A5029890222- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Gut microbiota and health
- Neurotransmitter Receptor Influence on Behavior
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Food Allergy and Anaphylaxis Research
- Receptor Mechanisms and Signaling
- Eicosanoids and Hypertension Pharmacology
- Probiotics and Fermented Foods
- Diet, Metabolism, and Disease
- Parkinson's Disease Mechanisms and Treatments
- Gastrointestinal motility and disorders
- Ginger and Zingiberaceae research
- Forensic Toxicology and Drug Analysis
- Inflammatory mediators and NSAID effects
- Chemical Synthesis and Analysis
- Infant Nutrition and Health
- Neuroendocrine regulation and behavior
- Synthesis and biological activity
- Helicobacter pylori-related gastroenterology studies
University of Naples Federico II
2014-2025
Federico II University Hospital
1998-2020
Human Factors (Norway)
2019
University of Pisa
2016
University of Sassari
2009
University of California, Irvine
2006
University of Georgia
2006
Naples Anesthesia & Physician Associates
2000
Regione Campania
2000
University of Cagliari
1996-1998
Palmitoylethanolamide (PEA), the naturally occurring amide of palmitic acid and ethanolamine, reduces pain inflammation through an as-yet-uncharacterized mechanism. Here, we identify nuclear receptor peroxisome proliferator-activated receptor-α (PPAR-α) as molecular target responsible for anti-inflammatory properties PEA. PEA selectively activates PPAR-α in vitro with EC<sub>50</sub> value 3.1 ± 0.4 μM induces expression mRNA when applied topically to mouse skin. In two animal models,...
Anandamide, an endogenous ligand for central cannabinoid receptors, is released from neurons on depolarization and rapidly inactivated. Anandamide inactivation not completely understood, but it may occur by transport into cells or enzymatic hydrolysis. The compound N -(4-hydroxyphenyl)arachidonylamide (AM404) was shown to inhibit high-affinity anandamide accumulation in rat astrocytes vitro, indication that this resulted carrier-mediated transport. Although AM404 did activate receptors...
Dietary intervention with extensively hydrolyzed casein formula supplemented Lactobacillus rhamnosus GG (EHCF+LGG) accelerates tolerance acquisition in infants cow's milk allergy (CMA). We examined whether this effect is attributable, at least part, to an influence on the gut microbiota. Fecal samples from healthy controls (n=20) and CMA (n=19) before after treatment EHCF (n=12) without (n=7) supplementation LGG were compared by 16S rRNA-based operational taxonomic unit clustering...
Fatty liver, oxidative stress, and mitochondrial dysfunction are key pathophysiological features of insulin resistance obesity. Butyrate, produced by fermentation in the large intestine gut microbiota, its synthetic derivative, N-(1-carbamoyl-2-phenyl-ethyl) butyramide, FBA, have been demonstrated to be protective against fatty liver. Here, hepatic mitochondria were identified as main target beneficial effect both butyrate-based compounds reverting fat accumulation diet-induced obese mice....
Severe pain remains a major area of unmet medical need. Here we report that agonists the nuclear receptor PPAR-α (peroxisome proliferator-activated receptor-α) suppress behaviors induced in mice by chemical tissue injury, nerve damage, or inflammation. The GW7647 [2-(4-(2-(1-cyclohexanebutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid], Wy-14643 [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic and palmitoylethanolamide (PEA) reduced nocifensive elicited intraplantar...
We characterized the pharmacological properties of anandamide transport inhibitor N-(4-hydroxyphenyl)-arachidonamide (AM404) in rats and investigated effects this drug on behavioral responses associated with activation dopamine D(2) family receptors. Rat brain slices accumulated [(3)H]anandamide via a high-affinity mechanism that was blocked by AM404. When administered alone vivo, AM404 caused mild slow-developing hypokinesia significant 60 min after intracerebroventricular injection...
Background : A novel class of nitric oxide‐releasing nonsteroidal anti‐inflammatory drug (NO‐NSAID) derivatives has recently been described which exert activities but produce significantly less gastrointestinal injury than the parent NSAID from they are derived. The present studies were performed to determine if a nitroxybutylester derivative naproxen was ulcerogenic tract its NSAID, and it exerted comparable analgesic properties NSAID. Methods two drugs compared in an acute gastric model,...
Fatty acid amide hydrolase (FAAH) is an intracellular serine that catalyzes the cleavage of bioactive fatty ethanolamides, such as endogenous cannabinoid agonist anandamide. Genetic deletion <i>faah</i> gene in mice elevates brain anandamide levels and amplifies antinociceptive effects this compound. Likewise, pharmacological blockade FAAH activity reduces nocifensive behavior animal models acute inflammatory pain. In present study, we investigated selective inhibitor URB597 (KDS-4103,...
Background & AimsNonalcoholic fatty liver disease (NAFLD) is the most common form of chronic disease. Insulin resistance (IR) appears to be critical in its pathogenesis. We evaluated effects sodium butyrate (butyrate) and synthetic derivative N-(1-carbamoyl-2-phenyl-ethyl) butyramide (FBA) a rat model insulin steatosis induced by high-fat diet (HFD). MethodsAfter weaning, young male Sprague-Dawley rats were divided into 4 groups receiving different diets for 6 weeks: 1. control group...
Abstract Alterations of microbiota-gut-brain axis have been invoked in the pathogenesis autism spectrum disorders (ASD). Mouse models could represent an excellent tool to understand how gut dysbiosis and related alterations may contribute autistic phenotype. In this study we paralleled microbiota (GM) profiles, behavioral characteristics, intestinal integrity immunological features colon tissues BTBR T + tf/J (BTBR) inbred mice, a well established animal model ASD. Sex differences, up date...