A5065338156- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Pain Management and Opioid Use
- Pharmaceutical Practices and Patient Outcomes
- Pain Management and Placebo Effect
- Complementary and Alternative Medicine Studies
- Opioid Use Disorder Treatment
- Acupuncture Treatment Research Studies
- Musculoskeletal pain and rehabilitation
- Systemic Sclerosis and Related Diseases
- Healthcare professionals’ stress and burnout
- Pharmacogenetics and Drug Metabolism
- Prenatal Screening and Diagnostics
- Epigenetics and DNA Methylation
- Pharmacological Effects and Toxicity Studies
- Nursing education and management
- Pediatric Pain Management Techniques
- Pharmaceutical studies and practices
- COVID-19 and Mental Health
- Pain Mechanisms and Treatments
- Family and Patient Care in Intensive Care Units
- Medication Adherence and Compliance
- Inflammatory Bowel Disease
- Mobile Health and mHealth Applications
- Healthcare Policy and Management
Duke University
2018-2025
Florida College
2023
Emory University
2023
University of Florida
2023
University of Arizona
2023
Arthritis Society
2021
Canadian Institutes of Health Research
2021
University of Pittsburgh
2017-2019
Indiana University – Purdue University Indianapolis
2014-2018
Indiana University
2018
Embedded pragmatic clinical trials (ePCTs) play a vital role in addressing current population health problems, and their use of electronic record (EHR) systems promises efficiencies that will increase the speed volume relevant generalizable research. However, as number ePCTs using EHR-derived data grows, so does risk research become more vulnerable to biases due differences capture access care for different subsets population, thereby propagating inequities healthcare system. We identify 3...
Study objectiveAcute musculoskeletal pain in emergency department (ED) patients is frequently severe and challenging to treat with medications alone. The purpose of this study was determine the feasibility, acceptability, effectiveness adding ED acupuncture acute episodes neck, back, extremities.MethodsIn pragmatic 2-stage adaptive open-label randomized clinical trial, Stage 1 identified whether auricular (AA; based on battlefield protocol) or peripheral (PA; needles head, extremities only),...
Abstract Understanding patient experiences, quality of life, and treatment needs in individuals with sickle cell disease (SCD) is essential promoting health well‐being. We used measures from the Adult Sickle Cell Quality Life Measurement Information System (ASCQ‐Me), Patient Reported Outcomes (PROMIS), Neurological Disorders (NeuroQol) to evaluate pain impact, sleep social functioning, depressive symptoms, tiredness, cognitive function (collectively, reported outcomes [PROs]) identify...
Objective Acupuncture is an evidence-based pain treatment in clinic settings, but its optimal delivery has not been established emergency departments (EDs). As part of adaptive pragmatic randomized controlled trial ED acupuncture for acute musculoskeletal (NCT04290741), we embedded a qualitative evaluation acceptability and suggestions improvement from study participants receiving the ED. Methods Semi-structured interviews conducted remotely evaluated factors impacting patients’...
Vaso-occlusive events (VOEs) are the primary cause of acute pain in individuals with sickle cell disease (SCD), where high-dose opioids current standard treatment. Ketamine, a non-opioid analgesic, holds potential for managing SCD due to its opioid-sparing properties. This study aimed explore barriers and facilitators an inpatient clinical trial ketamine infusion treatment pain. A mixed-methods design integrated quantitative survey data from 70 emergency medicine clinicians qualitative...
Introduction Sex-based clinical outcome differences in sickle cell disease (SCD) remain largely unknown despite evidence that female sex is associated with an increased lifespan. To better characterize sex-based SCD, we assessed pain, treatment characteristics, laboratory measures and complications among males females currently enrolled the Sickle Cell Disease Implementation Consortium (SCDIC) registry. Methods The SCDIC consists of eight comprehensive SCD centers one data coordinating...
Embedded pragmatic clinical trials (ePCTs) are conducted during routine care and have the potential to increase knowledge about effectiveness of interventions under real world conditions. However, many rely on data from electronic health record (EHR) data, which subject bias incomplete poor quality, lack representation people who medically underserved, implicit in EHR design. This commentary examines how use might exacerbate potentially inequities. We offer recommendations for...
People with sickle cell disease frequently use complementary and integrative therapies to cope their pain, yet few studies have evaluated effectiveness. The 3-arm, 3-site pragmatic Hybrid Effectiveness-implementation Trial of Guided Relaxation Acupuncture for Chronic Sickle Cell Disease Pain (GRACE) has 3 priorities: (1) evaluate guided relaxation acupuncture improve pain control; (2) determine the most appropriate effective treatment sequence any given patient based on unique...
Prior to implementing a trial evaluate the economic costs and clinical outcomes of pharmacogenetic testing in large safety net health care system, we determined number patients taking targeted medications their encounter sites.Using 1-year electronic medical record data, evaluated who had started one or more 30 known pharmacogenomically actionable sites visited.Results showed 7039 unique target within 12-month period with visits 73 system.Findings suggest that type large-scale, multi-drug,...
Abstract Objective To describe the prevalence of infertility and treatment seeking among people enrolled in Sickle Cell Disease Implementation Consortium (SCDIC) registry identify sociodemographic clinical correlates infertility. Design Cross‐sectional. Participants The study population included 2108 women men (≥18 years age) SCDIC who completed fertility questionnaire. Results All participants infertility‐specific questions were analysis (1224 females; 884 males). Of these, 16.9% males...
Abstract Sickle cell disease (SCD) affects ∼100 000 predominantly African American individuals in the United States, causing significant cellular damage, increased complications, and premature death. However, contribution of epigenetic factors to SCD pathophysiology remains relatively unexplored. DNA methylation (DNAm), a primary mechanism for regulating gene expression response environment, is an important driver normal aging. Several DNAm clocks have been developed serve as proxy We...
ABSTRACT Dilemmas regarding opioid prescribing for chronic pain frequently occur within health care settings. The ethical principles of autonomy, beneficence, nonmaleficence, and justice, as well the ethics, can assist in addressing these opioid-related dilemmas. purpose this clinical case study is to provide a highlighting an dilemma then identify transition considerations; address questions that nurse practitioners (NPs) may encounter practice when providing individuals living with who...