A5003359128- Vector-borne infectious diseases
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Leptospirosis research and findings
- Vector-Borne Animal Diseases
University of Tennessee Health Science Center
2025
Raigmore Hospital
2022
University of Liverpool
2019
Maternal antibody transfer provides passive immunity to offspring; however, the efficacy and duration of this protection depends on maternal levels efficiency. We investigated whether oral vaccination Peromyscus leucopus dams with recombinant OspA-expressing E. coli could induce anti-OspA antibodies protect pups from Borrelia burgdorferi challenge. Dams were vaccinated for different durations: (i) until breeding, (ii) birth pups, or (iii) 2 weeks old. Pups challenged Ixodes scapularis...
Testing for IgM antibodies to Borrelia burgdorferi in Scottish patients with suspected Lyme borreliosis was introduced 2018 supplement the IgG testing already situ. Results from 2020 were assessed alongside available clinical data evaluate utility of serum. An estimated false positive rate 25.5% observed immunoblot vs 80.1% chemiluminescent immunoassay (CLIA). can aid earlier diagnoses if used within a selective two-tier protocol: only acute onset symptoms should be tested CLIA but...
Lyme disease (LD) is a multisystem infection caused by tick-borne spirochaetes of the Borrelia burgdorferii sensu lato group. UK and US laboratory diagnosis LD involves two-tier serological approach. The negative predictive value test has been challenged, particularly in early stage LD. There considerable interest, therefore, development improved diagnostic tests. main aim project to identify new markers that could form basis for A mass spectrometry biomarker discovery study was undertaken...