A5002742138- Pain Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Ion Channels and Receptors
- Pharmacological Receptor Mechanisms and Effects
- Neurotransmitter Receptor Influence on Behavior
- Botulinum Toxin and Related Neurological Disorders
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- Neuroscience of respiration and sleep
- Amino Acid Enzymes and Metabolism
- Pharmacological Effects of Natural Compounds
- Inflammatory mediators and NSAID effects
- Forensic Toxicology and Drug Analysis
- Diet and metabolism studies
- Nerve injury and regeneration
- Gut microbiota and health
- Diet, Metabolism, and Disease
- Receptor Mechanisms and Signaling
- Eicosanoids and Hypertension Pharmacology
- Estrogen and related hormone effects
- Pancreatic function and diabetes
- Biochemical effects in animals
University of Campania "Luigi Vanvitelli"
2016-2025
Yale University
2020
Harvard University
2020
Rockefeller University
2020
National Institutes of Health
2020
University of Naples Federico II
2010-2019
National Research Council
2017
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2016
Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
2015
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi
2012
Fatty liver, oxidative stress, and mitochondrial dysfunction are key pathophysiological features of insulin resistance obesity. Butyrate, produced by fermentation in the large intestine gut microbiota, its synthetic derivative, N-(1-carbamoyl-2-phenyl-ethyl) butyramide, FBA, have been demonstrated to be protective against fatty liver. Here, hepatic mitochondria were identified as main target beneficial effect both butyrate-based compounds reverting fat accumulation diet-induced obese mice....
Microglia respond rapidly to injury, increasing their synthesis and release of inflammatory mediators, many which contribute the maintenance persistent pain following CNS or PNS injury. We have recently shown that lysosomal cysteine protease Cathepsin S (CatS) expressed by spinal microglia is vital for full expression neuropathic pain. Here we evaluated mechanisms CatS occurs from primary in culture. Stimulation with lipopolysaccharide (LPS) adenosine tri-phosphate (ATP) alone was...
Enhanced supraspinal glutamate levels following nerve injury are associated with pathophysiological mechanisms responsible for neuropathic pain. Chronic pain can interfere specific brain areas involved in glutamate-dependent neuropsychological processes, such as cognition, memory, and decision-making. The medial prefrontal cortex (mPFC) is thought to play a critical role pain-related depression anxiety, which frequent co-morbidities of chronic Using an animal model spared (SNI) the sciatic...
The endogenous fatty acid amide palmitoylethanolamide (PEA) has been shown to exert anti-inflammatory actions mainly through inhibition of the release pro-inflammatory molecules from mast cells, monocytes and macrophages. Indirect activation endocannabinoid (eCB) system is among several mechanisms action that have proposed underlie different effects PEA in vivo. In this study, we used cultured rat microglia human macrophages evaluate whether affects eCB signaling. was found increase CB2 mRNA...
Recent evidence points to the gut microbiota as a regulator of brain and behavior, although it remains be determined if bacteria play role in chronic pain. The endocannabinoid system is implicated inflammation pain processing at both central nervous (CNS) levels. In present study, we used low Vitamin D dietary intake mice evaluated possible changes microbiota, signaling. deficiency induced lower microbial diversity characterized by an increase Firmicutes decrease Verrucomicrobia...
Central post-stroke pain (CPSP) and associated depression remain poorly understood pharmacological treatments are unsatisfactory. Recently, microglia activation was suggested to be involved in CPSP pathophysiology. The goal of this study investigate the effectiveness a co-ultramicronized combination N-palmitoylethanolamide luteolin (PEALut) mouse model thalamic hemorrhage (TH)-induced CPSP. TH established through collagenase-IV injection ventral-posterolateral-nucleus. PEALut effects...
The aim of this study was to evaluate bone metabolism in breast-feeding women. Thirty-six healthy women (24-31 yr, mean age 28.1 +/- 1.8 yr) were divided into 2 groups: group A including 18 that exclusively breast-fed for 6 months, and B composed whom lactation inhibited with bromocriptine. Three days 3, 6, 12 months after delivery, distal radius, lumbar spine mineral density (BMD) some the main biochemical parameters turnover assessed. In A, we detected a significant decrease (P < 0.01 vs....
The purinergic system is highly involved in the regulation of microglial physiological processes. In addition to accepted roles for P2 X4,7 and Y12 receptors activated by adenosine triphosphate (ATP) diphosphate, respectively, recent evidence suggests a role A2A receptor cytoskeletal rearrangements. However, expression function A1 (A1AR) microglia still unclear. Several reports have demonstrated possible A1AR microglia, but new study has refuted such evidence. this study, we investigated...
Palmitoylethanolamide (PEA) is an endogenous cannabinoid-like compound in the central nervous system, which can modulate several functions different pathological states, such as inflammation and pain response. We have here investigated effect of PEA (5-10 mg/kg, intraperitoneally) on mechanical allodynia thermal hyperalgesia 3 7 days following peripheral injection formalin. Formalin induced a significant decrease threshold injected contralateral paw. chronic treatment (once per day)...
Background/Aims: Osteoarthritis (OA) is a joint degenerative biomechanical disorder involving immunity, metabolic alterations, inflammation, and cartilage degradation, where chondrocytes play pivotal role. OA has not effective pharmacological treatments new therapeutic targets are needed. Adipokines contribute to the low-grade systemic inflammation in OA. Here, we explored novel molecular mechanisms of sodium butyrate (BuNa) modulating chemotaxis chondrocytes, demonstrating direct...
Scope Virgin olive oil is an essential component of the Mediterranean diet. Its antioxidant and anti‐inflammatory properties are mainly linked to phenolic contents. This study aims evaluate beneficial effects a polyphenol‐rich virgin (HPCOO) or without polyphenols (WPOO) in rats fed high‐fat diet (HFD). Methods results Male Sprague‐Dawley were divided into four groups based on different types diet: (I) standard (STD); (II) HFD; (III) HFD containing WPOO, (IV) HPCOO. HPCOO WPOO induced...
The role of the hydroxycarboxylic acid receptor 2 (HCA2) in retinal damage induced by diabetes has never been explored. In this context, present study highlights an upregulation HCA2 receptors diabetic C57BL6J mice. Moreover, we illustrate that exert anti-inflammatory effect on when activated endogenous ligand β-hydroxybutyrate.Seven-to-10-week-old mice were rendered a single intraperitoneal injection streptozotocin (75 mg/kg body weight) and monitored intermittently over 10-week period...
Neurological dysfunctions are the most impactful and persistent consequences of traumatic brain injury (TBI). Indeed, previous reports suggest that an association between TBI chronic pain syndromes, as well anxio-depressive behaviors, tends to be more common in patients with mild forms TBI. At present, no effective treatment options available for these symptoms. In present study, we used a weight drop mouse model investigate effect commercially 10% Cannabidiol (CBD) oil on both sensorial...
Traumatic brain injury (TBI) represents a major public health problem, which is associated with neurological dysfunction. In severe or moderate cases of TBI, in addition to its high mortality rate, subjects may encounter diverse behavioural dysfunctions. Previous reports suggest that an association between TBI and chronic pain syndromes tends be more common patients mild forms injury. Despite causing minimal damage, (mTBI) often leads persistent psychologically debilitating symptoms, can...
The mechanisms underlying neuropathic pain are poorly understood. Here we show the unexplored role of hydroxyl carboxylic acid receptor type 2 (HCAR2) in models pain. We used an oral treatment with dimethyl fumarate and HCAR2 endogenous ligand β-hydroxybutyrate (BHB) wild-type (WT) HCAR2-null mice. found up-regulation sciatic nerve dorsal root ganglia Accordingly, acute chronic dimethylfumarate (DMF) BHB reduced tactile allodynia. This effect was completely lost mice after a 2-d starvation...