A5075977363- Multiple Sclerosis Research Studies
- Clinical Reasoning and Diagnostic Skills
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Innovations in Medical Education
- Language, Metaphor, and Cognition
- Peripheral Neuropathies and Disorders
- Neurology and Historical Studies
- Ophthalmology and Visual Health Research
- Cerebral Palsy and Movement Disorders
- Peripheral Nerve Disorders
- Reproductive System and Pregnancy
- Motor Control and Adaptation
- Sleep and related disorders
- Advanced Biosensing Techniques and Applications
- MicroRNA in disease regulation
- Medical Research and Treatments
- Autopsy Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vascular Tumors and Angiosarcomas
- Prion Diseases and Protein Misfolding
- Pregnancy and Medication Impact
- Legionella and Acanthamoeba research
- Epilepsy research and treatment
Northwestern University
2024
University of Southern California
2024
University of California, San Francisco
2018-2024
University of Pennsylvania
2020-2024
Hospital of the University of Pennsylvania
2023-2024
Office of Infectious Diseases
2023
Icahn School of Medicine at Mount Sinai
2014-2021
California University of Pennsylvania
2020
Columbia University Irving Medical Center
2020
Kaiser Permanente
2020
To address concerns regarding the effect of MS disease-modifying therapies (DMTs) on expression coronavirus 2019 (COVID-19).Review current state knowledge viral etiology COVID-19, mechanisms injury by SARS-CoV-2 infection, and individual DMTs risk infection COVID-19 disease expression.Although data are limited, do not obviously increase acquiring symptomatic infection. The severe morbidity mortality appear to be largely consequence an overly robust immune response rather than unchecked...
To determine the effects of disease-modifying therapies, glatiramer acetate (GA) and dimethyl fumarate (DMF), on gut microbiota in patients with MS.Participants relapsing MS who were either treatment-naive or treated GA DMF recruited. Peripheral blood mononuclear cells immunophenotyped. Bacterial DNA was extracted from stool, amplicons targeting V4 region bacterial/archaeal 16S rRNA gene sequenced (Illumina MiSeq). Raw reads clustered into Operational Taxonomic Units using GreenGenes...
Individuals with multiple sclerosis (MS) frequently present depression and anxiety, as well cognitive impairment, challenging clinicians to disentangle interrelationships among these symptoms.To identify functions associated anxiety in MS.Mood cognition were measured 185 recently diagnosed patients (Reserve Against Disability Early Multiple Sclerosis (RADIEMS) cohort), an independent validation sample (MEM CONNECT cohort, n = 70). Partial correlations evaluated relationships of controlling...
Background: Persons with multiple sclerosis (MS) commonly report word-finding difficulty clinically, yet this language deficit remains underexplored. Objective: To investigate the prevalence and nature of in persons early MS on three levels: patient report, cognitive substrates, neuroimaging. Methods: Two samples patients ( n = 185 55; ⩽5 years diagnosed) healthy controls 50) reported frequency/severity deficits underwent objective assessment tasks rapid automatized naming (RAN), measuring...
To test the hypothesis that higher-challenge gait and balance tasks are more sensitive than traditional metrics to subtle patient-reported dysfunction future fall risk in early multiple sclerosis (MS).Persons with MS (n = 185; ≤5 years diagnosed) reported function (MS Walking Scale) underwent disability (Expanded Disability Status Scale [EDSS], Timed 25 Foot Walk). Patients healthy controls 50) completed clinically feasible challenge of endurance (2-Minute Walk Test), standing (NIH Toolbox),...
Abstract Objective Postpartum, patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) have increased risk for disease activity. Anti‐CD20 IgG1 monoclonal antibodies (mAb) are increasingly used as disease‐modifying therapies (DMTs). Patients may wish to both breastfeed resume DMT postpartum. This study aimed determine the transfer of anti‐CD20 mAbs, ocrelizumab, rituximab (OCR/RTX), into mature breastmilk describe maternal infant outcomes. Methods Fifty‐seven...
Background: Psychologically resilient persons persist despite obstacles and bounce back after adversity, leading to better outcomes in non-neurologic populations. It is unknown whether psychological resilience relates objective functional multiple sclerosis (MS). Objective: To determine explains differential cognitive motor functioning with early MS. Methods: Psychological was assessed 185 patients MS 50 matched healthy controls the Connors-Davidson Resilience Scale (CDRS-10). Subjects...
Racial disparities exist in both neurologic and obstetric populations, underscoring the importance of evaluating pregnancy outcomes diverse women with multiple sclerosis (MS). The objective this multicenter retrospective study was to compare care between Black Hispanic (underrepresented) White MS.
Fumarates are effective immunomodulators in multiple sclerosis but their mechanism of action remains elusive. Ntranos et al. show that the immunomodulatory effect fumarates is due to epigenetic regulation brain-homing T cells. Treatment with leads hypermethylation microRNA-21, preventing its upregulation encephalitogenic T-helper and T-cytotoxic
Despite significant interest in diet by the MS community, research on this topic is limited; there are no published studies evaluating associations between and neuroimaging MS.We utilized baseline data from RADIEMS cohort of early (diagnosed <5.0 years, n=180). Participants underwent brain MRIs to derive normalized total gray thalamic volumes, T2 lesion volume, white matter microstructural integrity normal appearing (NAWM). completed food frequency questionnaires (FFQ) which we calculated...
ABSTRACT Multiple sclerosis (MS) is an immune-mediated neurological disorder that affects one million people in the United States. Up to 50% of with MS experience depression, yet mechanisms depression remain under-investigated. Studies medically healthy participants have described associations between white matter variability and depressive symptoms, but frequently exclude medical comorbidities thus cannot be extrapolated intracranial diseases. White lesions are a key pathologic feature...
Persons with multiple sclerosis (MS) and depression symptoms report real-world cognitive difficulties that may be missed by laboratory tests.
Abstract Objective Sleep‐dependent memory processing occurs in animals including humans, and disturbed sleep negatively affects memory. Sleep disturbance dysfunction are common multiple sclerosis (MS), but little is known about the contributions of to MS. We investigated whether subjective linked worse early MS independently potential confounders. Methods Persons with ( n = 185; ≤5.0 years diagnosed) demographically matched healthy controls 50) completed four tests derive a composite,...
The objective of this study was to report on the development neuroinvasive West Nile virus (WNV) infection in context anti-CD20 monotherapy for multiple sclerosis (MS).
When persons with multiple sclerosis (MS) report memory decline but objective performance is normal, there a bias toward believing test results.Investigate whether subjective or more related to hippocampal and subfield volumes in early MS.Persons MS (n = 185; ⩽5.0 years diagnosed) completed questionnaire; an composite was derived from four tests. Total were high-resolution 3.0 T magnetic resonance images (MRIs). Partial correlations assessed links between both memory, controlling for age,...
Objectives: We report a case of primary neurolymphomatosis (NL) with unusual presentation and excellent treatment response. Methods: Chart review. Results: A 64-year-old woman presented 2 months progressive pain, weakness, numbness in her right leg. Nerve conduction study/electromyogram suggested lumbosacral radiculoplexus neuropathy associated acute peroneal at the fibular head. L/S spine leg magnetic resonance imaging showed thickening contrast enhancement S1 nerve root distal sciatic,...
To enhance residency education by implementing the 6 principles of adult learning theory (ALT) in a large academic neurology program.We implemented set curricular interventions aimed at Resident Education through Adult Learning Neurology (REAL Neurology), large, program. Interventions included didactic reform, increasing resident-as-teacher activities, and enhancing residents' interaction. The primary outcome was change mean Residency In-service Training Examination (RITE) percentile between...
Total brain white matter lesion (WML) volume is the most widely established magnetic resonance imaging (MRI) outcome measure in studies of multiple sclerosis (MS). To estimate WML volume, there are a number automatic segmentation methods available, yet manual delineation remains gold standard approach. Automatic approaches often yield probability map to which threshold applied create masks. Unfortunately, few systematically determine employed; many use manually selected threshold, thus...
To characterize evolving management of neuromyelitis optica spectrum disorder (NMOSD) in clinical practice.
<h3>Objective</h3> To describe cases presented by junior neurology residents and to evaluate resident diagnostic patterns help address individual systemic educational needs. <h3>Methods</h3> For 6 academic years, details of all morning report assessed were logged, including the resident9s independent initial impression. Cases later revisited at subsequent reports "close loop" on a final diagnosis. We conducted retrospective review quantify case demographics determine accuracy based...