A5025216603- Leptospirosis research and findings
- Systemic Lupus Erythematosus Research
- Blood disorders and treatments
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Extracellular vesicles in disease
- Genetics, Bioinformatics, and Biomedical Research
- Advanced Proteomics Techniques and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Platelet Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Blood Coagulation and Thrombosis Mechanisms
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vector-Borne Animal Diseases
- Renal Diseases and Glomerulopathies
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Venous Thromboembolism Diagnosis and Management
- Neutropenia and Cancer Infections
- Vascular Anomalies and Treatments
- Cell Adhesion Molecules Research
Cleveland Clinic
2014-2025
University of Tennessee Health Science Center
2021-2025
The University of Texas Health Science Center at Tyler
2020-2024
University of Delhi
2014-2023
Indian Institute of Technology Jodhpur
2023
Vanderbilt University Medical Center
2022
Cleveland Clinic Lerner College of Medicine
2010-2021
Visva-Bharati University
2021
Case Western Reserve University
2010-2018
South Asian University
2014-2018
Bacterial pathogens are associated with severe infections (e.g. sepsis) and exacerbation of debilitating conditions such as chronic obstructive pulmonary disease (COPD). The interactions bacterial macrophages, a key component innate immunity host defense, not clearly understood continue to be intensively studied. Having previously demonstrated role Wnt5A signaling in phagocytosis, we proceeded decipher the connection infection by pathogenic bacteria, namely Pseudomonas aeruginosa...
Lung carcinoma is the leading cause of cancer-related death worldwide, and among this cancer, non-small cell lung (NSCLC) comprises majority cases. Furthermore, recurrence metastasis NSCLC correlate well with CD133+ve tumor cells, a small population cells that have been designated as cancer stem (CSC). We demonstrated for first time high expression D2 dopamine (DA) receptors in adenocarcinoma cells. Also, activation DA these significantly inhibited their proliferation, clonogenic ability,...
Leptospirosis is an emerging infectious disease. Recently, canine and human leptospirosis outbreaks were reported in California New York, respectively. In this study we evaluated the role that cell death processes play inflammatory response to Leptospira. Groups of male C3H/HeJ mice infected with pathogenic L. interrogans non-pathogenic biflexa for 24 72 hours; characterized apoptosis necroptosis by flowcytometry spleen cells further assessed expression biomarkers western blot. We found...
Abstract Mice are slowly being accepted as alternative models for investigation of leptospiral infection. The strain most used to analyse sublethal disease (C3H-HeJ) expresses a tlr4 gene in its immune cells that is hyporesponsive LPS and thus the model deemed immunocompromised. To help resolve this valid scientific concern we did study which compared infection with Leptospira interrogans serovar Copenhageni Fiocruz mice expressing fully competent (C3H-HeN, C57BL6) versus (C3H- HeJ) over...
Maternal antibody transfer provides passive immunity to offspring; however, the efficacy and duration of this protection depends on maternal levels efficiency. We investigated whether oral vaccination Peromyscus leucopus dams with recombinant OspA-expressing E. coli could induce anti-OspA antibodies protect pups from Borrelia burgdorferi challenge. Dams were vaccinated for different durations: (i) until breeding, (ii) birth pups, or (iii) 2 weeks old. Pups challenged Ixodes scapularis...
Abstract Src homology region 2 domain-containing phosphatase 1 (SHP-1) has been implicated as a potential cancer therapeutic target by its negative regulation of immune cell activation and the activity SHP-1 inhibitor sodium stibogluconate that induced IFN-γ+ cells for anti-tumor action. To develop more potent SHP-1-targeted anti-cancer agents, inhibitory leads were identified from library 34,000 drug-like compounds. Among active at low nM recombinant SHP-1, tyrosine inhibitor-1 (TPI-1)...
Glioblastoma multiforme (GBM) is one of the most lethal forms cancer, with a survival rate only 13% to 27% within 2 years diagnosis despite optimal medical treatment. We hypothesize that presence unique IL-13Rα2 decoy receptor prevents GBM apoptosis. This has high affinity for interleukin-13 (IL-13), binds cytokine, and competitively inhibits intracellular signaling cascade initiated by IL-13. In cells lacking receptor, IL-13 initiates production 15-lipoxygenase-1 (15-LOX-1), which been...
Monoamine oxidase A (MAO-A) is a mitochondrial flavoenzyme implicated in the pathogenesis of atherosclerosis and inflammation also many neurological disorders. MAO-A has been reported as potential therapeutic target prostate cancer. However, regulatory mechanisms controlling cytokine-induced expression immune or cancer cells remain to be identified. Here, we show that co-induced with 15-lipoxygenase (15-LO) interleukin 13 (IL-13)-activated primary human monocytes A549 non-small cell lung...
Strategies for disease control are necessary to reduce incidence of Lyme Disease (LD) including development safe vaccines human use. Parainfluenza virus 5 (PIV5) vector has an excellent safety record in animals and PIV5-vectored currently under clinical development. We constructed LD vaccine candidates expressing OspA from B. burgdorferi (OspA
Leptospirosis is a neglected zoonotic disease caused by pathogenic Leptospira spp., affecting an estimated of one million people annually and resulting in approximately 60,000 fatalities. The can lead to hepatic, renal, pulmonary dysfunctions may contribute the development chronic kidney disease. Complement System plays crucial role eliminating bacteria generating opsonins, anaphylotoxins, that degranulate mastocytes basophils, attract immune cells infection site, among other important...
Previous studies demonstrated that Leptospira biflexa , a saprophytic species, triggers innate immune responses in the host during early infection. This raised question of whether these could suppress subsequent challenge with pathogenic . We inoculated C3H/HeJ mice single or double dose L. before serovar, interrogans serovar Copenhageni FioCruz (LIC). Pre-challenge exposure to did not prevent LIC dissemination and colonization kidney. However, it rescued weight loss mouse survival thereby...
The exact global impact of leptospirosis is unknown due to inadequate surveillance systems in place most low-income countries. In this study, we analyzed the differences mouse inflammatory signatures involved pathogenic versus non-pathogenic Leptospira recognition at 24h and 72h post infection. Injection C3H-HeJ mice with L. biflexa increased circulation a few chemokines (5/21, 24%) without secretion cytokines blood that resulted engagement resident macrophages, dendritic cells, neutrophils...
Abstract Primary gut involvement by Aspergillus is an exceedingly rare and often a fatal complication of intensive chemotherapy in patients with acute leukaemia. We report 46‐yr‐old patient granulocytic sarcoma the testis. He received myeloid leukaemia type treatment ADE (Cytosine Arabinoside, Daunorubicin Etoposide). While neutropenic he presented pyrexia, abdominal pain massive distention. was treated intravenous antibiotics antifungals according to our usual institutional protocol without...
Analysis of
Lyme disease is rapidly spreading from its usual endemic areas in the Northeast, Midwest, and Midatlantic states into neighboring areas, which could be due to changing climate patterns. Our study shows that unfed I. scapularis nymphal ticks kept under optimal environmental conditions laboratory survived for a year while exhibiting aggressive host-seeking behavior, they maintained B. burgdorferi infection prevalence was sufficient infect naive reservoir hosts after tick challenge.
Abstract Drug resistance is a major obstacle in cancer treatments and diminishes the clinical efficacy of biological, cytotoxic, or targeted therapeutics. Being an antiapoptotic mediator chemoresistance breast lung cells, MKP1 phosphatase might be for overcoming improving therapeutic efficacy. In this work, tyrosine inhibitor-3 (TPI-3) was identified as novel small molecule inhibitor capable sensitizing tumors to bio- chemotherapeutics mice tolerated oral agent. Effective against recombinant...