A5001787597- Biomedical Text Mining and Ontologies
- Genetics, Bioinformatics, and Biomedical Research
- Bioinformatics and Genomic Networks
- Osteoarthritis Treatment and Mechanisms
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Colorectal Cancer Screening and Detection
- Viral-associated cancers and disorders
- Single-cell and spatial transcriptomics
- Colorectal Cancer Surgical Treatments
- Chronic Lymphocytic Leukemia Research
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Traditional Chinese Medicine Studies
- PI3K/AKT/mTOR signaling in cancer
- Gut microbiota and health
- Extracellular vesicles in disease
- Flavonoids in Medical Research
- Ubiquitin and proteasome pathways
Suzhou Kowloon Hospital
2019-2025
Cleveland Clinic
2012-2024
Cleveland Clinic Lerner College of Medicine
2018-2024
Shanghai Jiao Tong University
2024
Kowloon Hospital
2023
Nanjing University of Chinese Medicine
2021-2022
Oregon Health & Science University
2021
University of Oregon
2007-2020
Fujian University of Traditional Chinese Medicine
2015-2019
Case Western Reserve University
2016
The Reactome Knowledgebase (https://reactome.org), an Elixir core resource, provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary acquired disease processes. are annotated as ordered network transformations single consistent data model. thus functions digital archive human tool for discovering functional relationships such gene expression profiles or somatic mutation catalogs from tumor...
ZFIN, the Zebrafish Model Organism Database (http://zfin.org), is central resource for zebrafish genetic, genomic, phenotypic and developmental data. ZFIN curators manually curate integrate comprehensive data involving genes, mutants, transgenics, phenotypes, genotypes, gene expressions, morpholinos, antibodies, anatomical structures publications. Integrated views of these data, as well gathered through collaborations exchanges, are provided a wide selection web-based search forms. Among...
The unexplained rise of young-onset CRC (yoCRC, age <50 years) is concern. Evidence suggests that microbial dysbiosis may be a contributing factor, but the tumor profile yoCRC in comparison to average-onset (aoCRC, >60) has not been fully investigated.
ZFIN, the Zebrafish Model Organism Database, http://zfin.org , serves as central repository and web-based resource for zebrafish genetic, genomic, phenotypic developmental data. ZFIN manually curates comprehensive data genes, phenotypes, genotypes, gene expression, antibodies, anatomical structures publications. A wide-ranging collection of search forms tools facilitates access to integrated views these promoting analysis scientific discovery. Data represented in are derived from three...
The Zebrafish Information Network (ZFIN, http://zfin.org), the model organism database for zebrafish, provides central location curated zebrafish genetic, genomic and developmental data. Extensive data integration of mutant phenotypes, genes, expression patterns, sequences, genetic markers, morpholinos, map positions, publications community resources facilitates use as a studying gene function, development, behavior disease. Access to ZFIN is provided via web-based query forms through bulk...
The Zebrafish Information Network (ZFIN) (https://zfin.org/) is the database for model organism, zebrafish (Danio rerio). ZFIN expertly curates, organizes and provides a wide array of genetic genomic data, including genes, alleles, transgenic lines, gene expression, function, mutant phenotypes, orthology, human disease models, nomenclature reagents. New features at include increased support regions non-coding more expressive Gene Ontology annotations. has recently taken over maintenance...
The phytohormone indole-3-acetic acid (IAA) plays a vital role in plant growth and development as regulator of numerous biological processes. Its biosynthetic pathways have been studied for decades. Recent genetic vitro labeling evidence indicates that IAA Arabidopsis thaliana other plants is primarily synthesized from precursor an intermediate the tryptophan (Trp) pathway. To determine which intermediate(s) acts possible branchpoint Trp-independent biosynthesis plants, we took vivo approach...
The Zebrafish Model Organism Database (ZFIN; http://zfin.org) is the central resource for genetic and genomic data from zebrafish (Danio rerio) research. ZFIN staff curate detailed information about genes, mutants, genotypes, reporter lines, sequences, constructs, antibodies, knockdown reagents, expression patterns, phenotypes, gene product function, orthology publications. Researchers can submit mutant, transgenic, expression, phenotype directly to use Community Wiki share antibody protocol...
The Zebrafish Model Organism Database (ZFIN; http://zfin.org) is the central resource for zebrafish (Danio rerio) genetic, genomic, phenotypic and developmental data. ZFIN curators provide expert manual curation integration of comprehensive data involving genes, mutants, transgenic constructs lines, phenotypes, genotypes, gene expressions, morpholinos, TALENs, CRISPRs, antibodies, anatomical structures, models human disease publications. We integrate curated, directly submitted,...
Abstract Introduction Chronic kidney disease-mineral and bone disorder (CKD-MBD) is characterized by abnormalities, vascular calcification, some other complications. Although there are diagnostic criteria for CKD-MBD, in situations when conducting target feature examining unavailable, a need to investigate discover alternative biochemical that easy obtain. Moreover, studying the correlations between newly discovered biomarkers existing ones may provide insights into underlying molecular...
The incidence of colorectal cancer (CRC) among individuals younger than age 50 (early-onset CRC [EOCRC]) has substantially increased, and yet the etiology molecular mechanisms underlying this alarming rise remain unclear. We compared tumor-associated T-cell repertoires between EOCRC average-onset (AOCRC) to uncover potentially unique immune microenvironment-related features by onset. Our discovery cohort included 242 patients who underwent surgical resection at Cleveland Clinic from 2000...
Abstract The incidence of early-onset colorectal cancer (eoCRC) is rising, and its pathogenesis not completely understood. We hypothesized that machine learning utilizing paired tissue microbiome plasma metabolome features could uncover distinct host-microbiome associations between eoCRC average-onset CRC (aoCRC). Individuals with stages I–IV ( n = 64) were categorized as (age ≤ 50, 20) or aoCRC ≥ 60, 44). Untargeted metabolomics 16S rRNA amplicon sequencing (microbiome analysis) tumor...
ABSTRACT The aneurysmal dilation and excessive blood flow of the cephalic vein caused by relative stenosis venous arch are important challenges in maintenance arteriovenous fistulas, use adjacent vascular connection without stent protection has shown great advantages over traditional open surgery.
Psoralen (PSO), the active ingredient of Fructus Psoraleae (FP) dried ripe fruit Psoralea corylifolia L., has been commonly used in traditional Chinese medicine (TCM) for treatment osteoarthritis (OA). We found that PSO activates cartilaginous cellular functions rat chondrocytes vitro. However, effect on chondrocyte proliferation and precise mechanisms involved remain to be elucidated. investigated effects isolated from Sprague‑Dawley (SD) rats evaluated involvement Wnt/β-catenin signaling...
Dysfunctional inflammatory pathways are associated with an increased risk of cancer, including colorectal cancer. We have previously identified and enriched for a self-renewing, colon cancer stem cell (CCSC) subpopulation in primary sporadic cancers (CRC) related ulcerative colitis (UC) patients defined by the marker, aldehyde dehydrogenase (ALDH). Subsequent work demonstrated that CCSC-initiated tumors dependent on chemokine, CXCL8, known inducer tumor proliferation, angiogenesis invasion....
The Ras‑Raf‑mitogen‑activated protein kinase (MEK)1/2‑extracellular signal‑regulated (ERK)1/2 signaling pathway contributes to the release of chondral matrix‑degrading enzymes and accelerates degradation articular cartilage. Electroacupuncture (EA) treatment has been widely used for osteoarthritis (OA); however, mechanism underlying effects EA on OA remains unclear. Therefore, present study evaluated anti‑inflammatory potential mechanisms serum (EAS) tumor necrosis factor (TNF)‑α‑mediated...
// Samaneh K. Sarvestani 1, * , Steven A. Signs Veronique Lefebvre 2 Stephen Mack 3 Ying Ni 4 Andrew Morton 5 Ernest R. Chan 6 Xiaoxia Li 7 Paul Fox Angela Ting Matthew F. Kalady 8 Michael Cruise 9 Jean Ashburn 10 Jennifer Stiene 1 Wei Lai David Liska Shao Xiang and Emina H. Huang Department of Stem Cell Biology Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA Molecular Pediatrics Baylor College Houston, Texas, Genomic Pathology, Case Western Reserve...
Transcriptional activation of MYC is a hallmark many B cell lineage neoplasms. provides constitutive proliferative signal but can also initiate ARF-dependent p53 and apoptosis. The E3 ubiquitin ligase, ARF-BP1, encoded by HUWE1, modulates the activity both ARF-p53 signaling pathways, prompting us to determine if it involved in pathogenesis MYC-driven lymphomas. ARF-BP1 was expressed at high levels lines from lymphomas with either wild type or mutated not ARF-deficient cells. Downregulation...
Inflammatory bowel disease (IBD) affects one million people in the US. Ulcerative colitis (UC) is a subtype of IBD that can lead to colitis-associated cancer (CAC). In UC, rate CAC 3-5-fold greater than sporadic colorectal (CRC). The pathogenesis UC and are due aberrant interactions between host immune system microenvironment, but precise mechanisms still unknown. CAC, microenvironmental fibroblasts exhibit an activated, inflammatory phenotype contributes tumorigenesis accompanied by...
The Zebrafish Information Network (ZFIN) (https://zfin.org/) is the database for model organism, zebrafish (Danio rerio). ZFIN expertly curates, organizes, and provides a wide array of genetic genomic data, including genes, alleles, transgenic lines, gene expression, function, mutant phenotypes, orthology, human disease models, nomenclature, reagents. New features at include major updates to home page page, two most used pages ZFIN. Data mutants function continue be contributed Alliance...
Chondrocyte apoptosis triggered by endoplasmic reticulum (ER) stress plays a vital role in the pathogenesis of osteoarthritis (OA). Bushen Zhuangjin decoction (BZD) has been widely used treatment OA. However, cellular and molecular mechanisms responsible for inhibitory effects BZD on chondrocyte remain to be elucidated. In present study, we investigated ER stress-induced using vitro model Chondrocytes obtained from articular cartilage knee joints Sprague Dawley (SD) rats were detected...
Kaposi's sarcoma (KS) is a highly angiogenic and inflammatory neoplasia. The cytokine angiopoietin-2 (Ang-2) strongly expressed in KS due to sarcoma-associated herpesvirus (KSHV) infection. In the present study, we determined how Ang-2 contributes development of by using telomerase-immortalized human umbilical vein endothelial cells (TIVE) as model, which become malignantly transformed express increased levels following KSHV released from TIVE-KSHV induces tyrosine phosphorylation Tie-2...