A5037151759- Lysosomal Storage Disorders Research
- Antibiotic Resistance in Bacteria
- Heart Failure Treatment and Management
- Carbohydrate Chemistry and Synthesis
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Antibiotics Pharmacokinetics and Efficacy
- Atrial Fibrillation Management and Outcomes
- Misinformation and Its Impacts
- Viral Infections and Immunology Research
- Genetic factors in colorectal cancer
- Histone Deacetylase Inhibitors Research
- Vaccine Coverage and Hesitancy
- Pain Management and Placebo Effect
- Peptidase Inhibition and Analysis
- Autism Spectrum Disorder Research
- Glycogen Storage Diseases and Myoclonus
- Cardiac, Anesthesia and Surgical Outcomes
- Systemic Sclerosis and Related Diseases
- Acute Ischemic Stroke Management
- Cardiac Structural Anomalies and Repair
- Complementary and Alternative Medicine Studies
- Analytical Chemistry and Chromatography
- Biochemical and Molecular Research
- Cardiovascular Function and Risk Factors
Duke University
2022-2024
Blacktown & Mount Druitt Hospital
2020-2024
Western Sydney University
2024
Sydney Local Health District
2022-2024
McGovern Institute for Brain Research
2023
Duke Medical Center
2017-2023
Duke University Hospital
2023
Princeton University
2022
University of Illinois Chicago
2022
Novartis Institutes for BioMedical Research
2019
<h3>Importance</h3> The Choosing Wisely campaign consists of more than 70 lists produced by specialty societies medical practices or procedures minimal clinical benefit to patients in most situations, with recommendations regarding judicious use. <h3>Objective</h3> To quantify the frequency and trends some earliest using nationwide commercial health plan population-level data. <h3>Design, Setting, Participants</h3> Retrospective analysis claims data for members Anthem-affiliated plans....
Heart failure with preserved ejection fraction (HFpEF) poses therapeutic challenges due to the limited treatment options. Building upon our previous research that demonstrates efficacy of histone deacetylase 6 (HDAC6) inhibition in a genetic cardiomyopathy model, we investigate HDAC6's role HFpEF their shared mechanisms inflammation and metabolism. Here, show inhibiting HDAC6 TYA-018 effectively reverses established heart its associated symptoms male mouse models. Additionally, mice lacking...
Study objectiveAcute musculoskeletal pain in emergency department (ED) patients is frequently severe and challenging to treat with medications alone. The purpose of this study was determine the feasibility, acceptability, effectiveness adding ED acupuncture acute episodes neck, back, extremities.MethodsIn pragmatic 2-stage adaptive open-label randomized clinical trial, Stage 1 identified whether auricular (AA; based on battlefield protocol) or peripheral (PA; needles head, extremities only),...
The authors assessed the safety and resource use associated with fast-track cardiac anesthesia (FTCA) after coronary artery bypass graft surgery (CABG) over a 1-yr period.One hundred twenty patients were initially randomized to FTCA (n = 60) or conventional anesthetic for primary elective CABG surgery. Patients followed index through linkage universal administrative databases. Acute care hospital readmission rates length of stay (LOS) downstream health resources compared. Resource was...
Previous studies have shown that patients newly diagnosed with colorectal cancer (CRC) requiring emergency admission to hospital or those presenting obstruction perforation (defined here as OPE) advanced disease. The objective was conduct a population-based study among persons new diagnosis of CRC identify factors associated OPE in Ontario.We analyzed data from the following databases: Canadian Institute for Health Information (CIHI), Ontario Insurance Plan (OHIP), and Registered Persons...
Resistance in Gram-negative bacteria to β-lactam drugs is mediated primarily by the expression of β-lactamases, and co-dosing β-lactams with a β-lactamase inhibitor (BLI) clinically proven strategy address resistance. New β-lactamases that are not impacted existing BLIs spreading creating need for development novel broader spectrum BLIs. IID572 broad BLI diazabicyclooctane (DBO) class able restore antibacterial activity piperacillin against piperacillin/tazobactam-resistant clinical...
This paper investigates multiphase flying capacitor multilevel (FCML) converters with coupled inductors for ripple reduction and intrinsic voltage balancing. FCML topologies are two commonly used techniques to reduce power conversion stress, current, improve system performance. Combining opens a wide range of design opportunities. The shown intrinsically balance the voltages, granting greater robustness disturbances compared uncoupled natural offered by structure derived. theoretical...
ABSTRACT Mice lacking expression of the homologous phosphatases Sts-1 and Sts-2 (Sts −/− mice) are resistant to disseminated candidiasis caused by fungal pathogen Candida albicans . To better understand immunological mechanisms underlying enhanced resistance Sts mice, we examined kinetics clearance at early time points. In contrast rapid C. growth seen in normal kidneys during first 24 h postinfection, observed a reduction kidney CFU within mice beginning 12 18 postinfection. This...
Importance Large segments of the US population’s primary health care access occurs in emergency departments (EDs). These groups have disproportionately high COVID-19 vaccine hesitancy and lower uptake. Objective To determine whether provision messaging platforms EDs increases acceptance uptake unvaccinated patients. Design, Setting, Participants This prospective cluster randomized clinical trial was conducted at 7 hospital 4 cities from December 6, 2021, to July 28, 2022. Noncritically ill...
Infantile-onset Pompe disease (IOPD) is a glycogen storage caused by deficiency of acid alpha-glucosidase (GAA). Treatment with recombinant human GAA (rhGAA, alglucosidase alfa) enzyme replacement therapy (ERT) significantly improves clinical outcomes; however, many IOPD children treated rhGAA develop anti-drug antibodies (ADA) that render the ineffective. Antibodies to are driven T cell responses sequences in differ from individuals' native (nGAA). The goal this study was tool for...
With the increasing use of colonoscopy there is growing concern about quality these procedures.To evaluate rates complete colonic evaluation after an incomplete and their associated factors.Men women > or =50 years old living in Ontario on January 1, 1997 who did not have a prior history colorectal cancer, inflammatory bowel disease, resection comprised inception cohort. Receipt between December 31, 2002 was determined. Individuals were followed over 1 year time from to estimated using...
Carbapenem-resistant Acinetobacter baumannii (CRAB) can cause serious infections that are associated with high mortality rates. During the course of an infection, many CRAB isolates able to form biofilms, which recalcitrant several antibiotics and be difficult treat. Polymyxin-based regimens a first-line treatment option for infections, but they have not been optimized against both planktonic biofilm phases growth. The objective this study was identify polymyxin-based combinations active...
TPS4151 Background: Patients (pts) with HCC have a poor prognosis. Effective treatments are limited, particularly in Asia, which carries about 80% of the burden. In Phase I trial (Falchook et al. J Clin Oncol 2013:31(Suppl):2506), highly selective c-Met inhibitor MSC2156119J showed promising antitumor activity and recommended II dose was determined (RP2D; 500 mg/d). This Ib/II, multicenter, open-label evaluates efficacy monotherapy first-line treatment vs sorafenib pts MET+ advanced...
<title>Abstract</title> Recent results suggest that autistic individuals find it challenging to temporally coordinate their actions with predictable external cues, as indicated, for instance, by lower accuracy in synchronizing finger taps an auditory metronome compared non-autistic peers. However, is not yet clear whether these difficulties are driven primarily motor or perceptual impairments. We recruited and participants online study which tested both tapping synchronization continuation...
Abstract Background We conducted in-depth interviews to characterize reasons for COVID-19 vaccine hesitancy in emergency department (ED) patients and developed messaging platforms that may address their concerns. In this trial, we seek determine whether provision of these EDs will be associated with greater acceptance uptake unvaccinated ED patients. Methods This is a cluster-randomized controlled trial (RCT) evaluating our seven hospital (mix academic, community, safety-net EDs) four US...