A5089029669- Heme Oxygenase-1 and Carbon Monoxide
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- Virus-based gene therapy research
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Pluripotent Stem Cells Research
- COVID-19 Clinical Research Studies
- Single-cell and spatial transcriptomics
- Infectious Encephalopathies and Encephalitis
- Animal Virus Infections Studies
- Cell Image Analysis Techniques
- Microtubule and mitosis dynamics
- Nanocomposite Films for Food Packaging
- Carbon Nanotubes in Composites
- Antibiotic Use and Resistance
- Muscle Physiology and Disorders
- Cerebrospinal fluid and hydrocephalus
- Immune responses and vaccinations
- Redox biology and oxidative stress
- Tissue Engineering and Regenerative Medicine
- vaccines and immunoinformatics approaches
- Anorectal Disease Treatments and Outcomes
Imperial College London
2023-2025
Harbin Medical University
2025
First Affiliated Hospital of Harbin Medical University
2025
Guangxi Center for Disease Prevention and Control
2024
Southern Medical University
2024
Nanfang Hospital
2024
Intelligent Health (United Kingdom)
2023
Nanjing Medical University
2023
Jiangsu Province Hospital
2023
Fudan University
2020-2021
The function of a cell is defined by its intrinsic characteristics and niche: the tissue microenvironment in which it dwells. Here we combine single-cell spatial transcriptomics data to discover cellular niches within eight regions human heart. We map cells microanatomical locations integrate knowledge-based unsupervised structural annotations. also profile cardiac conduction system
Background: The transcription factor BACH1 (BTB and CNC homology 1) suppressed endothelial cells (ECs) proliferation migration impaired angiogenesis in the ischemic hindlimbs of adult mice. However, role underlying mechanisms atherosclerosis remain unclear. Methods: Mouse models cell (EC)-specific-Bach1 knockout mice were used to study regulation atherogenesis mechanisms. Results: Genetic analyses revealed that coronary artery disease-associated risk variant rs2832227 was associated with...
Coronavirus disease-2019 (COVID-19) is a global pandemic with high infectivity and pathogenicity, accounting for tens of thousands deaths worldwide. Recent studies have found that the pathogen COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), shares same cell receptor angiotensin converting enzyme II (ACE2) as SARS-CoV. The pathological investigation COVID-19 showed lungs had characteristics pulmonary fibrosis. However, how SARS-CoV-2 spreads from to other organs has...
Maintenance of stem-cell identity requires proper regulation enhancer activity. Both transcription factors OCT4/SOX2/NANOG and histone methyltransferase complexes MLL/SET1 were shown to regulate activity, but how they are regulated in embryonic stem cells (ESCs) remains further studies. Here, we report a factor BACH1, which directly interacts with (OSN) maintains pluripotency mouse ESCs (mESCs). BTB domain bZIP BACH1 required for these interactions maintenance. Loss reduced the interaction...
Abstract Purpose Radiation‐induced brain injury, one of the side effects cranial radiotherapy in tumour patients, usually results durable and serious cognitive disorders. Microglia are important innate immune‐effector cells central nervous system. However, interaction between microglia neurons radiation‐induced injury remains uncharacterised. Methods Materials We established a microglia–neuron indirect co‐culture model to assess them. exposed radiation were examined for pyroptosis using...
Understanding the impact of multimorbidity on having less than 20 natural teeth is crucial for safeguarding oral health older adults with multimorbidity. This study aimed to analyze association between and in Chinese adults. The data this analysis were obtained from Longitudinal Healthy Longevity Survey (CLHLS), which covers 23 provinces, municipalities, autonomous regions throughout China. survey includes information dental (such as dentition status), a variety chronic conditions, other...
Transmissible gastroenteritis virus (TGEV) infection causes acute enteritis in swine of all ages, and especially suckling piglets. Small intestinal inflammation is considered a central event the pathogenesis TGEV infections, nuclear factor-kappa B (NF-κB) key transcription factor inflammatory response. However, it unclear whether NF-κB crucial for inducing during infection. Our results show that was activated testicular (ST) cells epithelial cell lines J2 (IPEC-J2) infected with TGEV, which...
We synthesized chitosan grafted with β-cyclodextrin (CD-g-CS) from mono-6-deoxy-6-(p-toluenesulfonyl)-β-cyclodextrin and chitosan. Two different amounts of immobilized (β-CD) on CD-g-CS (QCD: 0.643 × 103 0.6 102 μmol/g) were investigated. The results showed that the amino contents QCD = μmol/g 6.34 ± 0.072 9.41 0.055%, respectively. Agar diffusion bioassay revealed (QCD was more active against Staphylococcus xylosus Escherichia coli than μmol/g). Cell membrane integrity tests scanning...
Resistance in Gram-negative bacteria to β-lactam drugs is mediated primarily by the expression of β-lactamases, and co-dosing β-lactams with a β-lactamase inhibitor (BLI) clinically proven strategy address resistance. New β-lactamases that are not impacted existing BLIs spreading creating need for development novel broader spectrum BLIs. IID572 broad BLI diazabicyclooctane (DBO) class able restore antibacterial activity piperacillin against piperacillin/tazobactam-resistant clinical...
Plantago asiatica L. is a natural medicinal plant that has been widely used for its various pharmacological effects such as antidiarrheal, anti-inflammatory, and wound healing. This study aims to explore the antidiarrheal active ingredients of can be quality markers evaluate P. superfine powder (PSP). Molecular docking experiment was performed identify effective components L., which were further evaluated by an established mouse diarrhea model. Na + /K -ATPase creatine kinase (CK) activities...
Vascular aging is a potent driver of cardiovascular and cerebrovascular diseases. features cellular functional changes, while its molecular mechanisms the cell heterogeneity are poorly understood. This study aims to 1) explore properties aged cardiac vasculature in monkey mouse 2) demonstrate role transcription factor BACH1 regulation endothelial (EC) senescence mechanisms. Here we analyzed published single-cell RNA sequencing (scRNA-seq) data from coronary arteries aortic arches hearts. We...
Abstract COVID-19 is a global pandemic with high infectivity and pathogenicity, accounting for tens of thousands deaths worldwide. Recent studies have found that the pathogen COVID-19, SARS-CoV-2, shares same cell receptor Angiotensin converting enzyme II (ACE2) SARS-CoV. The pathological investigation death showed lung had characteristics pulmonary fibrosis. However, how SARS-CoV-2 spreads from lungs to other organs has not yet been determined. Here, we performed an unbiased evaluation...
Summary Staphylococcus xylosus ( S. )‐induced cow mastitis is an extremely serious clinical problem. However, antibiotic therapy does not successfully treat infection because these bacteria possess a strong biofilm formation ability, which significantly reduces the efficacy of treatments. In this study, we developed ceftiofur‐loaded chitosan grafted with β‐cyclodextrins (CD‐g‐CS) nanoparticles (CT‐NPs) using host–guest interaction. These positively charged improved bacterial internalization,...
Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): Leducq Foundation Background Doxorubicin (DOX) is a highly effective chemotherapeutic agent widely used for treating various types malignancies. Unfortunately, its clinical implication hampered by cardiotoxic side effects which are responsible increased mortality among cancer survivors compared to the general population. Preclinical and studies have highlighted potential mechanisms anthracycline-induced...