A5100426917- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Systemic Lupus Erythematosus Research
- COVID-19 Clinical Research Studies
- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Autophagy in Disease and Therapy
- Hemoglobinopathies and Related Disorders
- Corneal surgery and disorders
- Blood groups and transfusion
- Long-Term Effects of COVID-19
- Otitis Media and Relapsing Polychondritis
- Retinal Development and Disorders
- Proteoglycans and glycosaminoglycans research
- Advanced Glycation End Products research
- Retinal Imaging and Analysis
- Traumatic Brain Injury and Neurovascular Disturbances
- HIV, Drug Use, Sexual Risk
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Corneal Surgery and Treatments
- Inflammasome and immune disorders
- Lung Cancer Treatments and Mutations
Second Hospital of Yichang
2025
China Three Gorges University
2012-2025
Hunan Cancer Hospital
2024
Central South University
2024
Yichang Central People's Hospital
2016-2024
Guangxi Center for Disease Prevention and Control
2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2013-2024
BeiGene (China)
2023
First Affiliated Hospital of Xi'an Jiaotong University
2022
Zhejiang Sci-Tech University
2009-2022
While the outbreak of coronavirus disease 2019 (COVID-19) has resulted in more than 100 000 infected individuals China and worldwide, there are few reports on association severe acute respiratory syndrome 2 (SARS-CoV-2) with ocular abnormalities. Understanding manifestations patients COVID-19 by ophthalmologists others may facilitate diagnosis prevention transmission disease.To investigate viral prevalence conjunctiva COVID-19.In this case series, treated from February 9 to 15, 2020, at a...
Coronavirus disease 2019 (COVID-19)2 has emerged as a global pandemic. However, effective treatments for this are still unclear, safe and efficient therapies urgently needed. Qingfei Paidu decoction (QPD)3 is strongly recommended in the Chinese Novel Pneumonia Diagnosis Treatment Plan (Provisional 6th Edition). clinical research data on effects of QPD COVID-19 scarce. Our study aimed to explore combined treatment with Western medicine COVID-19. In study, 63 patients confirmed were analyzed....
The COVID-19 is a public health emergency. patient the main source of infection, and asymptomatic infective can also be infection (Bhadelia 2020). route transmission through respiratory droplets contact (Burki It not clear whether 2019-nCoV transmitted mucous membrane eye. S-protein SARS-like coronavirus interact with human ACE2 protein infect epithelial cells (Ge et al. 2013). cornea conjunctiva express receptor, which theoretically bind to cause infection. Our hospital from epidemic area....
MicroRNA-146a (miR-146a) is involved in certain immune-mediated diseases. Transcription factor Ets-1 strongly affects miR-146a promoter activity and directly regulates expression. This study was performed to investigate the association of gene polymorphisms with Behçet's disease (BD) Vogt-Koyanagi-Harada (VKH) a Chinese Han population.A total 809 patients BD, 613 VKH 1132 normal controls were genotyped for miR-146a/rs2910164, rs57095329 rs6864584, Ets-1/rs1128334 rs10893872 using PCR...
Abstract Scar formation seriously affects the repair of damaged skin especially in adults and excessive inflammation has been considered as reason. The self-assembled peptide-hydrogels are ideal biomaterials for wound healing due to their similar nanostructure natural extracellular matrix, hydration environment serving drug delivery systems. In our study, resveratrol, a polyphenol compound with anti-inflammatory effect, is loaded into peptide-hydrogel (Fmoc-FFGGRGD) form dressing (Pep/RES)....
To clarify the effect of aspirin on mortality and viral duration in adults infected with respiratory syndrome coronavirus 2 (SARS-Cov-2).After propensity score-matched (PSM) case-control analyses 24 pairs patients were enrolled followed up for months. Both 30-day 60-day group significantly lower than that non-aspirin (P = .021 P .030, respectively). The time between groups was not different .942).Among (with hypertension, cardiovascular diseases) SARS-Cov-2, low-dose medication (100 mg/day)...
Purpose.: Behçet's disease (BD) is a chronic systemic inflammatory disorder of unknown etiology. Toll-like receptors (TLRs) are critical in the innate immune response to microbial invaders. In this study we investigated role TLRs pathogenesis BD. Methods.: TLR2/4 expression and IL-1β reactive oxygen species (ROS) production were studied monocyte-derived macrophages (MDMs) obtained from BD patients, acute anterior uveitis (AAU) healthy controls using real-time PCR, flow cytometry, ELISA. The...
Aims To characterise the clinical features of human leucocyte antigen (HLA)-B27 + acute anterior uveitis (AAU) patients with or without ankylosing spondylitis (AS) and investigate retinal vascular involvement in these patients. Methods A total 1056 HLA-B27 AAU (1525 eyes) were retrospectively studied from April 2008 to February 2016. Patients divided into AS − group. Clinical including onset uveitis, laterality, age at first attack, examinations, best corrected visual acuity (BCVA),...
Purpose: To investigate the effectiveness, visual outcome, and prognostic factors of Vogt–Koyanagi–Harada (VKH) disease treatment with a reduced dose corticosteroids combined immunosuppressive agents.Methods: The clinical characteristics, auxiliary examinations, result, in VKH patients were analyzed.Results: A total 998 divided into posterior uveitis group (Group1), anterior uveal involvement (Group 2), recurrent granulomatous 3). Reduced doses agents used for 1–1.5 years. Uveitis was...
Purpose: To characterize the clinical features of scleritis in Chinese patients.Methods: The history, demographics, ocular findings, auxiliary examination complications, systemic diseases and therapeutic effects were analyzed retrospectively.Results: study included 124 male 169 female patients with scleritis. Anterior posterior were, respectively, found 243 42 patients. other eight had both anterior involvement. mean age onset was 39.4 years. Systemic associated mainly rheumatoid arthritis...
Purpose: To measure changes in the choroidal vascularity index (CVI) chronic Vogt–Koyanagi–Harada (VKH) disease during a recurrent anterior uveitis attack.Methods: Forty VKH patients and 40 normal controls were included this study. Choroidal images recorded before attack, as well after appropriate treatment. CVI was measured by binarization technique using ImageJ software (Bethesda, MD).Results: The 0.75 ± 0.09 quiescent patients, which significantly higher compared to healthy (0.70 0.05, p...
Aim: Liver transplantation is the only currently effective therapy for end‐stage chronic liver disease and severe acute failure, but its use limited by high cost a shortage of allografts. Here we explored effectiveness transplanting adipose‐derived stem cells (ADSCs) into rats with experimentally induced injury. Methods: ADSCs obtained from were hepatogenic in vitro MAPK pathways inhibitors preconditioning. In vivo , transplanted via different routes serum function markers post‐operative...
Hyperglycemia and hypertension are considered to be the two leading risk factors for vascular disease in diabetic patients. However, few pharmacologic agents could provide a combinational therapy controlling hyperglycemia at same time diabetes. The objectives of this study investigate whether berberine treatment directly reduce blood pressure identify molecular mechanism underlying protection rats. Berberine was intragastrically administered with different dosages 50, 100 200 mg/kg/day rats...
This study investigated the biomechanical properties of human trabecular meshwork (TM) tissue under conditions mimicking physiological and pathological states, examining interplay between mechanical stress, glucocorticoid treatment, extracellular matrix remodeling in glaucoma pathophysiology. Fresh TM samples (n = 112) from 28 donor eyes were subjected to various experimental conditions: pressure (15 mmHg), elevated (30 dexamethasone treatment (100 nM), combined pressure-dexamethasone...
Vascular dysfunction is a distinctive phenotype in diabetes mellitus. Current treatments mostly focus on the tight glycemic control and few of these have been designed to directly recover vascular diabetes. As classical natural medicine, berberine has explored as possible therapy for DM. In addition, it reported that an extra-protective effect diabetic dysfunction. However, little known whether treatment could ameliorate smooth muscle contractility independent functional endothelium under...