A5031163710- Aortic aneurysm repair treatments
- COVID-19 Clinical Research Studies
- Aortic Disease and Treatment Approaches
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Tryptophan and brain disorders
- Cardiac Arrest and Resuscitation
- Cerebrovascular and Carotid Artery Diseases
- Eicosanoids and Hypertension Pharmacology
- Platelet Disorders and Treatments
- Inflammatory mediators and NSAID effects
- Extracellular vesicles in disease
- Lymphatic System and Diseases
- Blood properties and coagulation
- Infectious Aortic and Vascular Conditions
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammasome and immune disorders
- Renal and Vascular Pathologies
- Gut microbiota and health
- Acute Myocardial Infarction Research
- Acute Ischemic Stroke Management
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Cleveland Clinic
2020-2024
Sorbonne Paris Cité
2023
Université Paris Cité
2023
Inserm
2023
Washington University in St. Louis
2023
Cleveland Clinic Lerner College of Medicine
2021-2022
Center for Vascular Biology Research
2021
Michigan Medicine
2020
Yale New Haven Hospital
2015-2016
Yale University
2015-2016
Rationale: Coronavirus disease 2019 (COVID-19) is characterized by increased incidence of microthrombosis with hyperactive platelets sporadically containing viral RNA. It unclear if SARS-CoV-2 (severe acute respiratory syndrome, corona virus-2) directly alters platelet activation or these changes are a reaction to infection-mediated global inflammatory alterations. Importantly, the direct effect on has yet be studied. Objective: To characterize SARS-CoV-2–platelet interactions using in vitro...
Large-scale human and mechanistic mouse studies indicate a strong relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) several cardiometabolic diseases. This study aims to investigate role of TMAO in pathogenesis abdominal aortic aneurysm (AAA) target its parent microbes as potential pharmacological intervention.
As blood transitions from steady laminar flow (S-flow) in healthy arteries to disturbed (D-flow) aneurysmal arteries, platelets are subjected external forces. Biomechanical platelet activation is incompletely understood and a potential mechanism behind antiplatelet medication resistance. Although it has been demonstrated that drugs suppress the growth of abdominal aortic aneurysms (AAA) patients, we found certain degree reactivity persisted spite aspirin therapy, urging us consider...
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is an ongoing viral pandemic marked increased risk of thrombotic events. However, the role platelets in elevated observed COVID-19 and utility antiplatelet agents attenuating thrombosis unknown. We aimed to determine if effect aspirin may mitigate myocardial infarction, cerebrovascular accident, venous thromboembolism COVID-19. evaluated 22,072 symptomatic patients tested for Propensity-matched analyses were performed treatment with or...
Coronavirus disease-2019 (COVID-19) caused by SARS-CoV-2 is an ongoing viral pandemic marked increased risk of thrombotic events. However, the role platelets in elevated observed COVID-19 and utility anti-platelet agents attenuating thrombosis unknown. We aimed to determine if human express known receptor-protease axis on their cell surface assess whether effect aspirin may mitigate myocardial infarction (MI), cerebrovascular accident (CVA), venous thromboembolism (VTE) COVID-19. Expression...
The platelet phenotype in certain patients and clinical contexts may differ from healthy conditions. We evaluated activation through specific receptors men women, comparing this to presenting with ST-segment-elevation myocardial infarction non-ST-segment-elevation infarction. Approach Results: identified independent predictors of a murine MI model further explored these findings. Platelets women female mice are more reactive PARs (protease-activated receptors) compared platelets male mice....
Importance Preclinical studies suggest a potential role for aspirin in slowing abdominal aortic aneurysm (AAA) progression and preventing rupture. Evidence on the clinical benefit of AAA from human is lacking. Objective To investigate association use with long-term outcomes patients AAA. Design, Setting, Participants This was retrospective, single-center cohort study. Adult at least 2 available vascular ultrasounds Cleveland Clinic were included, history repair, dissection, or rupture...
Background: Patients with lymphedema and lipedema share physical exam findings that may lead to misdiagnosis. Poor mobility is common in patients obesity lipedema. This constitute a risk factor for venous thromboembolism (VTE). Our objective was evaluate the association of VTE obese Methods: The National Inpatient Sample (NIS) searched from 2016 2020 identify hospital admissions female were analyzed context presence or absence while adjusting complex cluster sampling techniques. Predictors...
Abstract Drosophila CREB-binding protein (dCBP) is a very large multidomain protein, which belongs to the CBP/p300 family of proteins that were first identified by their ability bind CREB transcription factor and adenoviral E1. Since then CBP has been shown >100 additional functions in multitude different developmental contexts. Among other activities, known influence development remodeling chromatin, serving as transcriptional coactivator, interacting with terminal members several...
Patients infected with SARS-CoV-2 often develop venous and arterial thrombosis. The high patient mortality is partly attributed to thrombotic events. An emerging trend the presence of immunological phenomena including antiphospholipid antibodies which may promote mechanism for these observations not clear though many patients thrombocytopenia.We describe a pneumonitis who presented intermediate risk pulmonary embolism (PE). Careful attention his daily platelet count suggested possibility...
ABSTRACT A common feature in patients with abdominal aortic aneurysms (AAA) is the formation of a nonocclusive intraluminal thrombus (ILT) regions dilation. Platelets are known to maintain hemostasis and propagate thrombosis through several redundant activation mechanisms, yet role platelet pathogenesis AAA associated ILT still poorly understood. Thus, we sought investigate how impacts AAA. Using RNA-sequencing, identify that platelet-associated transcripts significantly enriched compared...
In-hospital cardiac arrests (IHCA) occur commonly and are associated with poor survival variable outcomes. This study aimed to directly survey IHCA responders understand their perceptions of resuscitation care.As part a quality improvement initiative, we surveyed participating providers IHCAs at our institution from Jan 2014 May 2016. The included unstructured free text feedback, which was the focus this study. We systematically coded organized identifiable latent themes using thematic...
There is a paucity of data on how race affects the clinical presentation and short-term outcome among hospitalized patients with SARS-CoV-2, 2019 coronavirus (COVID-19). Hospitalized ≥ 18 years, testing positive for COVID-19 from March 13, 2020 to May in United States (U.S.) integrated healthcare system multiple facilities two states were evaluated. We documented racial differences presentation, disposition, in-hospital outcomes COIVD-19. Multivariable regression analysis was utilized...