A5101691096- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Lipid Membrane Structure and Behavior
- Nicotinic Acetylcholine Receptors Study
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
- Axon Guidance and Neuronal Signaling
- Caveolin-1 and cellular processes
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Wnt/β-catenin signaling in development and cancer
- Chromatin Remodeling and Cancer
- Nuclear Receptors and Signaling
- Cancer, Hypoxia, and Metabolism
- Effects of Radiation Exposure
- Genomics and Chromatin Dynamics
- Herbal Medicine Research Studies
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Menstrual Health and Disorders
- RNA regulation and disease
- Parkinson's Disease Mechanisms and Treatments
- interferon and immune responses
- Pluripotent Stem Cells Research
Soochow University
2025
Xuzhou Medical College
2009-2024
Hong Kong University of Science and Technology
2024
University of Hong Kong
2024
Malignant astrocytoma (MA) is the most common and severe type of brain tumor. A greater understanding underlying mechanisms responsible for development MA would be beneficial targeted molecular therapies. In present study, upregulated differentially expressed genes (DEGs) in were obtained from Gene Expression Omnibus database using R/Bioconductor software. DEGs different World Health Organization classifications compared Venny tool 15 genes, including collagen I α1 chain (COL1A1) laminin...
Objective: This study was designed to explore the toxic effects of Transferrin a(tfa)-mediated uranium exposure on hematopoietic system. Methods: Zebrafish embryos were subjected nitrate solutions at concentrations 50, 100, 250, and 500 μg/L for a defined period, followed by sample collection. The impact system development in zebrafish evaluated through hemoglobin staining, qRT-PCR, situ hybridization. RNA-Seq utilized detect differentially expressed genes (DEGs) exposed 100 uranium, with...
The aim of this study was to identify the receptor for glial cell line-derived neurotrophic factor (GDNF) in glioblastoma multiforme (GBM). After GST pull-down assays, membrane proteins purified from C6 rat glioma cells were subjected liquid chromatography-tandem mass spectrometry (LC-MS/MS). differentially expressed annotated using Gene Ontology, and neuropilin-1 (NRP1) identified as putative GDNF glioma. NRP1 more highly human GBM brains than normal or primary astrocytes....
PSD (postsynaptic density)-95, a scaffold protein that tethers NMDA (N-methyl-D-aspartate) receptors to signal molecules, is implicated in pathological events resulting from excitotoxicity. The present study demonstrates brain ischaemia and reperfusion increase the tyrosine phosphorylation of PSD-95 rat hippocampus. PP2, specific inhibitor SrcPTKs (Src family kinases), prevents ischaemia-induced increases not only PSD-95, but also interaction between Src kinases. phosphorylated either by...
To study the relationship between aging and vulnerability of substantia nigra pars compacta (SNc) tyrosine hydroxylase immunoreactive positive (TH+) dopaminergic (DA) neurons. We determined number TH+ DA neurons in aged rats (24 mon) compared to adult (5 using immunohistochemistry cell counting. Furthermore, expression TH mRNA protein levels SN was studied by semi-quantitative RT-PCR Western blotting. A 13.6% loss detected rostral segment SNc, also reduced (P < 0.05), however, no difference...
Parkinson's disease (PD) is a severe neurodegenerative associated with the loss of dopaminergic (DA) neurons in substantia nigra (SN). Although its pathogenesis remains unclear, microglia-mediated neuroinflammation significantly contributes to development PD. Here we showed that sine oculis homeobox (SIX) homologue family transcription factors SIX2 exerted significant effects on neuroinflammation. The protein, which silenced during development, was reactivated lipopolysaccharide...
Parkinson's disease (PD) is a neurodegenerative characterized by selective loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). We recently reported that Six2 could reverse degeneration DA dephosphorylation state. Here we further identified Eya1 was phosphatase dephosphorylate tyrosine 129 (Y129) site forming complex with damaged cells. Dephosphorylated then translocates from cytoplasm to nucleus. Using ChIP-qPCR and dual luciferase assay, found dephosphorylated...
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor that characterized by its high proliferative and migratory potential, leading to a invasiveness of this type. However, underlying mechanism GBM proliferation migration has not been fully elucidated. In study, at first, we used RNA-seq together with bioinformatics technology screen for C-X-C motif ligand 1 (CXCL1) as proliferation-related gene. And exogenous glial cell line-derived neurotrophic factor (GDNF)...
Glial cell line-derived neurotrophic factor (GDNF), a potential therapeutic for Parkinson's disease (PD), exerts its biological effects through the Ret receptor tyrosine kinase. The redistribution of into lipid rafts substantially influences signaling, but mechanisms underlying translocation remain unclear. purpose our study was to further explore signaling GDNF and determine whether actin cytoskeleton is involved in GDNF-induced rafts. In MN9D dopaminergic neuronal cells, we used density...
Abstract Parkinson's disease (PD) is a neurodegenerative characterized by progressive loss of dopaminergic neurons in the substantia nigra and striatum. Glial cell line‐derived neurotrophic factor (GDNF) can effectively promote differentiation survival many types neurons, especially suggesting it could be treatment for PD. Lipid rafts are highly dynamic membrane domains that contain numerous signal protein receptors, providing an important platform transduction. Compelling evidence indicates...
Abstract Acetylcholinesterase (AChE) has functions in neuroinflammation, beyond its classical role neurotransmission. Understanding the of AChE neuroinflammation is great significance, as it highlights potential therapeutic targets for treatment neurodegenerative diseases. In an vitro study, expression was up‐regulated lipopolysaccharide (LPS)‐induced microglia/macrophage and contrarily potentiated inflammatory responses via disturbing cholinergic anti‐inflammatory pathway (CAP). However,...
Objective: Primary dysmenorrhea (PD) is a prevalent gynecological disorder. Yuanhu Zhitong oral liquid (YHZT) presents promising alternative treatment for PD. However, the mechanisms underlying its efficacy remain unclear. This study aims to investigate potential targets and of action YHZT in treating PD using network pharmacology, molecular docking, dynamics simulations. Methods: Potential compounds from were obtained Traditional Chinese Medicine Systems Pharmacology Database Analysis...