A5049123139- Cannabis and Cannabinoid Research
- Diet, Metabolism, and Disease
- Ion Channels and Receptors
- Sphingolipid Metabolism and Signaling
- Dietary Effects on Health
- Inflammatory Bowel Disease
- Biochemical Analysis and Sensing Techniques
- Neuropeptides and Animal Physiology
- Gastrointestinal motility and disorders
- Fibroblast Growth Factor Research
- Digestive system and related health
- GABA and Rice Research
- Pineapple and bromelain studies
- Garlic and Onion Studies
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- PI3K/AKT/mTOR signaling in cancer
- Phytochemicals and Antioxidant Activities
- Asthma and respiratory diseases
- Infant Health and Development
- Nitric Oxide and Endothelin Effects
- Nerve injury and regeneration
- Cancer Cells and Metastasis
- Chemical synthesis and alkaloids
- Pharmacological Effects of Natural Compounds
University of Naples Federico II
2016-2025
University of Brescia
2019-2025
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2025
MNR Dental College and Hospital
2021
Inonu University
2021
Government Medical College
2021
Brescia University
2019
Humanitas University
2017-2018
National Research Council
2016
Clínica Ruiz
2015
Cannabigerol (CBG) is a safe non-psychotropic Cannabis-derived cannabinoid (CB), which interacts with specific targets involved in carcinogenesis. Specifically, CBG potently blocks transient receptor potential (TRP) M8 (TRPM8), activates TRPA1, TRPV1 and TRPV2 channels, 5-hydroxytryptamine 1A (5-HT1A) receptors inhibits the reuptake of endocannabinoids. Here, we investigated whether protects against colon tumourigenesis. Cell growth was evaluated colorectal cancer (CRC) cells using...
Epilepsy is the most prevalent neurological disease and characterized by recurrent seizures. Here, we investigate (i) anticonvulsant profiles of cannabis-derived botanical drug substances (BDSs) rich in cannabidivarin (CBDV) containing cannabidiol (CBD) acute vivo seizure models (ii) binding CBDV BDSs their components at cannabinoid CB1 receptors.The two (50-422 mg·kg(-1) ) were evaluated three animal seizure. Purified CBD also an isobolographic study to evaluate potential pharmacological...
The non-psychotropic cannabinoid cannabichromene is known to activate the transient receptor potential ankyrin-type1 (TRPA1) and inhibit endocannabinoid inactivation, both of which are involved in inflammatory processes. We examined here effects this phytocannabinoid on peritoneal macrophages its efficacy an experimental model colitis.Murine were activated vitro by LPS. Nitrite levels measured using a fluorescent assay; inducible nitric oxide (iNOS), cyclooxygenase-2 (COX-2) (CB1 CB2 )...
Palmitoylethanolamide (PEA) acts via several targets, including cannabinoid CB1 and CB2 receptors, transient receptor potential vanilloid type-1 (TRPV1) ion channels, peroxisome proliferator-activated alpha (PPAR α) orphan G protein-coupled 55 (GRR55), all involved in the control of intestinal inflammation. Here, we investigated effect PEA a murine model colitis.Colitis was induced mice by intracolonic administration dinitrobenzenesulfonic acid (DNBS). Inflammation assessed evaluating...
Endocannabinoids in tissues controlling energy homeostasis are altered obesity, thus contributing to metabolic disorders. Here we evaluate endocannabinoid dysregulation the small intestine of mice with diet-induced obesity (DIO) and peripheral Zucker lean rats following food deprivation re-feeding.Intestinal transit, evaluated using rhodamine-B-labelled dextran, intestinal levels, measured by liquid chromatography mass spectrometry, were fed normal or high-fat diets (HFDs). Endocannabinoid...
BACKGROUND AND PURPOSE Cannabichromene (CBC) is a major non‐psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin‐1 (TRPA1). Both endocannabinoids TRPA1 may modulate gastrointestinal motility. Here, we investigated effect of CBC on mouse intestinal motility in physiological pathological states. EXPERIMENTAL APPROACH Inflammation was induced small intestine by croton oil. Endocannabinoid (anandamide 2‐arachidonoyl...
Anecdotal and scientific evidence suggests that Cannabis use may be beneficial in inflammatory bowel disease (IBD) patients. Here, we have investigated the effect of a standardized sativa extract with high content cannabidiol (CBD), here named CBD BDS for "CBD botanical drug substance", on mucosal inflammation hypermotility mouse models intestinal inflammation. Colitis was induced mice by intracolonic administration dinitrobenzenesulfonic acid (DNBS). Motility evaluated experimental model...
Dita bark (Alstonia scholaris (L.) R. Br.) is an ethnomedicine used for the management of various ailments. This study aimed to investigate biological properties methanol extract A. (MEAS), through in vivo, vitro and silico approaches alongside its phytochemical profiling. Identification nature bioactive secondary metabolites were studied by established qualitative tests GC–MS analysis. The antidepressant activity was determined forced swimming test (FST) tail suspension (TST) mice....
Cannabidiol is a Cannabis-derived non-psychotropic compound that exerts plethora of pharmacological actions, including anti-inflammatory, neuroprotective and antitumour effects, with potential therapeutic interest. However, the actions cannabidiol in digestive tract are largely unexplored. In present study, we investigated effect on intestinal motility normal (control) mice inflammation.Motility vivo was measured by evaluating distribution an orally administered fluorescent marker along...
Endocannabinoids (via cannabinoid CB(1) receptor activation) are physiological regulators of intestinal motility and food intake. However, their role in the regulation gastric emptying is largely unexplored. The purpose present study was to investigate involvement endocannabinoid system mice fed either a standard diet (STD) or high-fat (HFD) for 14 weeks.Gastric evaluated by measuring amount phenol red recovered stomach after oral challenge; expression analysed quantitative reverse...
The present study explores the neuropharmacological, antinociceptive, antidiarrheal, antioxidant, thrombolytic and cytotoxic activity of methanol extract Psychotria calocarpa leaves (MEPC). In anxiolytic testing MEPC by elevated plus maze test, hole–board test light–dark exhibited a dose-dependent reduction anxiety while open field observed decreased locomotion. administration revealed significant depressant behavior in forced swimming tail suspension test. Additionally, antinociceptive...
Background and purpose: Salvinorin A, the active component of hallucinogenic herb Salvia divinorum , inhibits intestinal motility through activation κ‐opioid receptors (KORs). However, this compound may have target(s) other than KORs in inflamed gut. Because inflammation upregulates cannabinoid endogenous cannabinoids, present study we investigated possible involvement system salvinorin A‐induced delay Experimental approach: Motility vivo was measured by evaluating distribution a fluorescent...
Garlic (Allium sativum L. fam. Alliaceae) is one of the best-researched, best-selling herbal remedies and also commonly used as a food spice. constituents include enzymes (for example, alliinase) sulfur-containing compounds, including alliin, compounds produced enzymatically from alliin allicin). Traditionally, it has been employed to treat infections, wounds, diarrhea, rheumatism, heart disease, diabetes, many other disorders. Experimentally, shown exert antilipidemic, antihypertensive,...