A5002400886- Venomous Animal Envenomation and Studies
- Healthcare and Venom Research
- Gut microbiota and health
- Biochemical and Structural Characterization
- Ovarian cancer diagnosis and treatment
- Rabies epidemiology and control
- Epigenetics and DNA Methylation
- Digestive system and related health
- Platelet Disorders and Treatments
- Enzyme Production and Characterization
- Marine Invertebrate Physiology and Ecology
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Lipid Membrane Structure and Behavior
- Blood Coagulation and Thrombosis Mechanisms
- Cholesterol and Lipid Metabolism
- Antimicrobial Peptides and Activities
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Amino Acid Enzymes and Metabolism
- Protease and Inhibitor Mechanisms
- Ginseng Biological Effects and Applications
- RNA and protein synthesis mechanisms
Cleveland Clinic Lerner College of Medicine
2022-2024
Tezpur University
2014-2019
Abstract Epithelial ovarian cancer (EOC) is the leading cause of gynecologic death. Despite initial responses to intervention, up 80% patient tumors recur and require additional treatment. Retrospective clinical analysis patients with indicates antibiotic use during chemotherapy treatment associated poor overall survival. Here, we assessed whether (ABX) would impact growth EOC sensitivity cisplatin. Immunocompetent or immunocompromised mice were given untreated control ABX-containing...
The Aster-C protein (encoded by the
Elevated levels of the gut microbe-derived metabolite trimethylamine N-oxide (TMAO) are associated with cardiometabolic disease risk. However, mechanism(s) linking TMAO production to human incompletely understood. Initiation metaorganismal pathway begins when dietary choline and related metabolites converted (TMA) by bacteria. Gut TMA can then be further oxidized host flavin-containing monooxygenases generate TMAO. Previously, we showed that drugs lowering both protect mice against obesity...
Abstract This study elucidates the platelet-modulating properties of two snake venom Kunitz-type serine protease inhibitors, Rusvikunin and Rusvikunin-II, from Russell’s Viper venom, their native reconstituted complexes, synthetic custom peptides (developed platelet-binding region Rusvikunin-II) against mammalian platelet-rich plasma (PRP) washed platelets. The Rusvikunins complexes demonstrated concentration-dependent deaggregation aggregation platelets independent von Willebrand factor...
Imidazole Propionate (ImP), a gut-derived metabolite from histidine, affects insulin signaling in mice and is elevated type 2 diabetes (T2D). However, the source of histidine role gut microbiota remain unclear. We conducted an intervention study humans, comparing ImP kinetics on high-fat diet with varying levels antibiotics, assessed healthy T2D subjects supplementation. Results show that dietary metabolized to ImP, antibiotic-induced suppression reducing mice. In contrast, oral...
<div>Abstract<p>Epithelial ovarian cancer (EOC) is the leading cause of gynecologic death. Despite initial responses to intervention, up 80% patient tumors recur and require additional treatment. Retrospective clinical analysis patients with indicates antibiotic use during chemotherapy treatment associated poor overall survival. Here, we assessed whether (ABX) would impact growth EOC sensitivity cisplatin. Immunocompetent or immunocompromised mice were given untreated control...
<p>Supplemental Figures and Tables supporting manuscript.</p>
<p>Supplemental Figures and Tables supporting manuscript.</p>
<div>Abstract<p>Epithelial ovarian cancer (EOC) is the leading cause of gynecologic death. Despite initial responses to intervention, up 80% patient tumors recur and require additional treatment. Retrospective clinical analysis patients with indicates antibiotic use during chemotherapy treatment associated poor overall survival. Here, we assessed whether (ABX) would impact growth EOC sensitivity cisplatin. Immunocompetent or immunocompromised mice were given untreated control...