A5054235625- Obstructive Sleep Apnea Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Sleep and Wakefulness Research
- Pulmonary Hypertension Research and Treatments
- Asthma and respiratory diseases
- Lung Cancer Treatments and Mutations
- Cardiovascular and Diving-Related Complications
- Cancer, Hypoxia, and Metabolism
- Airway Management and Intubation Techniques
- Heart Rate Variability and Autonomic Control
- Health and Wellbeing Research
- COVID-19 Clinical Research Studies
- Tracheal and airway disorders
- Air Quality and Health Impacts
- Cancer-related molecular mechanisms research
- Long-Term Effects of COVID-19
- Cancer Cells and Metastasis
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Respiratory Health Research
- Cancer-related gene regulation
- COVID-19 and healthcare impacts
- Medical Research and Treatments
- Mesenchymal stem cell research
Zhongshan Hospital
2016-2025
Fudan University
2016-2025
Sun Yat-sen University
2015-2025
The First Affiliated Hospital, Sun Yat-sen University
2015-2025
Sir Run Run Shaw Hospital
2022
Zhejiang University
2022
Shanghai Chest Hospital
2022
Shanghai Jiao Tong University
2022
Weatherford College
2021
Shanghai Medical College of Fudan University
2014-2020
Background: The transcription factor BACH1 (BTB and CNC homology 1) suppressed endothelial cells (ECs) proliferation migration impaired angiogenesis in the ischemic hindlimbs of adult mice. However, role underlying mechanisms atherosclerosis remain unclear. Methods: Mouse models cell (EC)-specific-Bach1 knockout mice were used to study regulation atherogenesis mechanisms. Results: Genetic analyses revealed that coronary artery disease-associated risk variant rs2832227 was associated with...
Obstructive sleep apnea (OSA) is frequently associated with increased incidence and mortality of pulmonary hypertension (PH). The immune response contributes to artery remodeling OSA-related diseases. immunologic factors linked OSA-induced PH are not well understood. STAT6 crucial in the signaling pathway that modulates response. However, status phosphorylated (p-STAT6) an mouse model remains largely unexplored. Chronic intermittent hypoxia (CIH) plays a role progression OSA. This study...
Obstructive sleep apnea (OSA) associated neurocognitive impairment is mainly caused by chronic intermittent hypoxia (CIH)-triggered neuroinflammation and oxidative stress. Previous study has demonstrated that mitochondrial reactive oxygen species (mtROS) was pivotal for hypoxia-related tissue injury. As a cytosolic multiprotein complex participates in various inflammatory neurodegenerative diseases, NLRP3 inflammasome could be activated mtROS thereby affected the mitochondria-selective...
Emerging evidence shows that signal transducer and activator of transcription 6 (STAT6) plays critical roles in tumor development. We previously found high-level expression STAT6 human lung adenocarcinoma squamous cell carcinoma, specifically infiltrated immune cells located the interstitium. Nevertheless, role signaling carcinogenesis cancer proliferation, its underlying mechanisms remain unclear. This study aimed to investigate as well interaction between microenvironment pulmonary...
Abstract Recently, long noncoding RNAs (lncRNAs) have been widely reported to play pivotal roles in the regulation of human cancers. Although oncogenic property lncRNA small nucleolar RNA host gene 3 (SNHG3) has revealed a variety cancers, functions and regulatory mechanism SNHG3 non‐small‐cell lung cancer (NSCLC) remain be investigated. In this study, we detected upregulated expression NSCLC tissues as well cells through quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR)...
A new Air Quality Health Index (AQHI) was developed in Canada or several single cities as a promising health risk communication tool.To construct national AQHI China and compare its validity predicting daily mortality with the existing (AQI).We established sum of excess total risks associated multiple air pollutants 272 representative Chinese from 2013 to 2015 (termed "total AQHI"). The per unit change pollutant concentrations were determined according time-series analysis each city....
Benzo(a)pyrene (BaP) is a ubiquitous air pollutants, and BaP exposure leads to risk of respiratory diseases. The oversecretion airway mucus high expression mucin 5AC (MUC5AC) are associated with common disorders caused by pollution. We aimed investigate the effect on MUC5AC expression, especially mechanisms which induces gene expression. human epithelial cell NCI-H292 was used test effects in vitro. mRNA protein were assessed real-time quantitative PCR, immunochemistry, western blotting. A...
An adverse role for obstructive sleep apnea (OSA) in cancer aggressiveness and mortality has recently emerged from clinical animal studies, the reasons have not been fully determined. Cancer stem cells (CSCs) are regarded as main cause of carcinoma metastasis. So far, relationship between OSA lung CSCs explored.
Chronic intermittent hypoxia (CIH), as the foremost pathophysiological change of obstructive sleep apnea (OSA), contributes to continued deterioration in renal function. Nucleotide-binding domain like receptor protein 3 (NLRP3) inflammasome is a multiprotein complex that triggers innate immune responses infection and cell stress through activation caspase-1 maturation inflammatory pro-interleukin-1β cytokine. Emerging evidence indicates inhibition NLRP3 ameliorates injury. Nevertheless, it...
Circadian rhythm plays an important role in diverse physiological processes. Abnormal expression of circadian genes is associated with increased risk disease, including different types cancer. The cancer stem cell (CSC) hypothesis suggests that there a small subset stem‑like cells within tumors are responsible for tumor initiation. However, the biological effect on CSCs remains largely unknown. Studies have highlighted protein CLOCK controls key aspects various diseases. In present study,...
Non-small cell lung cancer (NSCLC) patients with activating mutations in the epidermal growth factor receptor (EGFR) are responsive to erlotinib, an EGFR-tyrosine kinase inhibitor (EGFR-TKI). However, secondary somatic EGFR resistant EGFR-TKI treatment. In this study, we investigated effect of curcumin on tumor erlotinib-resistant NSCLC cells. Cell proliferation was determined by MTT assay. Apoptosis examined using TUNEL staining. Protein expression genes Western blot. Tumor assessed a...
Obstructive sleep apnea (OSA) associated chronic kidney disease is mainly caused by intermittent hypoxia (CIH) triggered tissue damage. Receptor for advanced glycation end product (RAGE) and its ligand high mobility group box 1 (HMGB1) are expressed on renal cells mediate inflammatory responses in OSA‐related diseases. To determine their roles CIH‐induced injury, soluble RAGE (sRAGE), the neutralizing antibody, was intravenously administered a CIH model. We also evaluated effect of sRAGE...
Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease, and metabolomics plays hub role in predictive, preventive, personalized medicine (PPPM) related to COPD. This study thus aimed reveal the of induced sputum predicting COPD severity. In this pilot study, total 20 patients were included. The metabolites assayed using liquid chromatography-mass spectrometry (LC-MS/MS) system. Five oxidative stress products (myeloperoxidase (MPO), superoxide dismutase (SOD),...
Abstract To investigate the role of TGF-β and IL-6 in myofibroblasts (MFs) — lung cancer cell interactions, cells (Lewis CTM-167 lines) were stimulated by IL-6, MF-conditioned medium (MF-CM) or MFs, with without signaling inhibitor SB431542 and/or JAK2/STAT3 JSI-124. MFs TGF-β, cell-CM cells, Cell proliferation, levels cytokines, expression mRNA protein determined. Mice bearing xenograft tumors intraperitoneally treated JSI-124 monitored for up to 45 days. In co-culture systems, secreted...
Abstract Hypoglossal motor neurons (HMNs) innervate tongue muscles and play key roles in a variety of physiological functions, including swallowing, mastication, suckling, vocalization, respiration. Dysfunction HMNs is associated with several diseases, such as obstructive sleep apnea (OSA) sudden infant death syndrome. OSA serious breathing disorder the activity during different sleep–wake states. Identifying neural mechanisms by which state-dependent activities are controlled may be helpful...
The transcription factor Bach1 impairs angiogenesis after ischemic injury by suppressing Wnt/β-catenin signaling; however, the specific domains responsible for anti-angiogenic effects of remain unclear. This study determined role BTB domain in angiogenesis. is highly expressed circulating endothelial cells from acute myocardial infarction patients and early induction gene ischemia. Mice were treated with adenoviruses coding GFP (AdGFP), (AdBach1), or a mutant lacking (AdBach1-ΔBTB)...
Abstract Background Growing evidence suggests that cancer stem cells (CSCs) are responsible for initiation in tumors. Bach1 has been identified to contribute several tumor progression, including lung cancer. The role of CSCs remains poorly known. Therefore, the function on was focused currently. Methods expression Bach1, CD133, CD44, Sox2, Nanog and Oct4 mRNA assessed using Real-Time Quantitative Reverse Transcription PCR (RT-qPCR). Protein Nanog, Oct4, p53, BCL2, BAX, p-p38, p-AKT1, c-Fos...