Shenglong Le

ORCID: 0000-0003-0925-9660
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About
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Research Areas
  • Liver Disease Diagnosis and Treatment
  • Diet and metabolism studies
  • Physical Activity and Health
  • Sleep and related disorders
  • Obesity, Physical Activity, Diet
  • Nutrition and Health in Aging
  • Diet, Metabolism, and Disease
  • Cardiovascular and exercise physiology
  • Metabolism, Diabetes, and Cancer
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Diabetes Management and Research
  • Sleep and Wakefulness Research
  • Bone health and osteoporosis research
  • Hip and Femur Fractures
  • Adipose Tissue and Metabolism
  • COVID-19 and Mental Health
  • Psychological Well-being and Life Satisfaction
  • Children's Physical and Motor Development
  • Alcohol Consumption and Health Effects
  • Gut microbiota and health
  • Hypothalamic control of reproductive hormones
  • Pharmacology and Obesity Treatment
  • HIV-related health complications and treatments
  • Body Composition Measurement Techniques
  • Mobile Health and mHealth Applications

Shanghai Jiao Tong University
2013-2024

University of Jyväskylä
2018-2024

Hubei University of Medicine
2022-2024

Taihe Hospital
2022-2024

Background: The coronavirus disease 2019 (COVID-19) pandemic has created challenges that have caused profound changes in health behaviors. This study aimed to explore how COVID-19 is affecting the health-related quality of life (QoL) among Chinese adults. Methods: data behaviors and QoL were collected via online surveys from 2289 adults (mean age = 27.8 ± 12 years) who had been isolated at home for an average 77 days. Results: More than 50% respondents reported their time engaged daily...

10.3390/ijerph17155575 article EN International Journal of Environmental Research and Public Health 2020-08-02

Abstract Exercise and diet are treatments for nonalcoholic fatty liver disease (NAFLD) prediabetes, however, how exercise interventions impact gut microbiota in patients is incompletely understood. We previously reported a 8.6-month, four-arm (Aerobic exercise, n = 29; Diet, 28; Aerobic + No intervention, 29) randomized, singe blinded (for researchers), controlled intervention with NAFLD prediabetes to assess the effect of on primary outcomes fat content glucose metabolism. Here we report...

10.1038/s41467-022-29968-0 article EN cc-by Nature Communications 2022-05-10

The study aimed to assess whether aerobic exercise (AEx) training and a fibre-enriched diet can reduce hepatic fat content (HFC) increase glycaemic control in pre-diabetic patients with non-alcoholic fatty liver disease (NAFLD). Six-hundred-and-three from seven clinics Yangpu district, Shanghai, China were recruited. Of them 115 individuals aged 50-65-year fulfilled the inclusion criteria (NAFLD impaired fasting glucose or tolerance) randomly assigned into (AEx n = 29), (Diet 28), plus (AED...

10.1038/s41598-017-16159-x article EN cc-by Scientific Reports 2017-11-15

Background Objective assessments of sedentary behavior and physical activity (PA) by using accelerometer-based wearable devices are ever expanding, given their importance in the global context health maintenance. This study aimed to determine reliability validity a new analyzer (Fibion) for detecting different PAs estimating energy expenditure (EE) during simulated free-living day. Methods The consisted two parts: ( n = 18) 19) test. Reliability was assessed 45 min protocol repeated sitting,...

10.7717/peerj.5775 article EN cc-by PeerJ 2018-10-11

Objective To explore how a stringent campus lockdown affects the physical activity (PA), sleep and mental health of Chinese university students living in student dormitories during COVID-19 pandemic. Methods Data on PA, were collected between 24 March 4 April 2022 from 2084 (mean age = 22.4 years, 61.1% male students) via an online questionnaire distributed by students’ advisers each dormitory. The short version International Physical Activity Questionnaire (IPAQ-C), Athens Insomnia Scale...

10.3389/fpsyg.2022.1022966 article EN cc-by Frontiers in Psychology 2022-10-17

ABSTRACT Background This study aimed to assess the response patterns of circulating lipids exercise and diet interventions in nonalcoholic fatty liver disease (NAFLD). Methods The 8.6-month four-arm randomized controlled comprised 115 NAFLD patients with prediabetes who were assigned aerobic (AEx; n = 29), low-carbohydrate (Diet; 28), AEx plus (AED; nonintervention (NI, 29) groups. Hepatic fat content (HFC) was quantified by proton magnetic resonance spectroscopy. Serum lipidomic analytes...

10.1249/mss.0000000000003388 article EN cc-by-nc-nd Medicine & Science in Sports & Exercise 2024-01-17

This study investigated the factors that are associated with sleep disturbances among Chinese athletes. Sleep quality and were assessed by Athlete Screening Questionnaire (ASSQ, n ​= ​394, aged 18-32 years, 47.6% female). difficulty score (SDS) level of problem (none, mild, moderate, or severe) used to classify participants' quality. Categorical variables analyzed Chi-square fisher's exact tests. An ordinal logistic regression analysis was explore poor (SDS ≥8). Approximately 14.2%...

10.1016/j.smhs.2022.02.001 article EN cc-by-nc-nd Sports Medicine and Health Science 2022-02-10

Objective . The purpose of the study was to examine acute effects timing exercise on glycemic control during and after in T2D. Methods This included 26 T2D patients (14 women 12 men) who were treated with metformin. All tested four occasions: metformin administration alone (Metf), high-intensity interval training (HIIT) performed at 30 minutes (EX30), 60 (EX60), 90 (EX90) postbreakfast, respectively. Glucose, insulin, superoxide dismutase (SOD) activity examined. Results Glucose decreased...

10.1155/2018/2483273 article EN cc-by Journal of Diabetes Research 2018-01-01

This study aimed to assess whether the benefits of exercise on central adiposity and insulin resistance (HOMA-IR) are maintained after discontinuation intervention in overweight/obese (OWOB) women.The subjects were from 2 independent studies with similar aerobic (AE) programs. In I, 15 OWOB postmenopausal women pre-diabetes (body mass index, BMI = 24-33 kg/m2, aged 52-65 years) completed an 8-month followed for years intervention. II, 12 (BMI 25-35 30-50 premenopausal participated a 6-week...

10.1016/j.jshs.2016.04.003 article EN cc-by-nc-nd Journal of sport and health science/Journal of Sport and Health Science 2016-04-10

Commercially wrist-worn devices often present inaccurate estimations of energy expenditure (EE), with large between-device differences. We aimed to assess the validity Apple Watch Series 6 (AW), Garmin FENIX (GF) and Huawei GT 2e (HW) in estimating EE during outdoor walking running. Twenty young normal-weight Chinese adults concurrently wore three index randomly positioned at both wrists km/h running 10 for 2 km on a 400- meter track. As criterion, was assessed by indirect calorimetry...

10.3389/fphys.2022.995575 article EN cc-by Frontiers in Physiology 2022-09-26

Objective This study aimed to investigate directional influences in the association between adiposity and physical activity (PA) from pre-puberty early adulthood. Methods In Calex-study, height, weight, body fat leisure-time (LTPA) were measured at age11.2-years, 13.2-years 18.3-years 396 Finnish girls. Body was by dual-energy X-ray absorptiometry, calculating mass index (FMI) as total kilograms divided height meters squared. LTPA level evaluated using a questionnaire. European Youth Heart...

10.3389/fendo.2023.1135852 article EN cc-by Frontiers in Endocrinology 2023-06-19

Accumulating evidence show that exercise and diet interventions are associated with improved sleep quality. Studies investigating the effects of dieting on circulating metabolomics in people disorders, particularly insomnia, scarce. This 6-month randomized study aimed to assess dietary serum metabolites men insomnia symptoms. Seventy-two Finnish (age: 51.6 ± 10.1 years) chronic symptoms who were assigned different intervention groups completed this (exercise, n = 24; diet, 27; control, 21)....

10.1016/j.smhs.2020.05.002 article EN cc-by-nc-nd Sports Medicine and Health Science 2020-05-22

Nonalcoholic fatty liver disease (NAFLD) is a disorder that extends from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), which effectively alleviated by lifestyle intervention. Nevertheless, DNA methylation mechanism underling the effect of environmental factors on NAFLD and NASH still obscure. The aim this study was investigate exercise diet intervention in via GAB2.Methylation genomic human quantified using Infinium Methylation EPIC BeadChip assay after (Ex), low...

10.1186/s13578-021-00701-6 article EN cc-by Cell & Bioscience 2021-11-04

Background The directional influences between serum sex hormone-binding globulin (SHBG), adiposity and insulin resistance during pubertal growth remain unclear. aim of this study was to investigate bidirectional associations SHBG (HOMA-IR) from childhood early adulthood. Methods Participants were 396 healthy girls measured at baseline (age 11.2 years) 1, 2, 4 7.5 years. Serum concentrations estradiol, testosterone determined by ELISA, glucose enzymatic photometry, insulin-like factor 1...

10.1530/ec-19-0044 article EN cc-by-nc-nd Endocrine Connections 2019-03-29

Obesity and ethnicity play important roles in cardiovascular complications patients with type 2 diabetes mellitus (T2DM). This study aimed to compare cardiometabolic risk profiles between Chinese Finnish older adults of central obesity prediabetes or T2DM. Study subjects were 60-74 years old originated from two population samples. The came the Kuopio Ischemic Heart Disease (KIHD) (n = 1089), Shanghai High-risk Diabetic Screen (SHiDS) 818). KIHD SHiDS studies used similar questionnaires...

10.1007/s40618-022-01777-8 article EN cc-by Journal of Endocrinological Investigation 2022-03-24

This study investigated the impact of Nordic walking on bone properties in postmenopausal women with pre-diabetes and non-alcohol fatty liver disease (NAFLD). A total 63 eligible randomly participated training (AEx, n = 33), or maintained their daily lifestyle (Con, 30) during intervention. Bone mineral content (BMC) density (BMD) whole body (WB), femur (TF), femoral neck (FN), lumbar spine (L2-4) were assessed by dual-energy X-ray absorptiometry. Serum osteocalcin, pentosidine, receptor...

10.3390/ijerph18147570 article EN International Journal of Environmental Research and Public Health 2021-07-16

This study assessed the associations of maximal isometric strength and movement economy in 126 recreationally active men women. Oxygen consumption was through a graded treadmill test with 4-minute increments (4-12 km∙h-1). Maximal leg extensor, flexor handgrip were by dynamometry. Models best fit for gross oxygen cost caloric unit observed across majority velocities when extensor/flexor ratio combined (R2 = 0.207-0.525 R2 0.152-0.475, respectively). Additionally, differed statistically...

10.1080/15438627.2021.1917404 article EN Research in Sports Medicine 2021-04-18

Purpose: This study aimed to characterize sleep quality and explore the factors that are associated with severity of difficulty among Chinese collegiate athletes. Methods: Sleep were assessed by Athlete Screening Questionnaire (ASSQ) in college athletes (n = 395, 73.6% response rate, aged 18 32 years, 47.6% female, 22.5% master level, national level 29.9% second 15 different sports events). A score (SDS) problem (0-4, none; 5-7, mild; 8-10, moderate; 11-17, severe) used classify...

10.1249/01.mss.0000880528.53759.34 article EN Medicine & Science in Sports & Exercise 2022-09-01

Abstract Background: How bone properties would change after exercise intervention in patients with comorbidities are largely unknown. This study investigated the impact of Nordic walking on postmenopausal women pre-diabetes and non-alcohol fatty liver disease (NAFLD). Methods: The is a part large randomized controlled trial. Of eligible participants, 63 (aged 50-65 years) prediabetes NAFLD participated either progressive supervised training (60-75% VO2max intensity), 2-3 times/week, 30-60...

10.21203/rs.3.rs-284882/v1 preprint EN cc-by Research Square (Research Square) 2021-03-18

Concurrent exercise and metformin administration may reduce the acute chronic effects of on glucose metabolism in patients with type 2 diabetes (T2D). However, several studies suggest that combing treatment have neither additive effect nor even cause adverse T2D patients. This case report aimed to highlight challenges associated prescribing undergoing treatment. A 67-years old woman was followed-up for five months, including assessment lactate induced by concomitant metformin. The findings...

10.1016/j.smhs.2023.02.003 article EN cc-by-nc-nd Sports Medicine and Health Science 2023-02-20
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