A5070952651- Chemotherapy-induced cardiotoxicity and mitigation
- Helicobacter pylori-related gastroenterology studies
- Tribology and Lubrication Engineering
- Gastroesophageal reflux and treatments
- Vehicle Dynamics and Control Systems
- Cardiovascular Function and Risk Factors
- Mechanical Engineering and Vibrations Research
- Gear and Bearing Dynamics Analysis
- Signaling Pathways in Disease
- Hydraulic and Pneumatic Systems
- Cancer Treatment and Pharmacology
- Liver Disease Diagnosis and Treatment
- CAR-T cell therapy research
- Eosinophilic Esophagitis
- Vibration Control and Rheological Fluids
- Brake Systems and Friction Analysis
- Mechanics and Biomechanics Studies
- Electron Spin Resonance Studies
- Soil Mechanics and Vehicle Dynamics
- Adenosine and Purinergic Signaling
- Porphyrin and Phthalocyanine Chemistry
- Cytomegalovirus and herpesvirus research
- Magnetic Bearings and Levitation Dynamics
- Adhesion, Friction, and Surface Interactions
- Immune Cell Function and Interaction
Università Cattolica del Sacro Cuore
2022-2025
University of Turin
2019-2024
University of Naples Federico II
2013-2023
University of Parma
2018-2023
University of Siena
2022
University of Padua
2022
University of Ferrara
2022
October 6 University
2022
May Institute
2022
Federico II University Hospital
2017-2020
In the first months of 2011, Internet communications were disrupted in several North African countries response to civilian protests and threats civil war. this paper we analyze episodes these disruptions two countries: Egypt Libya. Our analysis relies on multiple sources large-scale data already available academic researchers: BGP interdomain routing control plane data; unsolicited traffic unassigned address space; active macroscopic traceroute measurements; RIR delegation files; MaxMind's...
FKBP51 is a co-chaperone with isomerase activity, abundantly expressed in glioma. We previously identified spliced isoform (FKBP51s) and highlighted role for this protein the upregulation of Programmed Death Ligand 1 (PD-L1) expression melanoma. Because gliomas can express PD-L1 causing defective host anti-tumoral immunity, we investigated whether FKBP51s was glioma played regulation tumour.We used D54 U251 glioblastoma cell lines that constitutively PD-L1. measured by immunoblot, flow...
Spinal cord injury (SCI) is a severe neurological disorder associated not only with ongoing medical complications but also significant loss of mobility and participation. The introduction robotic technologies to recover lower limb function has been greatly employed in the rehabilitative practice. aim this preliminary report were evaluate efficacy, feasibility changes de-adaptations new protocol for EKSO™ exoskeleton device subjects SCI disease an impairment limbs assessed by gait analysis...
Adenosine deaminase in the peripheral lymphocytes (L-ADA) was determined 27 patients with typhoid fever and 15 normal controls. Increased values of enzymatic activity were found compared The increase prolonged not correlated to treatment. L-ADA levels could be related immune response.
This paper deals with in-curve vehicle lateral behaviour and is aimed to find out which physical characteristics affect significantly its stability. Two different analytical methods, one numerical (phase plane) the other graphical (handling diagram) are discussed. The model refers complete quadricycle, while a bicycle model. Both models take into account load transfers nonlinear Pacejka tyre–road interactions. influence of centre mass longitudinal position, tyre cornering stiffness...
Anthracyclines such as doxorubicin (Dox) are effective chemotherapies, but their use is limited by cardiac toxicity. We hypothesized that plasma proteomics in women with breast cancer could identify new mechanisms of anthracycline measured changes 1317 proteins anthracycline-treated patients ( n = 30) and replicated key findings a second cohort 31). An increase the heme-binding protein hemopexin (Hpx) 3 months after initiation was associated toxicity echocardiography. To assess functional...
Helicobacter pylori infection is a major health problem worldwide, and effective eradication of the mandatory. The efficacy recommended regimens approximately 70%. To avoid treatment failure consequent development secondary resistance(s), it important to choose most appropriate first-line regimen. This choice should also be made based on knowledge antimicrobial resistance peculiar given geographical area. We evaluated prevalence antimicrobial-resistant H strains isolated from naive patients...
This paper deals with the frictional behaviour of a tyre tread elementary volume in sliding contact road asperities. Friction is assumed to be composed two main components: adhesion and deforming hysteresis. The target, which was fixed collaboration motorsport racing team tyre-manufacturing company, provide an estimation local grip for online analyses real-time simulations evaluate predict adhesive hysteretic contributions arising at interface between road. A way approximate asperities,...
Vehicle performances, especially in motorsport, are deeply affected by tire behavior and particular compound proper working conditions. In this research activity, a series of innovations have been introduced on the Thermo Racing Tire (a physical-analytical thermal model, based Fourier’s law heat transfer applied to three-dimensional domain) order take into account all main aspects actively involved tire, as presence exhausted gases eventually impacting at rear axle inhomogeneous distribution...
The ErbB2 blocker trastuzumab improves survival in oncologic patients, but can cause cardiotoxicity. late Na+ current inhibitor ranolazine has been shown to counter experimental HF, including doxorubicin cardiotoxicity (a condition characterized by derangements redox balance), lowering the levels of reactive oxygen species (ROS). Since modulate ROS signaling, we tested whether could be blunted via redox-mediated mechanisms. Trastuzumab decreased fractional shortening and ejection fraction...
Abstract The development of therapeutic approaches based on direct cardiac reprogramming fibroblasts into induced-cardiomyocytes (iCM) has emerged as an attractive strategy to repair the injured myocardium. identification mechanisms driving lineage conversion represents a crucial step toward new and more efficient regenerative strategies. To this aim, here we show that pre-treatment with Bmi1 inhibitor PTC-209 is sufficient increase efficiency Chemical-induced Direct Cardiac Reprogramming...
5,10,15-Triphenylcorrole (1) reacts with the Vilsmeier reagent (POCl(3)/DMF) to give corresponding 3-formyl derivative 3 as major product. The regioselectivity of reaction was proven by X-ray crystallography and only traces 2-formyl isomer were observed. A more polar product is also observed this compound becomes when an excess DMF used for preparation reagent, while formation almost completely suppressed. allowed us identify fully substituted N-ethane bridged 4, formed from attack at inner...