A5048993991- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Vitamin D Research Studies
- Extracellular vesicles in disease
- Tryptophan and brain disorders
- Lipid metabolism and biosynthesis
- Caveolin-1 and cellular processes
- Organ and Tissue Transplantation Research
- Circadian rhythm and melatonin
- Gut microbiota and health
- Retinoids in leukemia and cellular processes
- Fibroblast Growth Factor Research
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Body Contouring and Surgery
- Medicine and Dermatology Studies History
- Hormonal Regulation and Hypertension
- Surgical Sutures and Adhesives
- Hair Growth and Disorders
- Digital Imaging in Medicine
- Mechanisms of cancer metastasis
- Adrenal Hormones and Disorders
- Hops Chemistry and Applications
- Nuclear Receptors and Signaling
The University of Texas Southwestern Medical Center
2019-2025
Cleveland Clinic Lerner College of Medicine
2020-2022
Case Western Reserve University
2009-2017
University Hospitals Cleveland Medical Center
2012
Medical College of Wisconsin
2009
Purdue University West Lafayette
2007-2008
University West
2007
To investigate the mechanism of propranolol on regression infantile hemangiomas.Propranolol has been found to be effective in treatment severe hemangiomas infancy. However, its action is as yet unknown.Cultured proliferating and involuting hemangioma endothelial cells were treated with varying concentrations for up 4 days. Analysis was performed using cell viability, migration, tubulogenesis assays, well quantitative RT-PCR flow cytometry. Western blots ELISA assays used assess protein...
Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association circulating adiponectin with healthspan lifespan. However, direct effects on promoting lifespan remain unexplored. Here, we are using an null mouse transgenic overexpression model. We directly assessed aging process found that mice display exacerbated age-related glucose lipid metabolism disorders. Moreover, significantly...
Obesity has repeatedly been linked to reorganization of the gut microbiome, yet this point obesity therapeutics have targeted exclusively toward human host. Here, we show that microbe-targeted inhibition trimethylamine N-oxide (TMAO) pathway protects mice against metabolic disturbances associated with diet-induced (DIO) or leptin deficiency (
Age-related thymic involution precedes aging of all other organs in vertebrates and initiates the process declining T cell diversity, which leads to eventual immune dysfunction. Whether FGF21, a liver-derived pro-longevity hormone that is also produced stroma, including by adipocytes, controls mechanism demise incompletely understood. Here, we demonstrate elevation FGF21 epithelial cells (TECs) adipocytes protects against aging, whereas conditional hepatic overexpression did not impact...
Background: The purpose of this study was to investigate the potential contribution environmental factors and testosterone on male alopecia. Methods: Ninety-two identical twins were recruited from 2009 2011. A comprehensive questionnaire completed followed by acquisition sputum samples for analysis standardized digital photography. Frontal, temporal, vertex hair loss assessed these photographs. Hair then correlated with survey responses levels between twin pairs. Two independent, blinded...
Abstract Plasma hyaluronan (HA) increases systemically in type 2 diabetes (T2D) and the HA synthesis inhibitor, 4-Methylumbelliferone, has been proposed to treat disease. However, is also implicated normal physiology. Therefore, we generated a Hyaluronan Synthase transgenic mouse line, driven by tet-response element promoter understand role of systemic metabolism. To our surprise, adipocyte-specific overproduction leads smaller adipocytes protects mice from high-fat-high-sucrose-diet-induced...
Abstract Dermal fibroblasts are an essential population of skin cells. They not only responsible for synthesis and remodelling the extracellular matrix dermis, but also communicate with other cells via autocrine paracrine interactions. Skin‐associated dermal adipocytes reside below reticular dermis. Strong lipolysis is observed during regression adipocytes. However, nature local intercellular crosstalk in which lipids released by affecting metabolism adjacent has yet been examined. With use...
In this study, the authors investigated potential contribution of environmental factors and testosterone levels on androgenic alopecia in women.Ninety-eight identical female twins were recruited from 2009 to 2011. Subjects asked complete a comprehensive questionnaire, provide sputum sample for analysis, pose standardized digital photography. Frontal, temporal, vertex hair loss assessed photographs using Adobe Photoshop. Hair measures then correlated with survey responses between twin pairs....
Background: The aim of this study was to compare the incidence neuroma formation and neuropathic pain following different techniques nerve ablation in a rat sural model. Methods: Rat subjected four with standardized creation 1-cm gap (n = 15 each group). These included avulsion, transection burying muscle, folding nerve, alone. Animals were killed after 3 months. Explanted nerves sectioned stained Masson trichrome S-100 stain against neural tissue. maximal cross-sectional area...
Transforming growth factor (TGF)-beta1 and fibroblast (FGF)-2 have both been shown to significant roles in the regulation of murine calvarial suture fusion. Methods decrease gene expression these cytokines their respective receptors established, but because side effects, clinical applications are limited. In this study, authors examined effect TGF-beta1-specific small interfering RNA (siRNA) on messenger (mRNA) TGF-beta1, its TGF-betaR1 TGF-betaR2 receptors, FGF-2 R1 receptor dura cells.A...
Caveolin-1 (cav1) is an important structural and signaling component of plasma membrane invaginations called caveolae abundant in adipocytes. As previously reported, adipocyte-specific ablation the cav1 gene (ad-cav1 knockout [KO] mouse) does not result elimination protein, as protein traffics to adipocytes from neighboring endothelial cells. However, this mouse a functional KO because adipocyte caveolar structures are depleted. Compared with controls, ad-cav1KO mice on high-fat diet (HFD)...
Abstract Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association circulating adiponectin with healthspan lifespan. However, direct effects on promoting lifespan remain unexplored. Here, we are using an null mouse transgenic overexpression model. We directly assessed aging process found that mice display exacerbated age-related glucose lipid metabolism disorders. Moreover,...
Understanding the biology of cranial suture fusion and precise role involved molecules implicated in process will help to identify key factors regulation fusion. Modulation these may serve as a tissue-engineering technique replace traditional surgical procedures for correction premature gene expression by RNA interference is widely used with high potential. Because there no available report calvarial organ transfection vitro, authors studied development successful nonviral delivery small...