A5043271719- Vagus Nerve Stimulation Research
- Ultrasound and Hyperthermia Applications
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Dysphagia Assessment and Management
- Nicotinic Acetylcholine Receptors Study
- Biochemical effects in animals
- Adenosine and Purinergic Signaling
- Calpain Protease Function and Regulation
- Intracranial Aneurysms: Treatment and Complications
- Restless Legs Syndrome Research
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- EEG and Brain-Computer Interfaces
- Acute Ischemic Stroke Management
- Obstructive Sleep Apnea Research
- Hip disorders and treatments
- Ultrasound Imaging and Elastography
- Neuroscience and Neural Engineering
- Sports injuries and prevention
- Peroxisome Proliferator-Activated Receptors
- Gut microbiota and health
- Neuroscience of respiration and sleep
Dalian Medical University
2010-2024
Chongqing Medical University
2010-2024
Second Affiliated Hospital of Chongqing Medical University
2010-2024
Cumulative evidence suggests that pyroptosis, a new sort of programmed cell death, is closely related to cerebral ischemia/reperfusion (I/R) injury. Our previous studies have testified vagus nerve stimulation (VNS) was involved in many different neuroprotective and neuroplasticity pathways via α7 nicotinic acetylcholine receptor (α7nAchR), vital node the cholinergic anti-inflammatory pathway during I/R We aimed determine effects VNS through α7nAchR-mediated inhibition pyroptosis. Focal...
Transcutaneous auricular vagus nerve stimulation (ta-VNS) is a novel noninvasive treat-ment for stroke that directly stimulates the peripheral branch of nerve. There have been recent reports ta-VNS combined with conventional rehabilitation training promotes recovery neurological function patients acute stroke. However, these were small-sample-sized studies on in after percutaneous subacute and chronic phases This double-blinded randomized controlled trial involved 60 ischemic or hemorrhagic...
Backgrounds Gut microbiota plays a critical role in the onset and development of depression, but underlying molecular mechanisms are unclear. This study was conducted to explore relationships between gut host’s metabolism depression. Methods Chronic social defeat stress (CSDS) model depression established using C57BL/6 male mice. Fecal samples were collected from CSDS group control measure microbial metabolites. Meanwhile, tryptophan metabolism-related metabolites hippocampus also analyzed....
Neoangiogenesis after cerebral ischemia in mammals is insufficient to restore neurological function, illustrating the need design better strategies for improving outcomes. Our previous study has suggested that transcutaneous auricular vagus nerve stimulation (ta-VNS) induced angiogenesis and improved functions a rat model of ischemia/reperfusion (I/R) injury. However, mechanisms involved further exploration. Peroxisome proliferator-activated receptor-γ (PPAR-γ), well known as...
BACKGROUND:Environmental enrichment (EE) has a beneficial effect on some neuropsychiatric disorders. In this study, we aimed to investigate whether environmental could improve the spatial learning and memory in rats with vascular dementia (VaD) mechanism underpinning it. MATERIAL AND METHODS:Bilateral common carotid occlusion (2-vessel [2VO]) was used develop animal model of dementia. Adult male Sprague-Dawley (SD) were experiment randomly divided into 4 groups: sham group, 2VO sham+EE...
Intermittent fasting (IF), an alternative to caloric restriction, is a form of time restricted eating. IF conditioning has been suggested have neuroprotective effects and potential long-term brain health benefits. But the mechanism underlying remains unclear. The present study focused on cerebral angiogenesis effect ischemic rats. Using rat middle artery occlusion model, we assessed neurological outcomes various vascular parameters such as microvessel density (MVD), regional blood flow...
To evaluate the feasibility of focal cerebral ischemia and reperfusion (FCIR) surgery combined chronic unpredictable mild stress (CUMS) to simulate post-stroke depression (PSD) state in rats. Sprague–Dawley male rats were divided randomly into five groups: normal, sham, FCIR, CUMS, FCIR + CUMS (F/C) groups. Rats F/C groups underwent an operation. single-housed exposed for 4 weeks. group weeks after surgery. The gain bodyweight, sugar consumption ratio a sucrose preference test (SPT),...
We aim to investigate whether the higher admission fibrin degradation products (FDPs) levels are associated with parenchymal hematomas (PHs) and unfavorable outcome after intravenous thrombolysis (IVT).Consecutive patients acute ischemic stroke treated IVT were studied. The FDP level was obtained on admission. PH evaluated 24 h treatment. defined as a 90-day modified Rankin Scale >2. multivariable linear stepwise regression used assess independent factors log-transformed (lgFDP). receiver...
Background: There is no effective axon regeneration in adult mammalians. Objective: To investigate the effects of dual-acid cyclic adenosine monophosphate (db-cAMP) on regeneration, motor function recovery and RhoA signal pathway cerebral ischemia-reperfusion rats, to explore possible clinical application mechanism. Materials Methods: Middle artery model was established by nylon monofilament occlusion method 105 Sprague-Dawley (SD) rats. Semi-quantitative Western blot analysis used assess...