A5013355417- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood Coagulation and Thrombosis Mechanisms
- Vitamin K Research Studies
- Hemophilia Treatment and Research
- Connexins and lens biology
- Mast cells and histamine
- Platelet Disorders and Treatments
- Autoimmune Bullous Skin Diseases
- Protease and Inhibitor Mechanisms
- Urticaria and Related Conditions
- Natural product bioactivities and synthesis
- Venous Thromboembolism Diagnosis and Management
- Intraocular Surgery and Lenses
- Ion channel regulation and function
- Vanadium and Halogenation Chemistry
- Hemoglobinopathies and Related Disorders
- Blood donation and transfusion practices
- Protein Kinase Regulation and GTPase Signaling
- Peptidase Inhibition and Analysis
- Enzyme function and inhibition
- Herpesvirus Infections and Treatments
- Hormonal Regulation and Hypertension
- Iron Metabolism and Disorders
- Computational Drug Discovery Methods
- Trace Elements in Health
Vanderbilt University Medical Center
2017-2025
UNSW Sydney
2023
Vanderbilt University
2008-2021
Oregon Health & Science University
2008
VA Tennessee Valley Healthcare System
2008
National Eye Institute
2000-2003
Georgetown University
2003
Georgetown University Medical Center
2003
National Institutes of Health
2000-2002
Temple University
2001
Sepsis, a systemic inflammatory response to infection, is often accompanied by abnormalities of blood coagulation. Prior work with mouse model sepsis induced cecal ligation and puncture (CLP) suggested that the protease factor XIa contributed disseminated intravascular coagulation (DIC) cytokine during sepsis. We investigated importance XI responses first 24 hours after CLP. Compared wild type littermates, XI-deficient (FXI-/-) mice had survival advantage CLP, smaller increases in plasma...
Anticoagulation is a rational approach to the treatment of sepsis-associated consumptive coagulopathy, but its application limited because risk excessive bleeding. Factor XI (FXI) contributes substantially pathological blood coagulation (thrombosis), whereas it only modestly normal hemostasis. We found that FXI-deficient mice have reduced coagulopathy and increased survival relative FXI-expressing wild-type during cecal ligation puncture-induced acute peritonitis/sepsis. This finding...
In plasma, the zymogens factor XII (FXII) and prekallikrein reciprocally convert each other to proteases FXIIa plasma kallikrein (PKa). PKa cleaves high-molecular-weight kininogen (HK) release bradykinin, which contributes regulation of blood vessel tone permeability. Plasma FXII is normally in a "closed" conformation that limits activation by PKa. When binds surface during contact it assumes an "open" increases rate Mutations disrupt closed have been identified patients with conditions...
Hepatitis delta virus (HDV) produces two essential forms of the sole viral protein from same open reading frame by using host RNA editing activity at amber/W site in antigenomic RNA. The roles these forms, HDAg-S and HDAg-L, are opposed. is required for replication, whereas which produced as a result editing, inhibits replication virion packaging. Both rate amount important because excessive will inhibit insufficient reduce secretion. Here we show that HDV genotype III, associated with...