A5083553501- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Bone health and osteoporosis research
- Neuroscience and Neuropharmacology Research
- Computational Drug Discovery Methods
- Chromatography in Natural Products
- Tryptophan and brain disorders
- Liver Disease Diagnosis and Treatment
- Plant-based Medicinal Research
- Microbial Natural Products and Biosynthesis
- Schizophrenia research and treatment
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Microbial Metabolism and Applications
- Metabolomics and Mass Spectrometry Studies
- Bioactive natural compounds
- Sirtuins and Resveratrol in Medicine
- Natural Antidiabetic Agents Studies
- Alzheimer's disease research and treatments
- Healthcare and Venom Research
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Sphingolipid Metabolism and Signaling
- Biomedical Text Mining and Ontologies
- High Altitude and Hypoxia
Guiyang Medical University
2017-2024
Affiliated Hospital of Guizhou Medical University
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Shaanxi Provincial Hospital of Traditional Chinese Medicine
2017-2024
University of Pittsburgh
2024
Beijing HuiLongGuan Hospital
2019-2023
Peking University
2023
Jilin Academy of Traditional Chinese Medicine
2018-2022
Jiangsu University
2017-2022
Zhenjiang City Fourth People's Hospital
2022
ABSTRACT Opportunistic screening for osteoporosis can be performed using low-dose computed tomography (LDCT) imaging obtained other clinical indications. In this study we explored the CT-derived bone mineral density (BMD) and prevalence of from thoracic LDCT in a large population cohort Chinese men women. A total 69,095 adults (40,733 28,362 women) received scan purpose lung cancer between 2018 2019, data were analysis China Biobank Project, prospective nationwide multicenter study. Lumbar...
Existing traditional Chinese medicine (TCM)-related databases are still insufficient in data standardization, integrity and precision, need to be updated urgently. Herein, an Encyclopedia of Traditional Medicine version 2.0 (ETCM v2.0, http://www.tcmip.cn/ETCM2/front/#/) was constructed as the latest curated database hosting 48,442 TCM formulas recorded by ancient medical books, 9872 patent drugs, 2079 medicinal materials 38,298 ingredients. To facilitate mechanistic research new drug...
BackgroundAlthough abdominal adiposity is associated with an altered cardiometabolic risk profile, the specific contribution of adipose tissue distribution remains not fully understood. Computed tomography (CT) a well-established and precise method to measure distribution. The present study investigated assessed by CT in large-scale Chinese population.MethodA total 59,429 adults who underwent low dose chest for lung cancer screening at one 13 health checkup centers throughout China were...
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune that causes demyelination within the central nervous system, typically manifesting as symptoms of optic neuritis and myelitis. We report case 92-year-old patient with NMOSD who was admitted to our hospital; hers currently oldest reported globally. The onset occurred after COVID-19 vaccination, responded well treatment satralizumab.
Cardiocerebral vascular diseases (CCVDs) are the main reasons for high morbidity and mortality all over world, including atherosclerosis, hypertension, myocardial infarction, stroke, so on. Chinese herbs pair of Cinnamomum cassia Presl (Chinese name, rougui) Aconitum carmichaelii Debx fuzi) can be effective in CCVDs, which is recorded ancient classic book Shennong Bencao Jing , Mingyibielu Thousand Golden Prescriptions . However, active ingredients molecular mechanisms rougui‐fuzi treatment...
Pre-diabetes and non-alcoholic fatty liver disease (NAFLD) are associated with an unhealthy lifestyle pose extremely high costs to the healthcare system. In this study, we aim explore whether individualized aerobic exercise (AEx) low carbohydrate diet (LCh) intervention affect hepatic fat content (HFC) in pre-diabetes via modification of gut microbiota composition other post-interventional effects. A 6-month randomized follow-up is conducted from January 2013 December 2015. The target sample...
We aimed to investigate the material basis and mechanisms underlying antitumor activity of Polygonatum sibiricum flower by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MSE). A compound-protein interaction network for cancer was constructed identify potential drug targets, then Kyoto Encyclopedia Genes Genomes (KEGG) pathway analysis conducted elucidate pathways involved in P. flower. Subsequently, molecular docking performed determine...
Abstract Morus alba L has long been used as fodder and a traditional medicine. The different parts of M. (Cortex Mori, Ramulus Folium Mori Fructus Mori) have bioactivities; however, most current evidence is focused on anti‐diabetic properties. In spite their widespread use, few studies compared the chemical composition activity against α ‐glucosidase various medicinal . this study, we developed an HPLC method for simultaneous quality control discrimination Cortex using 13 marker compounds....
Abstract Clinical observations showed that schizophrenia (SCZ) patients reported little or no pain under various conditions are commonly associated with intense painful sensations, leading to a higher risk of morbidity and mortality. However, this phenomenon has received attention its underlying neural mechanisms remain unclear. Here, we conducted two experiments combining psychophysics, electroencephalography (EEG), functional magnetic resonance imaging (fMRI) techniques investigate...
Abstract Clinical symptom‐based diagnosis and therapy play a crucial role in personalized medicine drug discovery. The syndromes, distinctive groups of clinical symptoms summarized by traditional Chinese (TCM) theories experiences, are used as the core diagnostic criteria therapeutic guidance TCM. However, there is still lack standardized data, information, intrinsic molecular basis to help TCM syndromes better classify diseases guide tailored medications. To address this problem, we built...
To study the relationship between aging and vulnerability of substantia nigra pars compacta (SNc) tyrosine hydroxylase immunoreactive positive (TH+) dopaminergic (DA) neurons. We determined number TH+ DA neurons in aged rats (24 mon) compared to adult (5 using immunohistochemistry cell counting. Furthermore, expression TH mRNA protein levels SN was studied by semi-quantitative RT-PCR Western blotting. A 13.6% loss detected rostral segment SNc, also reduced (P < 0.05), however, no difference...