A5087710431- Gut microbiota and health
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Head and Neck Cancer Studies
- Clostridium difficile and Clostridium perfringens research
- Colorectal Cancer Screening and Detection
- Probiotics and Fermented Foods
- Gastrointestinal motility and disorders
- Oral health in cancer treatment
- Microbial Community Ecology and Physiology
- Oral Health Pathology and Treatment
- Tryptophan and brain disorders
- Parkinson's Disease Mechanisms and Treatments
- Multiple and Secondary Primary Cancers
- Adolescent and Pediatric Healthcare
- Neurological diseases and metabolism
- Helicobacter pylori-related gastroenterology studies
- Salivary Gland Disorders and Functions
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Clinical Nutrition and Gastroenterology
- Mobile Crowdsensing and Crowdsourcing
- Immune Cell Function and Interaction
- Genomics and Phylogenetic Studies
- Misinformation and Its Impacts
Johns Hopkins University
2022-2025
Karolinska Institutet
2018-2024
Science for Life Laboratory
2021-2022
University of California, San Diego
2016-2020
Universities Space Research Association
2018
Icahn School of Medicine at Mount Sinai
2018
Center for Innovation
2018
Ames Research Center
2018
City University of New York
2018
The Graduate Center, CUNY
2018
Significance We have experimentally investigated the immunoregulatory effects of human gut microbiota in multiple sclerosis (MS). identified specific bacteria that are associated with MS and demonstrated these regulate T lymphocyte-mediated adaptive immune responses contribute to proinflammatory environment vitro vivo. Thus, our results expand knowledge microbial regulation immunity may provide a basis for development microbiome-based therapeutics autoimmune diseases.
There is mounting evidence for a connection between the gut and Parkinson's disease (PD). Dysbiosis of microbiota could explain several features PD.
Although much work has linked the human microbiome to specific phenotypes and lifestyle variables, data from different projects have been challenging integrate extent of microbial molecular diversity in stool remains unknown. Using standardized protocols Earth Microbiome Project sample contributions over 10,000 citizen-scientists, together with an open research network, we compare specimens primarily United States, Kingdom, Australia one another environmental samples. Our results show...
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant accumulation can lead to cellular dysfunctions associated neurodegenerative diseases. While genetic environmental factors influence amyloid formation, molecular triggers and/or facilitators not well defined. Growing evidence suggests that non-identical proteins may accelerate reciprocal aggregation in prion-like fashion. humans encode ~30 amyloidogenic proteins, the gut microbiome also produces...
The HLA-B27 gene is a major risk factor for clinical diseases including ankylosing spondylitis, acute anterior uveitis, reactive arthritis, and psoriatic but its mechanism of enhancement not completely understood. gut microbiome has recently been shown to influence several HLA-linked diseases. However, the role in shaping previously investigated. In this study, we characterize differences microbiota mediated by presence gene. We identified cecal Lewis rats transgenic human β2-microglobulin...
Variation in the human fecal microbiota has previously been associated with body mass index (BMI). Although obesity is a global health burden, accumulation of abdominal visceral fat specific cardio-metabolic disease risk factor. Here, we explore links between and adiposity using composition as measured by dual-energy X-ray absorptiometry large sample twins from TwinsUK cohort, comparing 16S rRNA diversity profiles six measures.We profile measures 3666 estimate their heritability, finding...
In many microbiome studies, the necessity to store samples at room temperature (i.e., remote fieldwork) and ability ship without hazardous materials that require special handling training, such as ethanol citizen science efforts), is paramount. However, although room-temperature storage for a few days has been shown not obscure physiologically relevant differences between comparison groups, there are still changes in specific bacterial taxa, notably, members of class Gammaproteobacteria ,...
To determine the effects of disease-modifying therapies, glatiramer acetate (GA) and dimethyl fumarate (DMF), on gut microbiota in patients with MS.Participants relapsing MS who were either treatment-naive or treated GA DMF recruited. Peripheral blood mononuclear cells immunophenotyped. Bacterial DNA was extracted from stool, amplicons targeting V4 region bacterial/archaeal 16S rRNA gene sequenced (Illumina MiSeq). Raw reads clustered into Operational Taxonomic Units using GreenGenes...
Microbiota has recently emerged as a critical factor associated with multiple malignancies. Nasopharyngeal carcinoma (NPC) is highly Epstein-Barr virus (EBV); the oncovirus resides and transmitted in oral cavity. However, alternation of microbiota NPC patients its potential link to EBV reactivation host cell response under simultaneous existence specific bacteria largely unknown. Here, profiles 303 controls detailed clinical information, including serum anti-virus capsid antigen (VCA) IgA...
Abstract Although much work has linked the human microbiome to specific phenotypes and lifestyle variables, data from different projects have been challenging integrate extent of microbial molecular diversity in stool remains unknown. Using standardized protocols Earth Microbiome Project sample contributions over 10,000 citizen-scientists, together with an open research network, we compare specimens primarily USA, UK, Australia one another environmental samples. Our results show unexpected...
The gut microbiome is associated with survival in colorectal cancer. Single organisms have been identified as markers of poor prognosis. However, situ imaging tumors demonstrate a polymicrobial tumor-associated community. To understand the role these communities survival, we conducted nested case-control study late-stage cancer patients undergoing resection for primary adenocarcinoma. paired tumor and adjacent normal tissue samples was profiled using 16S rRNA sequencing. We found consistent...
There is growing interest in the use of microbial-seeding interventions to mitigate impacts prenatal antibiotics, C-section, and lack breastfeeding on mother-child microbe sharing. However, relative importance maternal vaginal vs. fecal microbiota this process unclear. Analyzing 16S rRNA sequences from five US birth cohorts, we found that became more similar as pregnancy progressed, both niches influenced child's microbiota. The contribution increased when sampling occurred later gestation....