A5079033247- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Developmental Biology and Gene Regulation
- Pancreatic function and diabetes
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Signaling Pathways in Disease
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Angiogenesis and VEGF in Cancer
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Cardiomyopathy and Myosin Studies
- Plant Molecular Biology Research
- Microtubule and mitosis dynamics
Kaiser Permanente South San Francisco Medical Center
2024
OncoMed (United States)
2010-2020
University of Kentucky
2018-2019
Almac (United Kingdom)
2016
Istituto Oncologico Veneto
2014
Université Claude Bernard Lyon 1
2014
University of Michigan
2012-2013
Michigan Center for Translational Pathology
2013
University of California, San Francisco
2013
Laboratoire d’immunologie intégrative du cancer
2013
Recent observations indicate that, in several types of human cancer, only a phenotypic subset cancer cells within each tumor is capable initiating growth. This functional operationally defined as the “cancer stem cell” (CSC) subset. Here we developed CSC model for study colorectal (CRC). Solid CRC tissues, either primary tissues collected from surgical specimens or xenografts established nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice, were disaggregated into single-cell...
Breast cancers contain a minority population of cancer cells characterized by CD44 expression but low or undetectable levels CD24 (CD44+CD24-/low) that have higher tumorigenic capacity than other subtypes cells.We compared the gene-expression profile CD44+CD24-/low breast-cancer with normal breast epithelium. Differentially expressed genes were used to generate 186-gene "invasiveness" gene signature (IGS), which was evaluated for its association overall survival and metastasis-free in...
The Wnt/β-catenin pathway, which signals through the Frizzled (Fzd) receptor family and several coreceptors, has long been implicated in cancer. Here we demonstrate a therapeutic approach to targeting Wnt pathway with monoclonal antibody, OMP-18R5. This initially identified by binding 7, interacts five Fzd receptors conserved epitope within extracellular domain blocks canonical signaling induced multiple members. In xenograft studies minimally passaged human tumors, this antibody inhibits...
STAT proteins (signal transducers and activators of transcription) activate distinct target genes despite having similar DNA binding preferences. The transcriptional specificity was investigated on natural sites near the interferon-gamma gene. These are arranged in multiple copies required cooperative interactions for binding. conserved amino-terminal domain binding, although this not essential dimerization or to a single site. Cooperative enabled recognize variations consensus can be...
The periodic, seven-stripe pattern of the primary pair-rule gene even-skipped (eve) is initiated by crude, overlapping gradients maternal and gap proteins in early Drosophila embryo. Previous genetic studies suggest that one stripes, stripe 2, morphogen bicoid (bcd) protein hunchback (hb), while borders are formed selective repression, involving giant (gt) anterior regions Krüppel (Kr) posterior regions. Here, we present several lines evidence consistent with this model for 2 expression,...
The Notch pathway plays an important role in both stem cell biology and cancer. Dysregulation of signaling has been reported several human tumor types. In this report, we describe the development antibody, OMP-59R5 (tarextumab), which blocks Notch2 Notch3 signaling.We utilized patient-derived xenograft tumors to evaluate antitumor effect OMP-59R5. Immunohistochemistry, RNA microarray, real-time PCR, vivo serial transplantation assays were employed investigate mechanisms action...
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with arrhythmias and an increased risk of sudden death. Currently, there are no approved treatments that address the underlying genetic cause this disease, representing significant unmet need. Mutations in Plakophilin-2 (PKP2), encoding desmosomal protein, account for approximately 40% ARVC cases result reduced gene expression.
Heart failure with preserved ejection fraction (HFpEF) poses therapeutic challenges due to the limited treatment options. Building upon our previous research that demonstrates efficacy of histone deacetylase 6 (HDAC6) inhibition in a genetic cardiomyopathy model, we investigate HDAC6's role HFpEF their shared mechanisms inflammation and metabolism. Here, show inhibiting HDAC6 TYA-018 effectively reverses established heart its associated symptoms male mouse models. Additionally, mice lacking...
The transcription factors NFAT and AP-1 have been shown to be essential for inducible interleukin-2 (IL-2) expression in activated T cells. has previously reported bind two sites the IL-2 promoter: association with at distal antigen response element -280 -135. On basis of DNase I footprinting recombinant proteins, gel shift assays, transfection experiments, we identified three additional promoter. Strikingly, all five are full induction promoter activity T-cell receptor stimulation. Four...