A5101506942- Berberine and alkaloids research
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Phytochemicals and Medicinal Plants
- Ginseng Biological Effects and Applications
- Bioactive natural compounds
- Medicinal Plants and Neuroprotection
- Alkaloids: synthesis and pharmacology
- Autophagy in Disease and Therapy
- Cell death mechanisms and regulation
- Phytochemistry and Bioactive Compounds
- Pharmacological Effects of Medicinal Plants
- Essential Oils and Antimicrobial Activity
- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- Flavonoids in Medical Research
- Plant-based Medicinal Research
- Phytoestrogen effects and research
- Chromatography in Natural Products
- Liver Disease Diagnosis and Treatment
- Curcumin's Biomedical Applications
- Sesquiterpenes and Asteraceae Studies
- Metabolomics and Mass Spectrometry Studies
- Bioactive Natural Diterpenoids Research
- Pharmacological Effects of Natural Compounds
Tianjin University of Traditional Chinese Medicine
2017-2024
Shenyang Pharmaceutical University
2013-2021
State Council of the People's Republic of China
2020
University of Hawaiʻi at Mānoa
2014
University of Hawaii System
2014
Berberine, an isoquinoline alkaloid from Coptidis Rhizoma, has been characterized as a potential anticancer drug due to its good anti-tumor effects. However, the molecular mechanisms involved in anti-gastric cancer remain poorly understood. Herein, role of berberine gastric suppression by inducing cytostatic autophagy vitro and vivo was first investigated. Results showed that induced obvious growth inhibitory effect on BGC-823 cells without toxicity human peripheral blood mononuclear cells....
Berberine, a well-known alkaloid, has been proved to possess various pharmacological activities. Previous studies demonstrated that berberine could be extensively metabolized and the metabolites also contributed its therapeutic effects. However, as for berberine’s metabolites, especially phase II pharmacokinetics excretion were rarely reported. The objective of this study was thoroughly investigate pharmacokinetic profiles nine namely, berberrubine (M1), demethyleneberberine (M2),...
Non-alcoholic fatty liver disease (NAFLD) is a major public health problem in many countries. Berberine (BBR) an effective therapeutic agent alleviating NAFLD. Berberrubine (BRB) one of the main active metabolites BBR, which shows significant anti-obesity and antihypoglycemic effects. However, whether BRB responsible for vivo effect underlying mechanism on NAFLD have not been elucidated. In this study, ability to ameliorate NAFLD, together with its molecular mechanism, was investigated. The...
Abstract Natural products have played a significant role throughout history in the prevention and treatment of numerous diseases, particularly cancers. As natural product primarily derived from various medicinal plants Withania genus, withanolides been shown several studies to exhibit potential activities cancer treatment. Consequently, understanding molecular mechanism could herald discovery new anticancer agents. Withanolides studied widely, especially last 20 years, attracted attention...
Berberine (BBR), the major isoquinoline alkaloid in Chinese herb Rhizoma coptidis, has significant lipid-lowering effect by upregulating hepatic low-density lipoprotein receptor (LDLR) expression. In a previous study, we have indicated that berberrubine (M3), metabolite of BBR vivo, displays most potential hypolipidemic effects via LDLR expression human hepatoma (HepG2) cells compared with and 3 other metabolites. Accordingly, 9 M3 analogs (A1-A9) were modified at C9 position. We aimed to...
The Aster-C protein (encoded by the
Sixteen new sesquiterpene lactones (1–16) along with 13 known analogues (17–29) were isolated from the whole plants of Centipeda minima. The structures 1–16 delineated by combination NMR spectroscopic experiments, HRESIMS, single-crystal X-ray diffraction analyses, and ECD spectra. Compounds 23–26 showed potent cytotoxicity against Hela, HCT-116, HepG2 cells IC50 values 0.8–2.6, 0.4–3.3, 1.1–2.6 μM, respectively. 8, 15, 24 exhibited significant inhibitory activity on production nitric oxide...
Poor aqueous solubility is a serious problem for most chemotherapeutics. Docetaxel (DTX), an inhibitor of microtubule depolymerization, frequently used to treat many malignancies. However, the surfactant in its commercial preparation (Taxotere) has proven problematic clinical use because it been associated with several side effects. By utilizing high DTX-loading property albumin, new formulation, DTX-incorporated albumin-lipid nanoparticles (DNPs), was prepared and evaluated. DTX bound...