A5000617780- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Nanoplatforms for cancer theranostics
- Lipid Membrane Structure and Behavior
- Protein Interaction Studies and Fluorescence Analysis
- Drug Solubulity and Delivery Systems
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Transgenic Plants and Applications
- Immunotherapy and Immune Responses
- Berberine and alkaloids research
- Contact Dermatitis and Allergies
- Anesthesia and Pain Management
- Lymphatic System and Diseases
- Surfactants and Colloidal Systems
- Gold and Silver Nanoparticles Synthesis and Applications
- Ocular Surface and Contact Lens
- Nanopore and Nanochannel Transport Studies
- Corneal Surgery and Treatments
- Inhalation and Respiratory Drug Delivery
- Toxin Mechanisms and Immunotoxins
- Dermatology and Skin Diseases
- Silymarin and Mushroom Poisoning
Zhejiang University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking University
2020-2023
Zhejiang University of Science and Technology
2022
Fudan University
2015-2021
Beijing National Laboratory for Molecular Sciences
2020
SAIC-GM (China)
2015
Orally administrable anticancer nanomedicines are highly desirable due to their easy and repeatable administration, but not yet feasible because the current nanomedicine cannot simultaneously overcome strong mucus villi barriers thus have very low bioavailability (BA). Herein, this work presents first polymeric micelle capable of fast permeation absorption delivering paclitaxel (PTX) efficiently tumors with therapeutic efficacy even better than intravenously administered polyethylene glycol...
The nose-to-brain pathway has been proven to be a shortcut for direct drug delivery the brain. However, whether and what extent nanoparticles can delivered through this passage is still awaiting validation with evidence. In study, transportation of tracked via fluorescence bioimaging strategies using nanoemulsions (NEs) as model carriers. Identification NEs in biological tissues based on → off signal switching new type environment-responsive embedded dyes, P2 P4, two conventional probes, DiR...
// Rui Su 1,2,3 , Wufa Fan 2 Qin Yu 4 Xiaochun Dong Jianping Qi 3,4 Quangang Zhu Weili Zhao 2,4 Wei Wu Zhongjian Chen Ye Li 3 and Yi Lu 1 Shaanxi University of Chinese Medicine, Xianyang, P.R. China School Pharmacy, Fudan University, Key Laboratory Smart Drug Delivery MOE PLA, Shanghai, P.R.China Academy Traditional Xi’an, Shanghai Dermatology Hospital, Correspondence to: Chen, email: Li, Lu, Keywords : nanoemulsions, transdermal delivery, immunization, aggregation-caused quenching...
Evidence by ACQ probes marking integral SLNs doesn't support absorption of intact vehicles, which are mainly located in intestinal mucus layers.
The in vivo translocation of nanoemulsions (NEs) was tracked by imaging tools with an emphasis on the size effect. To guarantee accurate identification NEs vivo, water-quenching environment-responsive near-infrared fluorescent probes were used to label NEs. Imaging evidence confirmed prominent digestion gastrointestinal tract and oral absorption integral that survive enteric epithelia a size-dependent way. In general, reducing particle leads slowed vitro lipolysis digestion, prolonged...
Transcytosis-based active transport of cancer nanomedicine has shown great promise for enhancing its tumor extravasation and infiltration antitumor activity, but how the key nanoproperties nanomedicine, particularly particle size, influence transcytosis remains unknown. Herein, we used a transcytosis-inducing polymer, poly[2-(N-oxide-N,N-diethylamino)ethyl methacrylate] (OPDEA), fabricated stable OPDEA-based micelles with different sizes (30, 70, 140 nm in diameter) from amphiphilic block...
The long-circulating effect is revisited by simultaneous monitoring of the drug payloads and nanocarriers following intravenous administration doxorubicin (DOX)-loaded methoxy polyethylene glycol-polycaprolactone (mPEG-PCL) nanoparticles. Comparison kinetic profiles both DOX verifies effect, though limited degree, as a result pegylation. nanocarrier display fast clearance from blood despite dense PEG decoration; cleared faster than nanocarriers. circulate longer in blood, suggesting possible...
Surface charge is a crucial factor that determines the in vivo behaviors of drug nanocarriers following administration via different routes. However, there still lack comprehensive knowledge how surface charges affect particles, especially for oral delivery. In this study, solid lipid nanoparticles (SLNs), as model nanocarriers, are modified to bear either anionic, cationic, or net neutral charges. The effect on absorption intact SLNs was investigated by tracking transport particles....
The transformation of lipid-based nanovehicles into mixed micelles (MMs) upon lipolysis plays an indispensable role in enhancement the oral bioavailability poorly water-soluble drugs. Therefore, this study employs biomimetic MMs as functional vehicles to enhance lipid conjugates a model drug silybin. main objective is explore vivo fate and underlying mechanisms facilitated absorption by MMs. Pharmacokinetics rats indicate 7–9 folds compared fast-release silybin solid dispersion formulation....
Incorporation of orlistat, a lipase inhibitor, into the matrix solid lipid nanoparticles slows down lipolysis significantly and thereby enhances gastrointestinal survival rate oral absorption intact particles.