A5089136921- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Climate change and permafrost
- Cryospheric studies and observations
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
- Microbial bioremediation and biosurfactants
- Colorectal Cancer Surgical Treatments
- Hydrocarbon exploration and reservoir analysis
- Cancer Immunotherapy and Biomarkers
- Bacteriophages and microbial interactions
- Ovarian cancer diagnosis and treatment
- Tryptophan and brain disorders
- Inflammasome and immune disorders
- Sugarcane Cultivation and Processing
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Pediatric health and respiratory diseases
- Colorectal Cancer Treatments and Studies
- Toxic Organic Pollutants Impact
Cleveland Clinic Lerner College of Medicine
2019-2025
Case Western Reserve University
2020-2025
Cleveland Clinic
2020-2025
University School
2023-2025
Nova Southeastern University
2024
University of California, San Francisco
2024
Emory University
2024
University of Iowa
2023
Rainbow Babies & Children's Hospital
2023
University of Chicago
2015-2021
Although much work has linked the human microbiome to specific phenotypes and lifestyle variables, data from different projects have been challenging integrate extent of microbial molecular diversity in stool remains unknown. Using standardized protocols Earth Microbiome Project sample contributions over 10,000 citizen-scientists, together with an open research network, we compare specimens primarily United States, Kingdom, Australia one another environmental samples. Our results show...
Dietary intervention with extensively hydrolyzed casein formula supplemented Lactobacillus rhamnosus GG (EHCF+LGG) accelerates tolerance acquisition in infants cow's milk allergy (CMA). We examined whether this effect is attributable, at least part, to an influence on the gut microbiota. Fecal samples from healthy controls (n=20) and CMA (n=19) before after treatment EHCF (n=12) without (n=7) supplementation LGG were compared by 16S rRNA-based operational taxonomic unit clustering...
Vertebrate corpse decomposition provides an important stage in nutrient cycling most terrestrial habitats, yet microbially mediated processes are poorly understood. Here we combine deep microbial community characterization, community-level metabolic reconstruction, and soil biogeochemical assessment to understand the principles governing assembly during of mouse human corpses on different substrates. We find a suite bacterial fungal groups that contribute nitrogen reproducible network...
Patients share their microbiota with rooms and nursing staff, this shapes the microbial ecology of hospital environment.
Currently, over half of breast cancer cases are unrelated to known risk factors, highlighting the importance discovering other cancer-promoting factors. Since crosstalk between gut microbes and host immunity contributes many diseases, we hypothesized that similar interactions could occur recently described microbiome local immune responses influence pathogenesis.
Little is known about the role of genitourinary and gastrointestinal microbiota in pathogenesis male infertility. To compare taxonomic functional profiles gut, semen, urine microbiomes infertile fertile men. We prospectively enrolled 25 men with primary idiopathic infertility 12 healthy proven paternity, we collected rectal swabs, semen samples, midstream specimens, experimental controls. performed comprehensive analysis, 16S rRNA sequencing for quantitative high-resolution taxonomy, shotgun...
Objective: Gut microbial metabolism of dietary choline, a nutrient abundant in Western diet, produces trimethylamine (TMA) and the atherothrombosis- fibrosis-promoting metabolite TMA-N-oxide (TMAO). Recent clinical animal studies reveal that elevated TMAO levels are associated with heightened risks for both cardiovascular disease incident chronic kidney development. Despite this, focusing on therapeutically targeting gut microbiota-dependent production its impact preserving renal function...
Large-scale human and mechanistic mouse studies indicate a strong relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) several cardiometabolic diseases. This study aims to investigate role of TMAO in pathogenesis abdominal aortic aneurysm (AAA) target its parent microbes as potential pharmacological intervention.
The unexplained rise of young-onset CRC (yoCRC, age <50 years) is concern. Evidence suggests that microbial dysbiosis may be a contributing factor, but the tumor profile yoCRC in comparison to average-onset (aoCRC, >60) has not been fully investigated.
In this study, we show how invasive plant species drive rapid shifts in the soil environment from surrounding native communities. Each of three invaders had different but consistent effects on soils. Thus, there does not appear to be a one-size-fits-all strategy for alter grassland environments. This work represents crucial step toward understanding might able prevent or impair reestablishment by changing biotic and abiotic properties.
This paper presents the characterization of microbial community responsible for in-situ bioremediation hexachlorocyclohexane (HCH). Microbial structure and function was analyzed using 16S rRNA amplicon shotgun metagenomic sequencing methods three sets soil samples. The samples were collected from a HCH-dumpsite (450 mg HCH/g soil) comprised HCH/soil ratio 0.45, 0.0007, 0.00003, respectively. Certain bacterial; (Chromohalobacter, Marinimicrobium, Idiomarina, Salinosphaera, Halomonas,...
ABSTRACT Human-associated bacteria dominate the built environment (BE). Following decontamination of floors, toilet seats, and soap dispensers in four public restrooms, situ bacterial communities were characterized hourly, daily, weekly to determine their successional ecology. The viability cultivable bacteria, following removal dispersal agents (humans), was also assessed hourly. A late-successional community developed within 5 8 h on restroom floors showed remarkable stability over weeks...
Death due to sepsis remains a persistent threat critically ill patients confined the intensive care unit and is characterized by colonization with multi-drug-resistant healthcare-associated pathogens. Here we report that in mice caused defined four-member pathogen community isolated from patient lethal associated systemic suppression of key elements host transcriptome required for clearance decreased butyrate expression. More specifically, these pathogens directly suppress interferon...
Abstract Aims Gut microbiota and their generated metabolites impact the host vascular phenotype. The metaorganismal metabolite trimethylamine N-oxide (TMAO) is both associated with adverse clinical thromboembolic events, enhances platelet responsiveness in subjects. of TMAO on Tissue Factor (TF) vivo unknown. Here, we explore whether TMAO-enhanced thrombosis potential extends beyond effects platelets, linked to TF. We also further links between gut endothelial TF expression vivo. Methods...
Abstract Epithelial ovarian cancer (EOC) is the leading cause of gynecologic death. Despite initial responses to intervention, up 80% patient tumors recur and require additional treatment. Retrospective clinical analysis patients with indicates antibiotic use during chemotherapy treatment associated poor overall survival. Here, we assessed whether (ABX) would impact growth EOC sensitivity cisplatin. Immunocompetent or immunocompromised mice were given untreated control ABX-containing...
There is mounting evidence that microbes residing in the human intestine contribute to diverse alcohol-associated liver diseases (ALD) including most deadly form known as hepatitis (AH). However, mechanisms by which gut synergize with excessive alcohol intake promote injury are poorly understood. Furthermore, whether drugs selectively target microbial metabolism can improve ALD has never been tested. We used liquid chromatography tandem mass spectrometry quantify levels of microbe and host...
Obesity has repeatedly been linked to reorganization of the gut microbiome, yet this point obesity therapeutics have targeted exclusively toward human host. Here, we show that microbe-targeted inhibition trimethylamine N-oxide (TMAO) pathway protects mice against metabolic disturbances associated with diet-induced (DIO) or leptin deficiency (