli on Inner Mongolia Plateau northern China 2018 2023. resistant...
Background The clinical presentation of Community-acquired pneumonia (CAP) in hospitalized patients exhibits heterogeneity. Inflammation and immune responses play significant roles CAP development. However, research on immunophenotypes is limited, with few machine learning (ML) models analyzing indicators. Methods A retrospective cohort study was conducted at Xinhua Hospital, affiliated Shanghai Jiaotong University. Patients meeting predefined criteria were included unsupervised clustering...
Abstract Background Organ-specific metastatic context has not been incorporated into the clinical practice of guiding programmed death-(ligand) 1 [PD-(L)1] blockade, due to a lack understanding its predictive versus prognostic value. We aim at delineating and then incorporating both effects metastatic-organ landscape dissect PD-(L)1 blockade efficacy in non-small cell lung cancer (NSCLC). Methods A total 2062 NSCLC patients from double-arm randomized trial (OAK), two immunotherapy trials...
Objectives: Clinical benefits of immune-checkpoint blockade (ICB) versus standard chemotherapy have been established in unselected non-small cell lung cancer (NSCLC). However, the response to ICB therapy among patients is heterogeneous clinical practice.Materials and Methods: We retrospectively assessed predicitive effect primary metastatic lesion spectrum (baseline sum longest diameters [SLD], number sites specific organ metastases) on efficacy atezolizumab over docetaxel OAK POPLAR trial...
For practical application of x-ray in-line phase contrast imaging, a high-quality image is essential for object perceptibility and quantitative imaging. The existing approach to improve quality limited by high cost physical limitations the acquisition hardware. A useful restoration algorithm based on fast wavelet transform proposed. It takes advantage degradation model extends modulation function (MTF) compensation from Fourier domain domain. modified evaluated through comparison with...
Objective:: This study aimed to compare the parametric value of T2 with and without fat suppression (FS) on mapping for evaluation extraocular muscles (EOMs) in mild thyroid-associated ophthalmopathy (TAO). Methods:: We prospectively recruited 44 consecutive patients TAO seen between May 2020 October 2022 26 healthy controls no history eye- or thyroid-related other autoimmune diseases. Patients were subdivided into active inactive groups based their clinical activity scores. The each EOM was...
Objective: This study aimed to determine the incidence of iron-deficiency anemia (IDA) complicated by splenomegaly in our hospital over past 6 years and analyze possible causes this result. Methods: is a retrospective study. In total, 668 patients with IDA who were hospitalized hematology department from 2013 2019 selected as research subjects included group, 3201 underwent outpatient physical examinations during same period control group. The incidences groups calculated, difference was...
Background Lymphoma is a common haematological malignancy with many subtypes and considerable heterogeneity. Traditional treatments include chemotherapy, radiotherapy surgery. Patients relapsed, refractory or advanced stage lymphoma have dismal prognosis. In recent years, chimeric antigen receptors (CARs) been recognized as powerful tools that redirect antigen-specific T cells independent of human lymphocyte (HLA) restriction specifically kill tumour cells. Satisfactory results CAR-based...