A5037927261- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- ATP Synthase and ATPases Research
- Cellular transport and secretion
- Nitric Oxide and Endothelin Effects
- Computational Drug Discovery Methods
- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- interferon and immune responses
- Melanoma and MAPK Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Heat shock proteins research
- Cholinesterase and Neurodegenerative Diseases
- Autophagy in Disease and Therapy
- Ion channel regulation and function
- Redox biology and oxidative stress
- Memory and Neural Mechanisms
- RNA regulation and disease
- Nicotinic Acetylcholine Receptors Study
Xuzhou Medical College
2008-2024
China Pharmaceutical University
2019
Nanjing Medical University
2012
Abstract Activated small ubiquitin-like modifiers (SUMOs) have been implicated in neuropathological processes following ischemic stroke. However, the target proteins of SUMOylation and their contribution to neuronal injury remain be elucidated. MLK3 (mixed-lineage kinase 3), a member mitogen-activated protein (MAPKKK) family, is critical regulator lesions cerebral ischemia. Here, we found that increases both global focal rodent models primary oxygen glucose deprivation (OGD). SUMO1...
Src family protein tyrosine kinases (SrcPTKs) have been implicated in the pathogenesis of brain ischemia and Alzheimer's disease (AD). In this study, we investigated whether Fyn kinases, two major members SrcPTKs brain, distinct roles oxygen glucose deprivation (OGD) amyloid-β peptide (Aβ)-induced neuronal apoptosis.The DAPI staining caspase-3 activation analysis showed that small interfering RNAs (siRNAs) knockdown or attenuated SH-SY5Y cells apoptosis after OGD Aβ treatment. had a more...
PSD (postsynaptic density)-95, a scaffold protein that tethers NMDA (N-methyl-D-aspartate) receptors to signal molecules, is implicated in pathological events resulting from excitotoxicity. The present study demonstrates brain ischaemia and reperfusion increase the tyrosine phosphorylation of PSD-95 rat hippocampus. PP2, specific inhibitor SrcPTKs (Src family kinases), prevents ischaemia-induced increases not only PSD-95, but also interaction between Src kinases. phosphorylated either by...
Significance Glutamate is the principal excitatory neurotransmitter in brain. Kainate receptors, a subfamily of ionotropic glutamate mediate pre- and postsynaptic actions glutamate. Overactivation kainate receptors plays an important role neurodegeneration after ischemic stroke. Because Src kinases show increased activity brain ischemia, we evaluated their roles regulating receptor function ischemia. Our results demonstrate that bind to phosphorylate GluK2 at Y590 facilitate kainate-evoked...
Aims: Neuronal nitric oxide synthase (nNOS) and (NO) signaling have been implicated in learning, memory, underlying long-lasting synaptic plasticity. In this study, we aimed at detecting whether nNOS is a target protein of SUMOylation the hippocampus its contributions to hippocampal long-term potentiation (LTP) transmission. Results: We showed that N-methyl-d-aspartate receptor-dependent neuronal activity enhancement induced attachment small ubiquitin-like modifier 1 (SUMO1) nNOS. Protein...
MLK3 physically interacts with GluK2 by anti bait coimmunoprecipitation ( View interaction )
Neuronal activity regulates spatial distribution of the SUMOylation system in cytosolic and dendritic sites, which has been implicated learning, memory, underlying synaptic structural functional remodeling hippocampus. However, target proteins for activated small ubiquitin-like modifiers (SUMOs) downstream molecular consequences behind long-term potentiation (LTP) plasticity remain to be elucidated. In this study, we showed that N-methyl-D-aspartate receptor-mediated neuronal induced...
Although amyloid-β (Aβ) is one of the neuropathological hallmarks Alzheimer's Disease (AD), mechanisms Aβ neurotoxicity remain to be clarified. This study was aimed evaluate effect on postsynaptic density-95 (PSD-95) tyrosine phosphorylation. Elucidating regulatory underlying it may a promising therapy in AD.Aβ25-35 oligomers (20 μg/rat) were administered intracerebroventricularly adult male Sprague-Dawley rats. PSD-95 phosphorylation assessed using immunoprecipitation followed by immunoblot...