A5077546864- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Glycation End Products research
- Diabetes Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related molecular mechanisms research
- Heart Failure Treatment and Management
- Cell Adhesion Molecules Research
- RNA regulation and disease
- Nuclear Receptors and Signaling
- Lanthanide and Transition Metal Complexes
- Kruppel-like factors research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- interferon and immune responses
- Peroxisome Proliferator-Activated Receptors
- Magnetism in coordination complexes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Angiogenesis and VEGF in Cancer
Ruijin Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Shanghai Institutes for Biological Sciences
2017
Chinese Academy of Sciences
2006-2017
Nanjing Medical University
2016
Second Affiliated Hospital of Nanjing Medical University
2016
Dalian University
2015-2016
Dalian University of Technology
2013-2015
Beihang University
2010-2014
University of Rochester
2012
Atherosclerosis is an inflammatory process due to oxidized low-density lipoprotein (oxLDL) accumulation in macrophages. We investigated the involvement of microRNAs oxLDL and response The expression miR-146a decreases under stimulation. MiR-146a significantly reduces intracellular LDL cholesterol content secretion interleukin 6, 8, chemokine (C-C motif) ligand 2 matrix metallopeptidase 9. Toll-like receptor 4 (TLR4) a relevant target miR-146a, inhibits activation TLR4-dependent signaling...
Background: The transcription factor BACH1 (BTB and CNC homology 1) suppressed endothelial cells (ECs) proliferation migration impaired angiogenesis in the ischemic hindlimbs of adult mice. However, role underlying mechanisms atherosclerosis remain unclear. Methods: Mouse models cell (EC)-specific-Bach1 knockout mice were used to study regulation atherogenesis mechanisms. Results: Genetic analyses revealed that coronary artery disease-associated risk variant rs2832227 was associated with...
The nervous and vascular systems, although functionally different, share many common regulators of function maintenance. Long non-coding RNAs (lncRNAs) are important players in biological processes human disorders. We previously identified a role MALAT1 microvascular dysfunction. However, its neurodegeneration is still unknown. Here, we used the eye as model to investigate retinal neurodegeneration. show that expression significantly up-regulated retinas, Müller cells, primary ganglion cells...
We investigated the association of adipokine C1q/TNF-related protein (CTRP) 1 with coronary artery disease (CAD), and biological vascular effects CTRP1.We analysed CTRP1 levels in sera CAD patients (n = 451) non-CAD controls 686), endarterectomy specimens 32), non-atherosclerotic internal mammary arteries 26), aortic atherosclerotic plaques 15), samples 10). protein-levels were higher sera, specimens, plaques, peripheral blood mononuclear cells (PBMCs) from compared controls, related to...
Endothelial cells (EC) at regions exposed to disturbed flow (d-flow) are predisposed inflammation and the subsequent development of atherosclerosis. We previously showed that thioredoxin interacting protein (TXNIP) was required for tumor necrosis factor-mediated expression vascular cell adhesion molecule-1.We sought investigate role TXNIP in d-flow-induced molecule leukocyte interaction with vessels, mechanisms by which suppresses athero-protective gene expression.Using en face staining...
Background: Chronic inflammatory disorders and dyslipidemia in type 2 diabetes mellitus (T2DM) are essential contributors to the development of atherosclerotic cardiovascular disease. Monocyte high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel simple measure associated positively with body oxidative stress status. However, little known regarding role MHR evaluating carotid intima-media thickness (CIMT), surrogate predictor subsequent vascular events, especially diabetic...
Oxidized low-density lipoprotein (oxLDL)-regulated secretion of inflammatory cytokines in smooth muscle cells (SMCs) is regarded as an important step the progression atherosclerosis; however, its underlying mechanism remains unclear. This study investigated role toll-like receptor 4 (TLR4) oxLDL-induced expression SMCs both vivo and vitro. We found that levels TLR4, interleukin 1-β (IL1-β), tumor necrosis factor-α (TNFα), monocyte chemoattractant protein 1 (MCP-1) matrix metalloproteinase-2...
Background Because of advances in medical treatments, a substantial proportion patients with heart failure (HF) have experienced recovery ejection fraction (EF), termed HF recovered EF (HFrecEF). Insulin resistance (IR) is prevalent and tightly related prognosis. This study investigates the relationship between IR incidence HFrecEF who are nondiabetic. Methods Results A total 262 reduced (HFrEF) were nondiabetic consecutively enrolled. Patients classified into (follow-up EF>40% ≥10% absolute...
Abstract Background Advanced glycation products (AGEs), as endogenous inflammatory mediator, compromise the physiological function of mesenchymal stem cells (MSCs). MSCs have a potential role in cell replacement therapy acute myocardial infarction and ischemic cardiomyopathy. However, mechanisms AGEs on are still not unveiled. Methods Reactive oxygen species (ROS), genes regulation, proliferation migration been detected by AGE-BSA stimulated MSCs. Results We found that vitro stimulation with...
Abstract Background Adverse cardiac remodeling after ST-segment elevation myocardial infarction (STEMI) is a major cause for poor cardiovascular outcomes such as heart failure. The predisposing factors and underlying mechanisms remain not fully understood. This study investigates the association of insulin resistance dysglycemia with left ventricular (LV) STEMI in non-diabetic patients. Methods A total 485 subjects who underwent primary percutaneous coronary intervention were consecutively...
In a previous study, we established diabetic and nondiabetic minipig models with coronary artery in-stent restenosis (ISR). Mass spectrometry showed that high-mobility group box (HMGB) 2 level was higher in ISR than non-ISR tissue from minipigs. We here investigated whether serum HMGB2 levels were related to disease patients. The effect of evaluated mice femoral wire injury human aortic smooth muscle cells.From 2513 patients undergoing intervention follow-up angiography at ≈1 year, 262...
High-mobility group box (HMGB) family is related to inflammatory diseases. We investigated whether serum HMGB2 levels are myocardial infarction (MI) severity and major adverse cardiac events (MACE) during MI. included 432 consecutive patients with ST-segment elevation 312 controls. Serum were significantly higher in MI than Increased associated MACE negatively ejection fraction patients. was an independent determinant of logistic regression analysis. protein (10 μg) or saline injected...
The present study aimed to investigate the relationship between serum levels of secretory vimentin and coronary artery disease (CAD). biological effect was ascertained by experiments.We analysed in CAD patients (n = 288) non-CAD controls 195) ELISA. To evaluate pro-inflammatory effects secreted vimentin, human aortic endothelial cells (HAECs) peripheral blood mononuclear (PBMCs) were treated with recombinant or saline. Intraperitoneal injection (1 μg/each) saline performed every other day...
Abstract Aims Members of the chromogranin family play a role in angiogenesis. One such biologically active peptide, generated through processing A, is vasostatin-2. This study aimed at assessing association serum vasostatin-2 levels with coronary collateral vessels (CCV) diabetic patients chronic total occlusions (CTO) and effects on angiogenesis mice hindlimb or myocardial ischemia. Methods results Serum 452 CTO were evaluated. The status CCV was categorized according to Rentrop score....
Excessive formation of advanced glycation end products (AGE) and lipid accumulation in macrophages play a pivotal role the progression atherosclerosis diabetes mellitus. This study aimed to determine molecular link between AGE-induced fatty acid binding protein 4 (FABP4) expression macrophage accumulation. AGE-BSA markedly increased FABP4 via engagement RAGE, 35-kDa transmembrane receptor that is able bind extracellular AGE responsible for corresponding signal transduction, whereas knockdown...
We investigated whether or to what extent the interaction of lipoprotein (a) [Lp(a)] with cholesterol-containing lipids was associated angiographic coronary collateralization in type 2 diabetic patients chronic total occlusion.Serum levels Lp(a), cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density (HDL-C), and triglyceride were determined non-HDL-C calculated 706 578 non-diabetic stable artery disease occlusion at least one major artery. The degree collaterals supplying...
Abstract Background Patients with type 2 diabetes are under substantially higher risk of in-stent restenosis (ISR) after coronary stent implantation. We sought to investigate whether visit-to-visit HbA 1c variability is a potential predictor ISR in diabetic patients Methods consecutively enrolled who underwent successful elective percutaneous intervention and performed follow-up angiography around 12 months. The incidence its relationship variability, expressed as coefficient variation (CV),...
Plaque progression (PP) is critical between subclinical atherosclerosis and plaque rupture. Small dense low-density lipoprotein cholesterol (sdLDL-C) considered as the most atherogenic lipoprotein. This study aims to investigate relationship sdLDL-C level PP in patients with stable coronary artery disease. We conducted a retrospective analysis of 146 lesions 86 by repeat intravascular ultrasound examinations from January 2020 May 2023. was determined increases percent atheroma volume,...