A5100339265- Pharmacological Effects of Natural Compounds
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Traditional Chinese Medicine Analysis
- Immune cells in cancer
- Plant-based Medicinal Research
- TGF-β signaling in diseases
- Fibroblast Growth Factor Research
- Medicinal Plant Pharmacodynamics Research
- Advanced Drug Delivery Systems
- Drug-Induced Hepatotoxicity and Protection
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Natural product bioactivities and synthesis
- Pharmacy and Medical Practices
- Computational Drug Discovery Methods
- Phytochemical compounds biological activities
- Chromatography in Natural Products
- Liver physiology and pathology
- Ginseng Biological Effects and Applications
- Contact Dermatitis and Allergies
- Botanical Studies and Applications
- Healthcare and Venom Research
- Glutathione Transferases and Polymorphisms
- Renal Transplantation Outcomes and Treatments
Shaanxi Provincial Hospital of Traditional Chinese Medicine
2024
Jilin Jianzhu University
2023
Jilin Academy of Traditional Chinese Medicine
2013-2022
Sun Yat-sen University
2017-2021
Fudan University
2017
First People's Hospital of Foshan
2017
Hebei University of Science and Technology
2017
Shaanxi University of Chinese Medicine
2017
Wenzhou Medical University
2016
Beijing Geriatric Hospital
2016
HepaRG cells, derived from a female hepatocarcinoma patient, are capable of differentiating into biliary epithelial cells and hepatocytes. More importantly, differentiated able to maintain activities many xenobiotic-metabolizing enzymes, expression the metabolizing enzyme genes can be induced by xenobiotics. The ability these express induce enzymes is in stark contrast frequently used HepG2 cells. previous studies have mainly focused on set selected genes; therefore, it significant interest...
// Rui Su 1,2,3 , Wufa Fan 2 Qin Yu 4 Xiaochun Dong Jianping Qi 3,4 Quangang Zhu Weili Zhao 2,4 Wei Wu Zhongjian Chen Ye Li 3 and Yi Lu 1 Shaanxi University of Chinese Medicine, Xianyang, P.R. China School Pharmacy, Fudan University, Key Laboratory Smart Drug Delivery MOE PLA, Shanghai, P.R.China Academy Traditional Xi’an, Shanghai Dermatology Hospital, Correspondence to: Chen, email: Li, Lu, Keywords : nanoemulsions, transdermal delivery, immunization, aggregation-caused quenching...
Objectives Cytochrome P450 oxidoreductase (POR) is the only flavoprotein that donates electrons to all microsomal enzymes, which catalyze biosynthesis of steroids, fatty acids, and bile as well metabolism more than 80% prescription drugs. Although mutations in POR have been identified several disease states with disordered steroidogenesis, effects polymorphisms on drug general population are unclear. In this report, we performed a comprehensive study correlate gene expression, activity,...
Nasal drug delivery is a fascinating approach to bypass the blood-brain barrier, which instead directly transports molecules brain from nasal cavity along olfactory and trigeminal nerves. However, feasibility of nose-to-brain transportation intact nanoparticles possible corresponding pathways remain poorly understood. The purpose present study explore intranasal fate curcumin (Cur)-loaded polycaprolactone (PCL NPs) via fluorescent bioimaging strategies. behavior was tracked by...
Cardiocerebral vascular diseases (CCVDs) are the main reasons for high morbidity and mortality all over world, including atherosclerosis, hypertension, myocardial infarction, stroke, so on. Chinese herbs pair of Cinnamomum cassia Presl (Chinese name, rougui) Aconitum carmichaelii Debx fuzi) can be effective in CCVDs, which is recorded ancient classic book Shennong Bencao Jing , Mingyibielu Thousand Golden Prescriptions . However, active ingredients molecular mechanisms rougui‐fuzi treatment...
Abstract Morus alba L has long been used as fodder and a traditional medicine. The different parts of M. (Cortex Mori, Ramulus Folium Mori Fructus Mori) have bioactivities; however, most current evidence is focused on anti‐diabetic properties. In spite their widespread use, few studies compared the chemical composition activity against α ‐glucosidase various medicinal . this study, we developed an HPLC method for simultaneous quality control discrimination Cortex using 13 marker compounds....
CYP2D6 is an important cytochrome P450 (P450) enzyme that metabolizes approximately 25% of therapeutic drugs. Its genetic polymorphisms may significantly influence the pharmacokinetics and pharmacodynamics clinically used Studying effects on drug metabolism can help reduce adverse reactions failure to some extent. This study aimed investigate role in nebivolol by evaluating effect 24 variants vitro. expressed insect cell systems were incubated with 0.1-80 μM for 30 minutes at 37°C reaction...
Erycibe obtusifolia and E. schmidtii are widely used in traditional Chinese medicine (TCM) to treat joint pain rheumatoid arthritis. With the reduction of wild resources, Porana sinensis has been as a substitute. However, few studies have conducted on chemical composition quality control P. sinensis.To clarify improve sinensis.We developed an ultra-high performance liquid chromatography electrospray ionisation Q-Exactive Focus tandem mass spectrometry (UHPLC-ESI-Q-Exactive Focus-MS/MS)...
Western drugs have achieved great successes in CVDs treatment. However, they may lead to some side effects and drug resistance. On the other hand, more studies found that Traditional Chinese herbs efficient therapeutic for CVDs, while their mechanism is still not very clear. It be a good view towards molecules, targets network decipher whether difference exists between anti-CVD western herbal ingredients. Anti-CVD ingredients, as well were thoroughly collected this work. The similarities...
A novel polysaccharide (PSPW-3-a) with a molecular weight of 1.29 × 104 Da was extracted and isolated from wine-processed Polygonatum sibiricum (PS) using fractional ethanol precipitation column chromatography. Structural analysis illustrated that the backbone PSPW-3-a composed →4)-β-D-Galp-(1→, terminal branch present as β-D-Galp connected to O-6 glycosidic bond main chain. Additionally, promoted secretion IL-1β, TNF-α, IFN-γ cytokines induced activity T-SOD, GSH, CAT oxidases in RAW264.7...
The NF-κB signalling pathway has been reported to be related liver fibrosis, and we investigated whether the is involved in fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis (CssPLA2). Furthermore, expression receptor CssPLA2 on cell surface hepatic stellate cells (HSCs) may greatly contribute fibrosis.CssPLA2 was administered BALB/c mice abdominal injection. levels markers activation mouse tissue were measured quantitative RT-PCR, ELISA western blot. Additionally, HSCs...