A5065506372- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- PARP inhibition in cancer therapy
- Cancer therapeutics and mechanisms
- CRISPR and Genetic Engineering
- Ovarian cancer diagnosis and treatment
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- Pharmacogenetics and Drug Metabolism
- Biological Stains and Phytochemicals
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Pharmacological Effects of Natural Compounds
- Mycotoxins in Agriculture and Food
- Pharmacological Effects and Toxicity Studies
- RNA and protein synthesis mechanisms
- Nanoparticle-Based Drug Delivery
- DNA Repair Mechanisms
- NF-κB Signaling Pathways
- Nicotinic Acetylcholine Receptors Study
Fujian Medical University
2021-2025
Heinrich Heine University Düsseldorf
2022
Xencor (United States)
2021
Jeonbuk National University
2018-2020
Dongguk University Ilsan Hospital
2020
Henan University of Science and Technology
2020
Chonbuk National University Hospital
2019
National University College
2019
New Generation University College
2019
Nanyang Institute of Technology
2018
Abstract Here, we investigate the potential role of PARP inhibitor rucaparib (CO-338, formerly known as AG014699 and PF-01367338) for treatment sporadic ovarian cancer. We studied growth inhibitory effects in a panel 39 cancer cell lines that were each characterized mutation methylation status BRCA1/2, baseline gene expression signatures, copy number variations selected genes, PTEN status, sensitivity to platinum-based chemotherapy. To study interactions with chemotherapy, used multiple drug...
Multidrug resistance (MDR) is thought to be the major obstacle leading failure of paclitaxel (PTX) chemotherapy. To solve this problem, a glucose transporter-mediated and matrix metalloproteinase 2 (MMP2)-triggered mitochondrion-targeting conjugate [glucose-polyethylene glycol (PEG)–peptide–triphenylphosponium–polyamidoamine (PAMAM)–PTX] composed PAMAM dendrimer enzymatic detachable glucose-PEG was constructed for mitochondrial delivery PTX. The characterized by 30 nm sphere particle,...
Many oncoproteins are considered undruggable because they lack enzymatic activities. In this study, we present a small-molecule-based anticancer agent that acts by inhibiting dimerization of the oncoprotein survivin, thereby promoting its degradation along with spontaneous apoptosis in cancer cells. Through combination computational analysis interface and silico screening, identified one compound induced proteasome-dependent survivin degradation. Analysis set structural analogues led us to...
Beauvericin (BEA), a cyclic depsipeptide, is mycotoxin of the enniatin family and secondary metabolite various toxigenic fungi. Multiple biological functions BEA have been well investigated, such as anti-cancer, anti-inflammatory, anti-microbial, immune-activating functions. In recent study, we showed that can target Toll-like receptor 4 (TLR4) to induce dendritic cell (DC) activation. an in silico screen, identified Cathepsin B (CTSB) potential additional interaction partner for BEA, which...
Background Multidrug resistance (MDR) is a major problem in successful treatment of cancers. Human ABCG2, member the ATP-binding cassette transporter superfamily, plays key role MDR and an important protecting cancer stem cells. Knockout ABCG2 had no apparent adverse effect on mice. Thus, ideal target for development chemo-sensitizing agents better drug resistant cancers helping eradicate Methods/Preliminary Findings Using rational screening representatives from chemical compound library, we...
Human ABCG2, a member of the ATP-binding cassette transporter superfamily, plays key role in multidrug resistance and protecting cancer stem cells. ABCG2-knockout had no apparent adverse effect on development, biochemistry, life mice. Thus, ABCG2 is an interesting promising target for development chemo-sensitizing agents better treatment drug resistant cancers eliminating Previously, we reported novel two mode-acting inhibitor, PZ-39, that induces degradation addition to inhibiting its...
Background: MicroRNAs (miRNAs) play key roles in a variety of pathological processes by interacting with their specific target mRNAs for translation repression and may function as oncogenes (oncomiRs) or tumor suppressors (TSmiRs). Therefore, web server that could predict the regulation relations between miRNAs small molecules is expected to achieve implications identifying potential therapeutic targets anti-tumor drug development. Methods: Upon obtaining positive/known molecule-miRNA pairs...
ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily. Its overexpression causes multidrug resistance in cancer chemotherapy. Based on its apparent half size sequence when compared with other traditional ABC transporters, has been thought to exist and function as homodimer linked by intermolecular disulfide bonds. However, recent evidence suggests that may higher form oligomers due noncovalent interactions. In this study, we attempted create cysless mutant tool for...
PSD (postsynaptic density)-95, a scaffold protein that tethers NMDA (N-methyl-D-aspartate) receptors to signal molecules, is implicated in pathological events resulting from excitotoxicity. The present study demonstrates brain ischaemia and reperfusion increase the tyrosine phosphorylation of PSD-95 rat hippocampus. PP2, specific inhibitor SrcPTKs (Src family kinases), prevents ischaemia-induced increases not only PSD-95, but also interaction between Src kinases. phosphorylated either by...
Abstract Although numerous studies have suggested that canonical IκB kinases (IKK) play a key role in the progression of liver fibrosis, non‐canonical IKKε and TANK‐binding kinase 1 (TBK1) on development fibrosis remains unclear. To demonstrate such issue, repeated injection CCl 4 was used to induce hepatotoxin‐mediated chronic injury biliary induced by 0.1% diethoxycarbonyl‐1, 4‐dihydrocollidine diet feeding for weeks. Mice were orally administered with amlexanox (25, 50, 100 mg/kg) during...
Acetaminophen (APAP) overdose still poses a major clinical challenge and is leading cause of acute liver injury (ALI). N-acetylcysteine (NAC) the only approved antidote to treat APAP toxicity while NAC therapy can trigger side effects including severe vomiting even shock. Thus, new insights in developing novel therapeutic drugs may pave way for better treatment poisoning. Previous research has reported that nuciferine (Nuci) possesses anti-inflammatory antioxidant properties. Therefore,...
Liver fibrosis is a major challenge to global health because of its various complications, including cirrhosis and hepatocarcinoma, while no effective treatment available for it. Sappanone A (SA) homoisoflavonoid extracted from the heartwood Caesalpinia sappan Linn. with anti-inflammatory antioxidant properties. However, effects SA on hepatic remain unknown. This study aimed investigate protective carbon tetrachloride (CCl4)-induced liver in mice. To establish model, mice were treated...