A5041376881- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Vitamin C and Antioxidants Research
- Nutrition, Genetics, and Disease
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroendocrine regulation and behavior
- Pharmacological Effects and Toxicity Studies
- Pharmacological Effects of Natural Compounds
- Natural Antidiabetic Agents Studies
- Drug Transport and Resistance Mechanisms
- Neuroscience of respiration and sleep
- Pharmacological Receptor Mechanisms and Effects
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Berberine and alkaloids research
- Memory and Neural Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Prenatal Substance Exposure Effects
- Plant-based Medicinal Research
- Biochemical effects in animals
Sapienza University of Rome
2013-2022
Marymount University
2011
Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele
2008
Population Council
1993
Rockefeller University
1993
Cocaine exposure triggers molecular events that lead to long-lasting changes in brain structure and function. These can the development of persistent robust behavioral adaptations characterize addiction. Recent evidence suggests regulation transcription via chromatin modification, such as histone acetylation, has an important role addictive behavior. Histone acetylation is regulated by acetyltransferases (HATs), which acetylate histones promote transcription, deacetylases (HDACs), remove...
Background and Purpose Autism spectrum disorder (ASD) is more commonly diagnosed in males than females. Prenatal exposure to the antiepileptic drug valproic acid (VPA) an environmental risk factor of ASD. Male rats prenatally exposed VPA show socio‐emotional autistic‐like dysfunctions that have been related changes activity endocannabinoid anandamide. Here, we investigated if prenatal induced sex‐specific autistic endophenotypes involving anandamide signalling. Experimental Approach We...
The three currently available male contraceptive approaches are 1) the barrier method such as condom, 2) hormonal methods by disrupting pituitary-testicular axis so to impair spermatogenesis, and 3) immunological preparing vaccines against male-specific antigens. We hereby describe an alternative approach in which attachments of developing germ cells onto seminiferous epithelium disrupted, thereby inducing their premature release into tubular lumen. This turn leads infertility. A panel...
Variations in environmental aversiveness influence emotional memory processes rats. We have previously shown that cannabinoid effects on are dependent the stress level at time of training as well context. Here, we investigated whether hippocampal endocannabinoid system modulates retrieval depending training-associated arousal level. Male adult Sprague Dawley rats were trained a water maze spatial task two different temperatures (19°C and 25°C) to elicit either higher or lower levels,...
The endocannabinoid system shows functional activity from early stages of brain development: it plays an important role in fundamental developmental processes such as cell proliferation, migration and differentiation, thus shaping organization during pre- postnatal life. Cannabis sativa preparations are among the illicit drugs most commonly used by young people, including pregnant women. developing can be therefore exposed to cannabis two critical periods: first, offspring cannabis-using...
Background Propofol is associated with postoperative mood alterations and induces a higher incidence of dreaming compared other general anesthetics. These effects might be mediated by propofol's inhibitory action on fatty acid amide hydrolase, the enzyme that degrades endocannabinoid anandamide. Because propofol also traumatic memories from perioperative awareness intensive care unit treatment system involved in regulating memory consolidation emotional experiences, authors investigated...
The new-released Diagnostic and Statistical Manual of Mental Disorders (DSM-5) defines post-traumatic stress disorder (PTSD) as a "trauma stressor-related disorder". PTSD pathogenesis relies on paradoxical changes emotional memory processing induced by the trauma exposure associated with dysfunction. Several animal models have been validated are currently used. Each one mimics particular subset emphasis, mainly driven past classification in DSM-4, features. In view recent update DSM-5, our...