A5100644350- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Virus-based gene therapy research
- Ion channel regulation and function
- Animal Genetics and Reproduction
- Mesenchymal stem cell research
- Neuroscience and Neural Engineering
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Cell death mechanisms and regulation
- Circular RNAs in diseases
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- 3D Printing in Biomedical Research
- MicroRNA in disease regulation
- Muscle Physiology and Disorders
- Renal and related cancers
Tianjin Medical University General Hospital
2025
Pratt Institute
2020
Shanghai Tenth People's Hospital
2020
Tongji University
2020
Duke University
2020
Xuzhou Medical College
2014
National University of Singapore
2013
Chinese Academy of Sciences
2009-2011
Shanghai Jiao Tong University
2006-2011
Shanghai Institutes for Biological Sciences
2011
A window to the embryo Mammalian embryonic development is a complex process, continuously changing in space and time. Q. Huang et al. designed an abdominal image mouse embryos utero from day 9.5 birth. Using this technique, they visualized dynamic activities during organ formation, including neurotransmission cell division brain, autophagy retina, viral gene delivery, placental drug transfer. They also tracked diverging fates of human neural crest cells interspecies chimeras. Science , issue p. 181
ABSTRACT Background Glioma stem cells (GSCs) contribute to the initiation, recurrence, metastasis, and drug resistance of glioblastoma multiforme (GBM). Long noncoding RNAs (lncRNAs) are critical modulators in development progression GBM; however, specific lncRNAs related GSCs remain largely unexplored. This study aims identify dysregulated GSCs, unravel their contributions GBM progression, propose new targets for diagnosis treatment. Methods GeneChip analysis was utilized GSCs. The...
Significance Glutamate is the principal excitatory neurotransmitter in brain. Kainate receptors, a subfamily of ionotropic glutamate mediate pre- and postsynaptic actions glutamate. Overactivation kainate receptors plays an important role neurodegeneration after ischemic stroke. Because Src kinases show increased activity brain ischemia, we evaluated their roles regulating receptor function ischemia. Our results demonstrate that bind to phosphorylate GluK2 at Y590 facilitate kainate-evoked...
Embryonic stem cell (ESC)-based therapy is a promising treatment for neurodegenerative diseases. But there always risk of tumor formation that due to contamination undifferentiated ESCs. To reduce the and improve ESC-based therapy, we have established novel strategy by which can selectively eliminate cells derived from ESCs but spare differentiated cells. In this study, generated caspase-1-ESC line transfected with mifepristone-regulated caspase-1 expression system. Mifepristone induced...
The breakthrough in derivation of human-induced pluripotent stem cells (hiPSCs) provides an approach that may help overcome ethical and allergenic challenges posed numerous medical applications involving human cells, including neural stem/progenitor (NSCs). Considering the great potential NSCs targeted cancer gene therapy, we investigated this study tumor tropism hiPSC-derived attempted to enhance by manipulation biological activities proteins are involved regulating migration toward cells....
The direct reprogramming of somatic cells into induced neural progenitor (iNPCs) has been envisioned as a promising approach to overcome ethical and clinical issues pluripotent stem cell transplantation. We previously reported that astrocyte-derived (iPSCs) have more tendencies for neuronal differentiation than fibroblast-derived iPSCs. However, the differences neurogenic potential between iNPCs (AiNPCs) from non-neural origins, such (FiNPCs), underlying mechanisms remain unclear. Our...